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Association of walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality : A UK Biobank observational study

Yates, Thomas; Zaccardi, Francesco; Dhalwani, Nafeesa N.; Davies, Melanie J.; Bakrania, Kishan; Celis-Morales, Carlos A.; Gill, Jason M.R.; Franks, Paul W. LU and Khunti, Kamlesh (2017) In European Heart Journal 38(43). p.3232-3240
Abstract

Aims: To quantify the association of self-reported walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality. Methods and results: A total of 230 670 women and 190 057 men free from prevalent cancer and cardiovascular disease were included from UK Biobank. Usual walking pace was self-defined as slow, steady/average or brisk. Handgrip strength was assessed by dynamometer. Cox-proportional hazard models were adjusted for social deprivation, ethnicity, employment, medications, alcohol use, diet, physical activity, and television viewing time. Interaction terms investigated whether age, body mass index (BMI), and smoking status modified associations. Over 6.3 years, there were 8598 deaths, 1654 from... (More)

Aims: To quantify the association of self-reported walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality. Methods and results: A total of 230 670 women and 190 057 men free from prevalent cancer and cardiovascular disease were included from UK Biobank. Usual walking pace was self-defined as slow, steady/average or brisk. Handgrip strength was assessed by dynamometer. Cox-proportional hazard models were adjusted for social deprivation, ethnicity, employment, medications, alcohol use, diet, physical activity, and television viewing time. Interaction terms investigated whether age, body mass index (BMI), and smoking status modified associations. Over 6.3 years, there were 8598 deaths, 1654 from cardiovascular disease and 4850 from cancer. Associations of walking pace with mortality were modified by BMI. In women, the hazard ratio (HR) for all-cause mortality in slow compared with fast walkers were 2.16 [95% confidence interval (CI): 1.68-2.77] and 1.31 (1.08-1.60) in the bottom and top BMI tertiles, respectively; corresponding HRs for men were 2.01 (1.68-2.41) and 1.41 (1.20-1.66). Hazard ratios for cardiovascular mortality remained above 1.7 across all categories of BMI in men and women, with modest heterogeneity in men. Handgrip strength was associated with cardiovascular mortality in men only (HR tertile 1 vs. tertile 3 = 1.38; 1.18-1.62), without differences across BMI categories, while associations with all-cause mortality were only seen in men with low BMI. Associations for walking pace and handgrip strength with cancer mortality were less consistent. Conclusion: A simple self-reported measure of slow walking pace could aid risk stratification for all-cause and cardiovascular mortality within the general population.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiorespiratory fitness, Handgrip strength, Mortality, Walking pace
in
European Heart Journal
volume
38
issue
43
pages
9 pages
publisher
Oxford University Press
external identifiers
  • scopus:85040134007
ISSN
0195-668X
DOI
10.1093/eurheartj/ehx449
language
English
LU publication?
yes
id
be624bf3-8c56-4a7f-8ada-7876d83a8a26
date added to LUP
2018-01-23 13:12:26
date last changed
2018-06-03 05:04:31
@article{be624bf3-8c56-4a7f-8ada-7876d83a8a26,
  abstract     = {<p>Aims: To quantify the association of self-reported walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality. Methods and results: A total of 230 670 women and 190 057 men free from prevalent cancer and cardiovascular disease were included from UK Biobank. Usual walking pace was self-defined as slow, steady/average or brisk. Handgrip strength was assessed by dynamometer. Cox-proportional hazard models were adjusted for social deprivation, ethnicity, employment, medications, alcohol use, diet, physical activity, and television viewing time. Interaction terms investigated whether age, body mass index (BMI), and smoking status modified associations. Over 6.3 years, there were 8598 deaths, 1654 from cardiovascular disease and 4850 from cancer. Associations of walking pace with mortality were modified by BMI. In women, the hazard ratio (HR) for all-cause mortality in slow compared with fast walkers were 2.16 [95% confidence interval (CI): 1.68-2.77] and 1.31 (1.08-1.60) in the bottom and top BMI tertiles, respectively; corresponding HRs for men were 2.01 (1.68-2.41) and 1.41 (1.20-1.66). Hazard ratios for cardiovascular mortality remained above 1.7 across all categories of BMI in men and women, with modest heterogeneity in men. Handgrip strength was associated with cardiovascular mortality in men only (HR tertile 1 vs. tertile 3 = 1.38; 1.18-1.62), without differences across BMI categories, while associations with all-cause mortality were only seen in men with low BMI. Associations for walking pace and handgrip strength with cancer mortality were less consistent. Conclusion: A simple self-reported measure of slow walking pace could aid risk stratification for all-cause and cardiovascular mortality within the general population.</p>},
  author       = {Yates, Thomas and Zaccardi, Francesco and Dhalwani, Nafeesa N. and Davies, Melanie J. and Bakrania, Kishan and Celis-Morales, Carlos A. and Gill, Jason M.R. and Franks, Paul W. and Khunti, Kamlesh},
  issn         = {0195-668X},
  keyword      = {Cardiorespiratory fitness,Handgrip strength,Mortality,Walking pace},
  language     = {eng},
  number       = {43},
  pages        = {3232--3240},
  publisher    = {Oxford University Press},
  series       = {European Heart Journal},
  title        = {Association of walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality : A UK Biobank observational study},
  url          = {http://dx.doi.org/10.1093/eurheartj/ehx449},
  volume       = {38},
  year         = {2017},
}