Prevalence of atherosclerosis in individuals with prediabetes and diabetes compared to normoglycaemic individuals—a Swedish population-based study
(2023) In Cardiovascular Diabetology 22(1).- Abstract
Background: Patients with type 2 diabetes have an increased risk of death and cardiovascular events and people with diabetes or prediabetes have been found to have increased atherosclerotic burden in the coronary and carotid arteries. This study will estimate the cross-sectional prevalence of atherosclerosis in the coronary and carotid arteries in individuals with prediabetes and diabetes, compared with normoglycaemic individuals in a large population-based cohort. Methods: The 30,154 study participants, 50–64 years, were categorized according to their fasting glycaemic status or self-reported data as normoglycaemic, prediabetes, and previously undetected or known diabetes. Prevalence of affected coronary artery segments, severity of... (More)
Background: Patients with type 2 diabetes have an increased risk of death and cardiovascular events and people with diabetes or prediabetes have been found to have increased atherosclerotic burden in the coronary and carotid arteries. This study will estimate the cross-sectional prevalence of atherosclerosis in the coronary and carotid arteries in individuals with prediabetes and diabetes, compared with normoglycaemic individuals in a large population-based cohort. Methods: The 30,154 study participants, 50–64 years, were categorized according to their fasting glycaemic status or self-reported data as normoglycaemic, prediabetes, and previously undetected or known diabetes. Prevalence of affected coronary artery segments, severity of stenosis and coronary artery calcium score (CACS) were determined by coronary computed tomography angiography. Total atherosclerotic burden was assessed in the 11 clinically most relevant segments using the Segment Involvement Score and as the presence of any coronary atherosclerosis. The presence of atherosclerotic plaque in the carotid arteries was determined by ultrasound examination. Results: Study participants with prediabetes (n = 4804, 16.0%) or diabetes (n = 2282, 7.6%) had greater coronary artery plaque burden, more coronary stenosis and higher CACS than normoglycaemic participants (all, p < 0.01). Among male participants with diabetes 35.3% had CACS ≥ 100 compared to 16.1% among normoglycaemic participants. For women, the corresponding figures were 8.9% vs 6.1%. The prevalence of atherosclerosis in the coronary arteries was higher in participants with previously undetected diabetes than prediabetes, but lower than in patients with known diabetes. The prevalence of any plaque in the carotid arteries was higher in participants with prediabetes or diabetes than in normoglycaemic participants. Conclusions: In this large population-based cohort of currently asymptomatic people, the atherosclerotic burden in the coronary and carotid arteries increased with increasing degree of dysglycaemia. The finding that the atherosclerotic burden in the coronary arteries in the undetected diabetes category was midway between the prediabetes category and patients with known diabetes may have implications for screening strategies and tailored prevention interventions for people with dysglycaemia in the future.
(Less)
- author
- Östgren, Carl Johan
LU
; Otten, Julia
; Festin, Karin
; Angerås, Oskar
; Bergström, Göran
; Cederlund, Kerstin
; Engström, Gunnar
LU
; Eriksson, Maria J.
; Eriksson, Mats
; Fall, Tove
LU
; Gummesson, Anders
; Hagström, Emil
; Hellman, Urban
; James, Stefan K.
; Jernberg, Tomas
; Kihlberg, Johan
; Kylhammar, David
LU
; Markstad, Hanna
LU
; Nilsson, Peter
LU
; Persson, Anders
; Persson, Margaretha
LU
; Pirazzi, Carlo
; Renklint, Rebecka
; Rosengren, Annika
; Söderberg, Stefan
and Sundström, Johan
(Less) - organization
- publishing date
- 2023-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Atherosclerosis, Carotid arteries, Coronary arteries, Coronary computed tomography angiography, Diabetes, Prediabetes
- in
- Cardiovascular Diabetology
- volume
- 22
- issue
- 1
- article number
- 261
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:37759237
- scopus:85172780903
- ISSN
- 1475-2840
- DOI
- 10.1186/s12933-023-01982-6
- language
- English
- LU publication?
- yes
- id
- bed99126-bd43-4568-ae3a-21f1f12590a5
- date added to LUP
- 2023-11-30 15:26:25
- date last changed
- 2024-04-13 16:29:54
@article{bed99126-bd43-4568-ae3a-21f1f12590a5,
abstract = {{<p>Background: Patients with type 2 diabetes have an increased risk of death and cardiovascular events and people with diabetes or prediabetes have been found to have increased atherosclerotic burden in the coronary and carotid arteries. This study will estimate the cross-sectional prevalence of atherosclerosis in the coronary and carotid arteries in individuals with prediabetes and diabetes, compared with normoglycaemic individuals in a large population-based cohort. Methods: The 30,154 study participants, 50–64 years, were categorized according to their fasting glycaemic status or self-reported data as normoglycaemic, prediabetes, and previously undetected or known diabetes. Prevalence of affected coronary artery segments, severity of stenosis and coronary artery calcium score (CACS) were determined by coronary computed tomography angiography. Total atherosclerotic burden was assessed in the 11 clinically most relevant segments using the Segment Involvement Score and as the presence of any coronary atherosclerosis. The presence of atherosclerotic plaque in the carotid arteries was determined by ultrasound examination. Results: Study participants with prediabetes (n = 4804, 16.0%) or diabetes (n = 2282, 7.6%) had greater coronary artery plaque burden, more coronary stenosis and higher CACS than normoglycaemic participants (all, p < 0.01). Among male participants with diabetes 35.3% had CACS ≥ 100 compared to 16.1% among normoglycaemic participants. For women, the corresponding figures were 8.9% vs 6.1%. The prevalence of atherosclerosis in the coronary arteries was higher in participants with previously undetected diabetes than prediabetes, but lower than in patients with known diabetes. The prevalence of any plaque in the carotid arteries was higher in participants with prediabetes or diabetes than in normoglycaemic participants. Conclusions: In this large population-based cohort of currently asymptomatic people, the atherosclerotic burden in the coronary and carotid arteries increased with increasing degree of dysglycaemia. The finding that the atherosclerotic burden in the coronary arteries in the undetected diabetes category was midway between the prediabetes category and patients with known diabetes may have implications for screening strategies and tailored prevention interventions for people with dysglycaemia in the future.</p>}},
author = {{Östgren, Carl Johan and Otten, Julia and Festin, Karin and Angerås, Oskar and Bergström, Göran and Cederlund, Kerstin and Engström, Gunnar and Eriksson, Maria J. and Eriksson, Mats and Fall, Tove and Gummesson, Anders and Hagström, Emil and Hellman, Urban and James, Stefan K. and Jernberg, Tomas and Kihlberg, Johan and Kylhammar, David and Markstad, Hanna and Nilsson, Peter and Persson, Anders and Persson, Margaretha and Pirazzi, Carlo and Renklint, Rebecka and Rosengren, Annika and Söderberg, Stefan and Sundström, Johan}},
issn = {{1475-2840}},
keywords = {{Atherosclerosis; Carotid arteries; Coronary arteries; Coronary computed tomography angiography; Diabetes; Prediabetes}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{Cardiovascular Diabetology}},
title = {{Prevalence of atherosclerosis in individuals with prediabetes and diabetes compared to normoglycaemic individuals—a Swedish population-based study}},
url = {{http://dx.doi.org/10.1186/s12933-023-01982-6}},
doi = {{10.1186/s12933-023-01982-6}},
volume = {{22}},
year = {{2023}},
}