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Mitotic Count and Estimation of the Risk of GIST Recurrence in Patients Treated with Preoperative Imatinib

Eriksson, Mikael LU orcid and Joensuu, Heikki (2019) In Clinical Oncology and Research 2(5). p.1-2
Abstract
Preoperative imatinib is used frequently in the treatment of large localized GISTs to shrink the tumor prior to surgery. This approach may lead to challenges in the estimation of the risk of recurrence and the need of adjuvant imatinib, because the diagnosis is usually made from a needle biopsy with scant tissue for the assessment of GIST mitotic activity, a key prognostic factor. We propose a mitosis count multiplication method as a proxy for estimating the tumor mitotic count in select cases.
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Oncology and Research
volume
2
issue
5
pages
1 - 2
publisher
Science Repository
ISSN
2613-4942
language
English
LU publication?
yes
id
bdcb3460-4b29-45d0-8326-55daaecd770c
alternative location
https://www.sciencerepository.org/mitotic-count-and-estimation-of-the-risk-of-gist-recurrence_COR-2019-5-115
date added to LUP
2020-03-02 16:01:28
date last changed
2020-03-02 16:01:28
@misc{bdcb3460-4b29-45d0-8326-55daaecd770c,
  abstract     = {{Preoperative imatinib is used frequently in the treatment of large localized GISTs to shrink the tumor prior to surgery. This approach may lead to challenges in the estimation of the risk of recurrence and the need of adjuvant imatinib, because the diagnosis is usually made from a needle biopsy with scant tissue for the assessment of GIST mitotic activity, a key prognostic factor. We propose a mitosis count multiplication method as a proxy for estimating the tumor mitotic count in select cases.}},
  author       = {{Eriksson, Mikael and Joensuu, Heikki}},
  issn         = {{2613-4942}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{1--2}},
  publisher    = {{Science Repository}},
  series       = {{Clinical Oncology and Research}},
  title        = {{Mitotic Count and Estimation of the Risk of GIST Recurrence in Patients Treated with Preoperative Imatinib}},
  url          = {{https://www.sciencerepository.org/mitotic-count-and-estimation-of-the-risk-of-gist-recurrence_COR-2019-5-115}},
  volume       = {{2}},
  year         = {{2019}},
}