Central sensitization and severity of gastrointestinal symptoms in irritable bowel syndrome, chronic pain syndromes, and inflammatory bowel disease
(2021) In Neurogastroenterology and Motility 33(12).- Abstract
BACKGROUND: Central sensitization has been suggested as an explanation of the wide range of gastrointestinal and extraintestinal symptoms commonly seen in irritable bowel syndrome (IBS). In this study, the presence and level of central sensitization, and its association to gastrointestinal (GI) symptoms were explored in IBS in comparison with control groups.
METHODS: We investigated patients with IBS (n = 215), chronic pain disorders (n = 36), and inflammatory bowel disease (IBD) (n = 40) and volunteers without chronic diseases (n = 112). The Central Sensitization Inventory (CSI) was translated and validated in Swedish and used together with the Highly Sensitive Person (HSP) scale to measure the presence and level of central... (More)
BACKGROUND: Central sensitization has been suggested as an explanation of the wide range of gastrointestinal and extraintestinal symptoms commonly seen in irritable bowel syndrome (IBS). In this study, the presence and level of central sensitization, and its association to gastrointestinal (GI) symptoms were explored in IBS in comparison with control groups.
METHODS: We investigated patients with IBS (n = 215), chronic pain disorders (n = 36), and inflammatory bowel disease (IBD) (n = 40) and volunteers without chronic diseases (n = 112). The Central Sensitization Inventory (CSI) was translated and validated in Swedish and used together with the Highly Sensitive Person (HSP) scale to measure the presence and level of central sensitization. Furthermore, severity of GI symptoms (GSRS-IBS and IBS-SSS), and anxiety and depression (HAD) were determined.
KEY RESULTS: The Swedish translation of CSI demonstrated excellent validity. Central sensitization, defined by validated cut-off levels for CSI and HSP, was common in the whole cohort (40% and 28%) and in IBS (57% and 35%). Study participants with central sensitization had more severe GI symptoms, anxiety and depression, than participants without central sensitization. Strong associations were seen between CSI and GI symptom severity in the whole cohort (GSRS-IBS: partial η2 = 0.455, p < 0.001; IBS-SSS: partial η2 = 0.408, p < 0.001), with decreasing strength in patients with chronic pain, IBD, IBS, and volunteers.
CONCLUSION AND INFERENCES: Central sensitization was common in IBS and associated with GI symptom severity, but with stronger associations in chronic pain disorders and IBD. This implies that other mechanisms may be of equal or greater importance for GI symptom severity in IBS.
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- author
- Midenfjord, Irina ; Grinsvall, Cecilia ; Koj, Peter ; Carnerup, Ida LU ; Törnblom, Hans and Simrén, Magnus
- publishing date
- 2021-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Anxiety/diagnosis, Central Nervous System Sensitization/physiology, Chronic Pain/diagnosis, Depression/diagnosis, Female, Humans, Inflammatory Bowel Diseases/diagnosis, Irritable Bowel Syndrome/diagnosis, Male, Middle Aged, Pain Measurement, Severity of Illness Index, Surveys and Questionnaires, Symptom Assessment, Young Adult
- in
- Neurogastroenterology and Motility
- volume
- 33
- issue
- 12
- article number
- e14156
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85104351011
- pmid:33860970
- ISSN
- 1350-1925
- DOI
- 10.1111/nmo.14156
- language
- English
- LU publication?
- no
- additional info
- © 2021 John Wiley & Sons Ltd.
- id
- bd9e1758-595a-4127-9345-d2f1c874cd5d
- date added to LUP
- 2024-11-14 09:52:32
- date last changed
- 2025-05-02 17:28:15
@article{bd9e1758-595a-4127-9345-d2f1c874cd5d,
abstract = {{<p>BACKGROUND: Central sensitization has been suggested as an explanation of the wide range of gastrointestinal and extraintestinal symptoms commonly seen in irritable bowel syndrome (IBS). In this study, the presence and level of central sensitization, and its association to gastrointestinal (GI) symptoms were explored in IBS in comparison with control groups.</p><p>METHODS: We investigated patients with IBS (n = 215), chronic pain disorders (n = 36), and inflammatory bowel disease (IBD) (n = 40) and volunteers without chronic diseases (n = 112). The Central Sensitization Inventory (CSI) was translated and validated in Swedish and used together with the Highly Sensitive Person (HSP) scale to measure the presence and level of central sensitization. Furthermore, severity of GI symptoms (GSRS-IBS and IBS-SSS), and anxiety and depression (HAD) were determined.</p><p>KEY RESULTS: The Swedish translation of CSI demonstrated excellent validity. Central sensitization, defined by validated cut-off levels for CSI and HSP, was common in the whole cohort (40% and 28%) and in IBS (57% and 35%). Study participants with central sensitization had more severe GI symptoms, anxiety and depression, than participants without central sensitization. Strong associations were seen between CSI and GI symptom severity in the whole cohort (GSRS-IBS: partial η2 = 0.455, p < 0.001; IBS-SSS: partial η2 = 0.408, p < 0.001), with decreasing strength in patients with chronic pain, IBD, IBS, and volunteers.</p><p>CONCLUSION AND INFERENCES: Central sensitization was common in IBS and associated with GI symptom severity, but with stronger associations in chronic pain disorders and IBD. This implies that other mechanisms may be of equal or greater importance for GI symptom severity in IBS.</p>}},
author = {{Midenfjord, Irina and Grinsvall, Cecilia and Koj, Peter and Carnerup, Ida and Törnblom, Hans and Simrén, Magnus}},
issn = {{1350-1925}},
keywords = {{Adult; Anxiety/diagnosis; Central Nervous System Sensitization/physiology; Chronic Pain/diagnosis; Depression/diagnosis; Female; Humans; Inflammatory Bowel Diseases/diagnosis; Irritable Bowel Syndrome/diagnosis; Male; Middle Aged; Pain Measurement; Severity of Illness Index; Surveys and Questionnaires; Symptom Assessment; Young Adult}},
language = {{eng}},
number = {{12}},
publisher = {{Wiley-Blackwell}},
series = {{Neurogastroenterology and Motility}},
title = {{Central sensitization and severity of gastrointestinal symptoms in irritable bowel syndrome, chronic pain syndromes, and inflammatory bowel disease}},
url = {{http://dx.doi.org/10.1111/nmo.14156}},
doi = {{10.1111/nmo.14156}},
volume = {{33}},
year = {{2021}},
}