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Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials.

Mega, Jessica L ; Stitziel, Nathan O ; Smith, Gustav LU ; Chasman, Daniel I ; Caulfield, Mark J ; Devlin, James J ; Nordio, Francesco ; Hyde, Craig L ; Cannon, Christopher P and Sacks, Frank M , et al. (2015) In The Lancet 385(9984). p.2264-2271
Abstract
Genetic variants have been associated with the risk of coronary heart disease. In this study, we tested whether or not a composite of these variants could ascertain the risk of both incident and recurrent coronary heart disease events and identify those individuals who derive greater clinical benefit from statin therapy.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Lancet
volume
385
issue
9984
pages
2264 - 2271
publisher
Elsevier
external identifiers
  • pmid:25748612
  • wos:000355943500028
  • scopus:84934277268
ISSN
1474-547X
DOI
10.1016/S0140-6736(14)61730-X
language
English
LU publication?
yes
id
bd85bff6-00de-42f4-9fcf-a2c816cebc92 (old id 5265071)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25748612?dopt=Abstract
date added to LUP
2016-04-01 10:44:13
date last changed
2024-01-06 23:15:13
@article{bd85bff6-00de-42f4-9fcf-a2c816cebc92,
  abstract     = {{Genetic variants have been associated with the risk of coronary heart disease. In this study, we tested whether or not a composite of these variants could ascertain the risk of both incident and recurrent coronary heart disease events and identify those individuals who derive greater clinical benefit from statin therapy.}},
  author       = {{Mega, Jessica L and Stitziel, Nathan O and Smith, Gustav and Chasman, Daniel I and Caulfield, Mark J and Devlin, James J and Nordio, Francesco and Hyde, Craig L and Cannon, Christopher P and Sacks, Frank M and Poulter, Neil R and Sever, Peter S and Ridker, Paul M and Braunwald, Eugene and Melander, Olle and Kathiresan, Sekar and Sabatine, Marc S}},
  issn         = {{1474-547X}},
  language     = {{eng}},
  number       = {{9984}},
  pages        = {{2264--2271}},
  publisher    = {{Elsevier}},
  series       = {{The Lancet}},
  title        = {{Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials.}},
  url          = {{http://dx.doi.org/10.1016/S0140-6736(14)61730-X}},
  doi          = {{10.1016/S0140-6736(14)61730-X}},
  volume       = {{385}},
  year         = {{2015}},
}