Central nervous system metastases from epithelial ovarian cancer : Prognostic factors and outcome
Cormio, Gennaro ; Loizzi, Vera ; Falagario, Maddalena LU
; Calace, Antonio
; Colamaria, Antonio
; De Tommasi, Antonio
and Selvaggi, Luigi E.
(2011)
In International Journal of Gynecological Cancer
21(5).
p.816-821
- Abstract
Objectives: To analyze the clinicopathological characteristics and prognostic factors associated with survival in patients with central nervous system (CNS) metastases from epithelial ovarian cancer. Methods: Twenty patients with CNS involvement from ovarian carcinoma were evaluated in this retrospective study; their features and survivals were analyzed using Kaplan-Meier and log-rank test methods. Results: The incidence of CNS metastases was 5%, among 400 patients with ovarian cancer treated in our single institution. The median age at diagnosis of the ovarian cancer was 55 years. The median interval to the brain involvement and the median survival were 33 and 18 months, respectively. Prognostic factors associated with survival were... (More)
Objectives: To analyze the clinicopathological characteristics and prognostic factors associated with survival in patients with central nervous system (CNS) metastases from epithelial ovarian cancer. Methods: Twenty patients with CNS involvement from ovarian carcinoma were evaluated in this retrospective study; their features and survivals were analyzed using Kaplan-Meier and log-rank test methods. Results: The incidence of CNS metastases was 5%, among 400 patients with ovarian cancer treated in our single institution. The median age at diagnosis of the ovarian cancer was 55 years. The median interval to the brain involvement and the median survival were 33 and 18 months, respectively. Prognostic factors associated with survival were the International Federation of Gynecology and Obstetrics stage, the surgical resection, the multimodal treatment, and the response after the therapy of the brain metastases. Conclusions: Brain involvement from ovarian cancer is uncommon but is increasing in incidence. Although the prognosis is usually poor, a multimodal approach can result in a long-term remission of the metastases and in an improvement of the overall survival.
(Less)
- author
- Cormio, Gennaro
; Loizzi, Vera
; Falagario, Maddalena
LU
; Calace, Antonio
; Colamaria, Antonio
; De Tommasi, Antonio
and Selvaggi, Luigi E.
- publishing date
- 2011-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Brain involvement, Central nervous system metastases, Ovarian cancer
- in
- International Journal of Gynecological Cancer
- volume
- 21
- issue
- 5
- pages
- 816 - 821
- publisher
- BMJ Publishing Group
- external identifiers
-
- scopus:82955165651
- pmid:21613959
- ISSN
- 1048-891X
- DOI
- 10.1097/IGC.0b013e318216cad0
- language
- English
- LU publication?
- no
- id
- bf111fe8-9ebb-4996-b430-44ee167601a2
- date added to LUP
- 2019-02-16 08:35:41
- date last changed
- 2024-03-02 20:37:50
@article{bf111fe8-9ebb-4996-b430-44ee167601a2,
abstract = {{<p>Objectives: To analyze the clinicopathological characteristics and prognostic factors associated with survival in patients with central nervous system (CNS) metastases from epithelial ovarian cancer. Methods: Twenty patients with CNS involvement from ovarian carcinoma were evaluated in this retrospective study; their features and survivals were analyzed using Kaplan-Meier and log-rank test methods. Results: The incidence of CNS metastases was 5%, among 400 patients with ovarian cancer treated in our single institution. The median age at diagnosis of the ovarian cancer was 55 years. The median interval to the brain involvement and the median survival were 33 and 18 months, respectively. Prognostic factors associated with survival were the International Federation of Gynecology and Obstetrics stage, the surgical resection, the multimodal treatment, and the response after the therapy of the brain metastases. Conclusions: Brain involvement from ovarian cancer is uncommon but is increasing in incidence. Although the prognosis is usually poor, a multimodal approach can result in a long-term remission of the metastases and in an improvement of the overall survival.</p>}},
author = {{Cormio, Gennaro and Loizzi, Vera and Falagario, Maddalena and Calace, Antonio and Colamaria, Antonio and De Tommasi, Antonio and Selvaggi, Luigi E.}},
issn = {{1048-891X}},
keywords = {{Brain involvement; Central nervous system metastases; Ovarian cancer}},
language = {{eng}},
month = {{06}},
number = {{5}},
pages = {{816--821}},
publisher = {{BMJ Publishing Group}},
series = {{International Journal of Gynecological Cancer}},
title = {{Central nervous system metastases from epithelial ovarian cancer : Prognostic factors and outcome}},
url = {{http://dx.doi.org/10.1097/IGC.0b013e318216cad0}},
doi = {{10.1097/IGC.0b013e318216cad0}},
volume = {{21}},
year = {{2011}},
}