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Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure.

Bungum, Mona LU ; Giwercman, Aleksander LU ; Bungum, Leif LU ; Humaidan, Peter ; Rastkhani, Hamideh LU and Giwercman, Yvonne LU (2010) In Fertility and Sterility 93(1). p.277-279
Abstract
The aim of this study was to determine whether total fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened for mutations in the protein C inhibitor gene by direct sequencing. The main finding was that in men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0).
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Fertility and Sterility
volume
93
issue
1
pages
277 - 279
publisher
Elsevier
external identifiers
  • wos:000273601200041
  • pmid:19765701
  • scopus:72749110925
ISSN
1556-5653
DOI
10.1016/j.fertnstert.2009.07.984
language
English
LU publication?
yes
id
be7405c5-81c7-4024-9c2e-6a41c0bd06de (old id 1483337)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19765701?dopt=Abstract
date added to LUP
2016-04-01 09:49:27
date last changed
2022-01-25 17:01:27
@article{be7405c5-81c7-4024-9c2e-6a41c0bd06de,
  abstract     = {{The aim of this study was to determine whether total fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened for mutations in the protein C inhibitor gene by direct sequencing. The main finding was that in men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0).}},
  author       = {{Bungum, Mona and Giwercman, Aleksander and Bungum, Leif and Humaidan, Peter and Rastkhani, Hamideh and Giwercman, Yvonne}},
  issn         = {{1556-5653}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{277--279}},
  publisher    = {{Elsevier}},
  series       = {{Fertility and Sterility}},
  title        = {{Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure.}},
  url          = {{http://dx.doi.org/10.1016/j.fertnstert.2009.07.984}},
  doi          = {{10.1016/j.fertnstert.2009.07.984}},
  volume       = {{93}},
  year         = {{2010}},
}