Polysomnographic measures of sleep in cocaine dependence and alcohol dependence : Implications for age-related loss of slow wave, stage 3 sleep
(2016) In Addiction 111(6). p.92-1084- Abstract
BACKGROUND AND AIMS: Sleep disturbance is a prominent complaint in cocaine and alcohol dependence. This controlled study evaluated differences of polysomnographic (PSG) sleep in cocaine- and alcohol-dependent subjects, and examined whether substance dependence interacts with age to alter slow wave sleep and rapid eye movement (REM) sleep.
DESIGN: Cross-sectional comparison.
SETTING: Los Angeles and San Diego, CA, USA.
PARTICIPANTS: Abstinent cocaine-dependent subjects (n = 32), abstinent alcohol-dependent subjects (n = 73) and controls (n = 108); mean age 40.3 years recruited 2005-12.
MEASUREMENTS: PSG measures of sleep continuity and sleep architecture primary outcomes of Stage 3 sleep and REM sleep. Covariates... (More)
BACKGROUND AND AIMS: Sleep disturbance is a prominent complaint in cocaine and alcohol dependence. This controlled study evaluated differences of polysomnographic (PSG) sleep in cocaine- and alcohol-dependent subjects, and examined whether substance dependence interacts with age to alter slow wave sleep and rapid eye movement (REM) sleep.
DESIGN: Cross-sectional comparison.
SETTING: Los Angeles and San Diego, CA, USA.
PARTICIPANTS: Abstinent cocaine-dependent subjects (n = 32), abstinent alcohol-dependent subjects (n = 73) and controls (n = 108); mean age 40.3 years recruited 2005-12.
MEASUREMENTS: PSG measures of sleep continuity and sleep architecture primary outcomes of Stage 3 sleep and REM sleep. Covariates included age, ethnicity, education, smoking, body mass index and depressive symptoms.
FINDINGS: Compared with controls, both groups of substance dependent subjects showed loss of Stage 3 sleep (P < 0.001). A substance dependence × age interaction was found in which both cocaine- and alcohol-dependent groups showed loss of Stage 3 sleep at an earlier age than controls (P < 0.05 for all), and cocaine-dependent subjects showed loss of Stage 3 sleep at an earlier age than alcoholics (P < 0.05). Compared with controls, REM sleep was increased in both substance-dependent groups (P < 0.001), and cocaine and alcohol dependence were associated with earlier age-related increase in REM sleep (P < 0.05 for all).
CONCLUSIONS: Cocaine and alcohol dependence appear to be associated with marked disturbances of sleep architecture, including increased rapid eye movement sleep and accelerated age-related loss of slow wave, Stage 3 sleep.
(Less)
- author
- Irwin, Michael R ; Bjurstrom, Martin F LU and Olmstead, Richard
- publishing date
- 2016-06
- type
- Contribution to journal
- publication status
- published
- keywords
- Adult, Age Factors, Aging, Alcoholism, Cocaine-Related Disorders, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Polysomnography, Sleep, Sleep Wake Disorders, Journal Article
- in
- Addiction
- volume
- 111
- issue
- 6
- pages
- 92 - 1084
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:26749502
- scopus:84959418902
- ISSN
- 1360-0443
- DOI
- 10.1111/add.13300
- language
- English
- LU publication?
- no
- id
- bf16ccf9-b264-4c33-8839-a590a8313c2b
- date added to LUP
- 2018-04-26 11:08:34
- date last changed
- 2024-04-01 04:59:47
@article{bf16ccf9-b264-4c33-8839-a590a8313c2b,
abstract = {{<p>BACKGROUND AND AIMS: Sleep disturbance is a prominent complaint in cocaine and alcohol dependence. This controlled study evaluated differences of polysomnographic (PSG) sleep in cocaine- and alcohol-dependent subjects, and examined whether substance dependence interacts with age to alter slow wave sleep and rapid eye movement (REM) sleep.</p><p>DESIGN: Cross-sectional comparison.</p><p>SETTING: Los Angeles and San Diego, CA, USA.</p><p>PARTICIPANTS: Abstinent cocaine-dependent subjects (n = 32), abstinent alcohol-dependent subjects (n = 73) and controls (n = 108); mean age 40.3 years recruited 2005-12.</p><p>MEASUREMENTS: PSG measures of sleep continuity and sleep architecture primary outcomes of Stage 3 sleep and REM sleep. Covariates included age, ethnicity, education, smoking, body mass index and depressive symptoms.</p><p>FINDINGS: Compared with controls, both groups of substance dependent subjects showed loss of Stage 3 sleep (P < 0.001). A substance dependence × age interaction was found in which both cocaine- and alcohol-dependent groups showed loss of Stage 3 sleep at an earlier age than controls (P < 0.05 for all), and cocaine-dependent subjects showed loss of Stage 3 sleep at an earlier age than alcoholics (P < 0.05). Compared with controls, REM sleep was increased in both substance-dependent groups (P < 0.001), and cocaine and alcohol dependence were associated with earlier age-related increase in REM sleep (P < 0.05 for all).</p><p>CONCLUSIONS: Cocaine and alcohol dependence appear to be associated with marked disturbances of sleep architecture, including increased rapid eye movement sleep and accelerated age-related loss of slow wave, Stage 3 sleep.</p>}},
author = {{Irwin, Michael R and Bjurstrom, Martin F and Olmstead, Richard}},
issn = {{1360-0443}},
keywords = {{Adult; Age Factors; Aging; Alcoholism; Cocaine-Related Disorders; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Polysomnography; Sleep; Sleep Wake Disorders; Journal Article}},
language = {{eng}},
number = {{6}},
pages = {{92--1084}},
publisher = {{Wiley-Blackwell}},
series = {{Addiction}},
title = {{Polysomnographic measures of sleep in cocaine dependence and alcohol dependence : Implications for age-related loss of slow wave, stage 3 sleep}},
url = {{http://dx.doi.org/10.1111/add.13300}},
doi = {{10.1111/add.13300}},
volume = {{111}},
year = {{2016}},
}