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Effect Modification between Genes and Environment and Parkinson's Disease Risk

Periñán, Maria Teresa ; Brolin, Kajsa LU orcid ; Bandres-Ciga, Sara ; Blauwendraat, Cornelis ; Klein, Christine ; Gan-Or, Ziv ; Singleton, Andrew ; Gomez-Garre, Pilar ; Swanberg, Maria LU and Mir, Pablo , et al. (2022) In Annals of Neurology 92(5). p.715-724
Abstract

Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and environmental factors interact to contribute to its etiology. Remarkable progress has been made in deciphering disease etiology through genetic approaches, but there is limited data about how environmental and genetic factors interact to modify penetrance, risk, and disease severity. Here, we provide insights into environmental modifiers of PD, discussing precedents from other neurological and non-neurological conditions. Based on these examples, we outline genetic and environmental factors contributing to PD and review potential environmental modifiers of penetrance and clinical variability in monogenic and idiopathic PD. We also highlight the... (More)

Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and environmental factors interact to contribute to its etiology. Remarkable progress has been made in deciphering disease etiology through genetic approaches, but there is limited data about how environmental and genetic factors interact to modify penetrance, risk, and disease severity. Here, we provide insights into environmental modifiers of PD, discussing precedents from other neurological and non-neurological conditions. Based on these examples, we outline genetic and environmental factors contributing to PD and review potential environmental modifiers of penetrance and clinical variability in monogenic and idiopathic PD. We also highlight the potential challenges and propose how future studies might tackle these important questions. ANN NEUROL 2022.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Neurology
volume
92
issue
5
pages
10 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:35913124
  • scopus:85138693948
ISSN
0364-5134
DOI
10.1002/ana.26467
language
English
LU publication?
yes
additional info
Funding Information: This work was supported in part by the Global Parkinson's Genetics Program (GP2). GP2 is funded by the Aligning Science Against Parkinson's (ASAP) initiative and implemented by The Michael J. Fox Foundation for Parkinson's Research ( https://gp2.org ). For a complete list of GP2 members see https://gp2.org . This research was supported in part by the Intramural Research Program of the National Institutes of Health (National Institute on Aging, Z01‐AG000949‐02). The Preventive Neurology Unit is funded by the Barts Charity. Publisher Copyright: © 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
id
bdee5884-351b-44e1-86c3-15b1ef6d4507
date added to LUP
2022-10-10 16:26:58
date last changed
2024-06-13 12:24:56
@article{bdee5884-351b-44e1-86c3-15b1ef6d4507,
  abstract     = {{<p>Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and environmental factors interact to contribute to its etiology. Remarkable progress has been made in deciphering disease etiology through genetic approaches, but there is limited data about how environmental and genetic factors interact to modify penetrance, risk, and disease severity. Here, we provide insights into environmental modifiers of PD, discussing precedents from other neurological and non-neurological conditions. Based on these examples, we outline genetic and environmental factors contributing to PD and review potential environmental modifiers of penetrance and clinical variability in monogenic and idiopathic PD. We also highlight the potential challenges and propose how future studies might tackle these important questions. ANN NEUROL 2022.</p>}},
  author       = {{Periñán, Maria Teresa and Brolin, Kajsa and Bandres-Ciga, Sara and Blauwendraat, Cornelis and Klein, Christine and Gan-Or, Ziv and Singleton, Andrew and Gomez-Garre, Pilar and Swanberg, Maria and Mir, Pablo and Noyce, Alastair}},
  issn         = {{0364-5134}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{715--724}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Annals of Neurology}},
  title        = {{Effect Modification between Genes and Environment and Parkinson's Disease Risk}},
  url          = {{http://dx.doi.org/10.1002/ana.26467}},
  doi          = {{10.1002/ana.26467}},
  volume       = {{92}},
  year         = {{2022}},
}