Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Exploring the impact of age on the predictive power of the National Early Warning score (NEWS) 2, and long-term prognosis among patients reviewed by a Rapid Response Team : A prospective, multi-centre study

Thorén, Anna ; Franko, Mikael Andersson ; Joelsson-Alm, Eva ; Rawshani, Araz ; Kahan, Thomas ; Engdahl, Johan ; Jonsson, Martin ; Djärv, Therese and Spångfors, Martin LU orcid (2025) In Resuscitation Plus 21.
Abstract

Aim: To explore the impact of age on the discriminative ability of the National Early Warning Score (NEWS) 2 in prediction of unanticipated Intensive Care Unit (ICU) admission, in-hospital cardiac arrest (IHCA) and mortality within 24 hours of Rapid Response Team (RRT) review. Furthermore, to investigate 30- and 90-day mortality, and the discriminative ability of NEWS 2 in prediction of long-term mortality among RRT-reviewed patients. Methods: Prospective, multi-centre study based on 830 complete cases. Data was collected by RRTs in 24 hospitals between October 2019, and January 2020. All NEWS 2 scores were uniformly calculated by the study team. Age was analysed as a continuous variable, in a spline regression model, and categorized... (More)

Aim: To explore the impact of age on the discriminative ability of the National Early Warning Score (NEWS) 2 in prediction of unanticipated Intensive Care Unit (ICU) admission, in-hospital cardiac arrest (IHCA) and mortality within 24 hours of Rapid Response Team (RRT) review. Furthermore, to investigate 30- and 90-day mortality, and the discriminative ability of NEWS 2 in prediction of long-term mortality among RRT-reviewed patients. Methods: Prospective, multi-centre study based on 830 complete cases. Data was collected by RRTs in 24 hospitals between October 2019, and January 2020. All NEWS 2 scores were uniformly calculated by the study team. Age was analysed as a continuous variable, in a spline regression model, and categorized into five different models, subsequently explored as additive variables to NEWS 2. The discriminative ability of NEWS 2 was evaluated using the Area under the receiver operating characteristics (AUROC). Results: The discriminative ability of NEWS 2 alone in predicting 30-day mortality was weak. Adding age as a covariate improved the predictive performance (AUROC 0.66, 0.62–0.70 to 0.70, 0.65–0.73, p = 0.01, 95 % Confidence Interval). There were differences across age groups, with the best discriminative ability identified among patients aged 45-54 years. The 30- and 90-day mortality was 31% and 33% respectively. Results: Adding age as a covariate improved the discriminative ability of NEWS 2 in the prediction of 30-day mortality among RRT-reviewed patients, with variations observed across age categories. The long- term prognosis of RRT-reviewed patients was poor.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Resuscitation Plus
volume
21
article number
100839
publisher
Elsevier
external identifiers
  • scopus:85212447098
  • pmid:39811470
ISSN
2666-5204
DOI
10.1016/j.resplu.2024.100839
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2024 The Authors
id
be07610b-7201-4f55-8dee-8a5f95abe8eb
date added to LUP
2024-12-26 18:13:56
date last changed
2025-05-02 03:35:09
@article{be07610b-7201-4f55-8dee-8a5f95abe8eb,
  abstract     = {{<p>Aim: To explore the impact of age on the discriminative ability of the National Early Warning Score (NEWS) 2 in prediction of unanticipated Intensive Care Unit (ICU) admission, in-hospital cardiac arrest (IHCA) and mortality within 24 hours of Rapid Response Team (RRT) review. Furthermore, to investigate 30- and 90-day mortality, and the discriminative ability of NEWS 2 in prediction of long-term mortality among RRT-reviewed patients. Methods: Prospective, multi-centre study based on 830 complete cases. Data was collected by RRTs in 24 hospitals between October 2019, and January 2020. All NEWS 2 scores were uniformly calculated by the study team. Age was analysed as a continuous variable, in a spline regression model, and categorized into five different models, subsequently explored as additive variables to NEWS 2. The discriminative ability of NEWS 2 was evaluated using the Area under the receiver operating characteristics (AUROC). Results: The discriminative ability of NEWS 2 alone in predicting 30-day mortality was weak. Adding age as a covariate improved the predictive performance (AUROC 0.66, 0.62–0.70 to 0.70, 0.65–0.73, p = 0.01, 95 % Confidence Interval). There were differences across age groups, with the best discriminative ability identified among patients aged 45-54 years. The 30- and 90-day mortality was 31% and 33% respectively. Results: Adding age as a covariate improved the discriminative ability of NEWS 2 in the prediction of 30-day mortality among RRT-reviewed patients, with variations observed across age categories. The long- term prognosis of RRT-reviewed patients was poor.</p>}},
  author       = {{Thorén, Anna and Franko, Mikael Andersson and Joelsson-Alm, Eva and Rawshani, Araz and Kahan, Thomas and Engdahl, Johan and Jonsson, Martin and Djärv, Therese and Spångfors, Martin}},
  issn         = {{2666-5204}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Resuscitation Plus}},
  title        = {{Exploring the impact of age on the predictive power of the National Early Warning score (NEWS) 2, and long-term prognosis among patients reviewed by a Rapid Response Team : A prospective, multi-centre study}},
  url          = {{http://dx.doi.org/10.1016/j.resplu.2024.100839}},
  doi          = {{10.1016/j.resplu.2024.100839}},
  volume       = {{21}},
  year         = {{2025}},
}