The Glymphatic System : A Beginner’s Guide
(2015) In Neurochemical Research 40(12). p.2583-2599- Abstract
The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system. Besides waste elimination, the glymphatic system also facilitates brain-wide distribution of several compounds, including glucose, lipids, amino acids, growth factors, and neuromodulators. Intriguingly, the glymphatic system function mainly during sleep and is largely disengaged during wakefulness. The biological need for sleep across all species may therefore reflect that the brain must enter a state of activity that enables elimination of potentially neurotoxic waste... (More)
The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system. Besides waste elimination, the glymphatic system also facilitates brain-wide distribution of several compounds, including glucose, lipids, amino acids, growth factors, and neuromodulators. Intriguingly, the glymphatic system function mainly during sleep and is largely disengaged during wakefulness. The biological need for sleep across all species may therefore reflect that the brain must enter a state of activity that enables elimination of potentially neurotoxic waste products, including β-amyloid. Since the concept of the glymphatic system is relatively new, we will here review its basic structural elements, organization, regulation, and functions. We will also discuss recent studies indicating that glymphatic function is suppressed in various diseases and that failure of glymphatic function in turn might contribute to pathology in neurodegenerative disorders, traumatic brain injury and stroke.
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- author
- Jessen, Nadia Aalling ; Munk, Anne Sofie Finmann ; Lundgaard, Iben LU and Nedergaard, Maiken
- publishing date
- 2015-12-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aging, Astrocytes, Cerebrospinal fluid secretion, Neurodegenerative diseases, Perivascular spaces, Sleep, The glymphatic system, Traumatic brain injury, Virchow–Robin spaces
- in
- Neurochemical Research
- volume
- 40
- issue
- 12
- pages
- 17 pages
- publisher
- Springer
- external identifiers
-
- pmid:25947369
- scopus:84949316085
- ISSN
- 0364-3190
- DOI
- 10.1007/s11064-015-1581-6
- language
- English
- LU publication?
- no
- id
- be147551-d8f9-4c96-b989-2781f9b13f4e
- date added to LUP
- 2019-05-16 16:47:21
- date last changed
- 2024-07-10 15:22:32
@article{be147551-d8f9-4c96-b989-2781f9b13f4e,
abstract = {{<p>The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system. Besides waste elimination, the glymphatic system also facilitates brain-wide distribution of several compounds, including glucose, lipids, amino acids, growth factors, and neuromodulators. Intriguingly, the glymphatic system function mainly during sleep and is largely disengaged during wakefulness. The biological need for sleep across all species may therefore reflect that the brain must enter a state of activity that enables elimination of potentially neurotoxic waste products, including β-amyloid. Since the concept of the glymphatic system is relatively new, we will here review its basic structural elements, organization, regulation, and functions. We will also discuss recent studies indicating that glymphatic function is suppressed in various diseases and that failure of glymphatic function in turn might contribute to pathology in neurodegenerative disorders, traumatic brain injury and stroke.</p>}},
author = {{Jessen, Nadia Aalling and Munk, Anne Sofie Finmann and Lundgaard, Iben and Nedergaard, Maiken}},
issn = {{0364-3190}},
keywords = {{Aging; Astrocytes; Cerebrospinal fluid secretion; Neurodegenerative diseases; Perivascular spaces; Sleep; The glymphatic system; Traumatic brain injury; Virchow–Robin spaces}},
language = {{eng}},
month = {{12}},
number = {{12}},
pages = {{2583--2599}},
publisher = {{Springer}},
series = {{Neurochemical Research}},
title = {{The Glymphatic System : A Beginner’s Guide}},
url = {{http://dx.doi.org/10.1007/s11064-015-1581-6}},
doi = {{10.1007/s11064-015-1581-6}},
volume = {{40}},
year = {{2015}},
}