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A differential pattern of gene expression in skeletal muscle of tumor-bearing rats reveals dysregulation of excitation–contraction coupling together with additional muscle alterations

Fontes-Oliveira, Cibely Cristine LU ; Busquets, Sílvia ; Fuster, Gemma ; Ametller, Elisabet ; Figueras, Maite ; Olivan, Mireia ; Toledo, Míriam ; López-Soriano, Francisco J ; Qu, Xiaoyan and Demuth, Jeffrey , et al. (2014) In Muscle and Nerve 49(2). p.48-233
Abstract

INTRODUCTION: Cachexia is a wasting condition that manifests in several types of cancer. The main characteristic of this condition is a profound loss of muscle mass.

METHODS: By using a microarray system, expression of several hundred genes was screened in skeletal muscle of rats bearing a cachexia-inducing tumor, the AH-130 Yoshida ascites hepatoma. This model induced a strong decrease in muscle mass in the tumor-bearing animals, as compared with their healthy counterparts.

RESULTS: The results show important differences in gene expression in EDL skeletal muscle between tumor-bearing animals with cachexia and control animals.

CONCLUSIONS: The differences observed pertain to genes related to intracellular calcium... (More)

INTRODUCTION: Cachexia is a wasting condition that manifests in several types of cancer. The main characteristic of this condition is a profound loss of muscle mass.

METHODS: By using a microarray system, expression of several hundred genes was screened in skeletal muscle of rats bearing a cachexia-inducing tumor, the AH-130 Yoshida ascites hepatoma. This model induced a strong decrease in muscle mass in the tumor-bearing animals, as compared with their healthy counterparts.

RESULTS: The results show important differences in gene expression in EDL skeletal muscle between tumor-bearing animals with cachexia and control animals.

CONCLUSIONS: The differences observed pertain to genes related to intracellular calcium homeostasis and genes involved in the control of mitochondrial oxidative phosphorylation and protein turnover, both at the level of protein synthesis and proteolysis. Assessment of these differences may be a useful tool for the design of novel therapeutic strategies to fight this devastating syndrome.

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publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Cachexia, Calcium, Carcinoma, Hepatocellular, Disease Models, Animal, Energy Metabolism, Excitation Contraction Coupling, Gene Expression Regulation, Neoplastic, Homeostasis, Liver Neoplasms, Male, Muscle, Skeletal, Rats, Rats, Wistar, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
in
Muscle and Nerve
volume
49
issue
2
pages
16 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:23649607
  • scopus:84892493008
ISSN
0148-639X
DOI
10.1002/mus.23893
language
English
LU publication?
no
id
bef3eaac-1392-425e-856a-1f0460d6dd51
date added to LUP
2017-02-28 16:10:19
date last changed
2024-05-26 11:08:31
@article{bef3eaac-1392-425e-856a-1f0460d6dd51,
  abstract     = {{<p>INTRODUCTION: Cachexia is a wasting condition that manifests in several types of cancer. The main characteristic of this condition is a profound loss of muscle mass.</p><p>METHODS: By using a microarray system, expression of several hundred genes was screened in skeletal muscle of rats bearing a cachexia-inducing tumor, the AH-130 Yoshida ascites hepatoma. This model induced a strong decrease in muscle mass in the tumor-bearing animals, as compared with their healthy counterparts.</p><p>RESULTS: The results show important differences in gene expression in EDL skeletal muscle between tumor-bearing animals with cachexia and control animals.</p><p>CONCLUSIONS: The differences observed pertain to genes related to intracellular calcium homeostasis and genes involved in the control of mitochondrial oxidative phosphorylation and protein turnover, both at the level of protein synthesis and proteolysis. Assessment of these differences may be a useful tool for the design of novel therapeutic strategies to fight this devastating syndrome.</p>}},
  author       = {{Fontes-Oliveira, Cibely Cristine and Busquets, Sílvia and Fuster, Gemma and Ametller, Elisabet and Figueras, Maite and Olivan, Mireia and Toledo, Míriam and López-Soriano, Francisco J and Qu, Xiaoyan and Demuth, Jeffrey and Stevens, Paula and Varbanov, Alex and Wang, Feng and Isfort, Robert J and Argilés, Josep M}},
  issn         = {{0148-639X}},
  keywords     = {{Animals; Cachexia; Calcium; Carcinoma, Hepatocellular; Disease Models, Animal; Energy Metabolism; Excitation Contraction Coupling; Gene Expression Regulation, Neoplastic; Homeostasis; Liver Neoplasms; Male; Muscle, Skeletal; Rats; Rats, Wistar; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{48--233}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Muscle and Nerve}},
  title        = {{A differential pattern of gene expression in skeletal muscle of tumor-bearing rats reveals dysregulation of excitation–contraction coupling together with additional muscle alterations}},
  url          = {{http://dx.doi.org/10.1002/mus.23893}},
  doi          = {{10.1002/mus.23893}},
  volume       = {{49}},
  year         = {{2014}},
}