Effect Modification between Genes and Environment and Parkinson's Disease Risk
(2022) In Annals of Neurology 92(5). p.715-724- Abstract
Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and environmental factors interact to contribute to its etiology. Remarkable progress has been made in deciphering disease etiology through genetic approaches, but there is limited data about how environmental and genetic factors interact to modify penetrance, risk, and disease severity. Here, we provide insights into environmental modifiers of PD, discussing precedents from other neurological and non-neurological conditions. Based on these examples, we outline genetic and environmental factors contributing to PD and review potential environmental modifiers of penetrance and clinical variability in monogenic and idiopathic PD. We also highlight the... (More)
Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and environmental factors interact to contribute to its etiology. Remarkable progress has been made in deciphering disease etiology through genetic approaches, but there is limited data about how environmental and genetic factors interact to modify penetrance, risk, and disease severity. Here, we provide insights into environmental modifiers of PD, discussing precedents from other neurological and non-neurological conditions. Based on these examples, we outline genetic and environmental factors contributing to PD and review potential environmental modifiers of penetrance and clinical variability in monogenic and idiopathic PD. We also highlight the potential challenges and propose how future studies might tackle these important questions. ANN NEUROL 2022.
(Less)
- author
- organization
- publishing date
- 2022-11
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of Neurology
- volume
- 92
- issue
- 5
- pages
- 10 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:35913124
- scopus:85138693948
- ISSN
- 0364-5134
- DOI
- 10.1002/ana.26467
- language
- English
- LU publication?
- yes
- additional info
- Funding Information: This work was supported in part by the Global Parkinson's Genetics Program (GP2). GP2 is funded by the Aligning Science Against Parkinson's (ASAP) initiative and implemented by The Michael J. Fox Foundation for Parkinson's Research ( https://gp2.org ). For a complete list of GP2 members see https://gp2.org . This research was supported in part by the Intramural Research Program of the National Institutes of Health (National Institute on Aging, Z01‐AG000949‐02). The Preventive Neurology Unit is funded by the Barts Charity. Publisher Copyright: © 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
- id
- bdee5884-351b-44e1-86c3-15b1ef6d4507
- date added to LUP
- 2022-10-10 16:26:58
- date last changed
- 2024-09-20 21:20:45
@article{bdee5884-351b-44e1-86c3-15b1ef6d4507, abstract = {{<p>Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and environmental factors interact to contribute to its etiology. Remarkable progress has been made in deciphering disease etiology through genetic approaches, but there is limited data about how environmental and genetic factors interact to modify penetrance, risk, and disease severity. Here, we provide insights into environmental modifiers of PD, discussing precedents from other neurological and non-neurological conditions. Based on these examples, we outline genetic and environmental factors contributing to PD and review potential environmental modifiers of penetrance and clinical variability in monogenic and idiopathic PD. We also highlight the potential challenges and propose how future studies might tackle these important questions. ANN NEUROL 2022.</p>}}, author = {{Periñán, Maria Teresa and Brolin, Kajsa and Bandres-Ciga, Sara and Blauwendraat, Cornelis and Klein, Christine and Gan-Or, Ziv and Singleton, Andrew and Gomez-Garre, Pilar and Swanberg, Maria and Mir, Pablo and Noyce, Alastair}}, issn = {{0364-5134}}, language = {{eng}}, number = {{5}}, pages = {{715--724}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Annals of Neurology}}, title = {{Effect Modification between Genes and Environment and Parkinson's Disease Risk}}, url = {{http://dx.doi.org/10.1002/ana.26467}}, doi = {{10.1002/ana.26467}}, volume = {{92}}, year = {{2022}}, }