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Imaging biomarkers in animal models of drug-induced lung injury : A systematic review

Mahmutovic Persson, Irma LU ; von Wachenfeldt, Karin ; Waterton, John C. and Olsson, Lars E. LU orcid (2021) In Journal of Clinical Medicine 10(1). p.1-30
Abstract

For drug-induced interstitial lung disease (DIILD) translational imaging biomarkers are needed to improve detection and management of lung injury and drug-toxicity. Literature was reviewed on animal models in which in vivo imaging was used to detect and assess lung lesions that resembled pathological changes found in DIILD, such as inflammation and fibrosis. A systematic search was carried out using three databases with key words “Animal models”, “Imaging”, “Lung disease”, and “Drugs”. A total of 5749 articles were found, and, based on inclusion criteria, 284 papers were selected for final data extraction, resulting in 182 out of the 284 papers, based on eligibility. Twelve different animal species occurred and nine various imaging... (More)

For drug-induced interstitial lung disease (DIILD) translational imaging biomarkers are needed to improve detection and management of lung injury and drug-toxicity. Literature was reviewed on animal models in which in vivo imaging was used to detect and assess lung lesions that resembled pathological changes found in DIILD, such as inflammation and fibrosis. A systematic search was carried out using three databases with key words “Animal models”, “Imaging”, “Lung disease”, and “Drugs”. A total of 5749 articles were found, and, based on inclusion criteria, 284 papers were selected for final data extraction, resulting in 182 out of the 284 papers, based on eligibility. Twelve different animal species occurred and nine various imaging modalities were used, with two-thirds of the studies being longitudinal. The inducing agents and exposure (dose and duration) differed from non-physiological to clinically relevant doses. The majority of studies reported other biomarkers and/or histological confirmation of the imaging results. Summary of radiotracers and examples of imaging biomarkers were summarized, and the types of animal models and the most used imaging modalities and applications are discussed in this review. Pathologies resembling DIILD, such as inflammation and fibrosis, were described in many papers, but only a few explicitly addressed drug-induced toxicity experiments.

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author
; ; and
author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Computed tomography (CT), Drug toxicity, Drug-induced interstitial lung disease (DIILD), Fibrosis, Imaging biomarkers, Inflammation, Lung imaging, Lung injury models, Magnetic resonance imaging (MRI), Positron emission tomography (PET), Vascular leak
in
Journal of Clinical Medicine
volume
10
issue
1
article number
107
pages
30 pages
publisher
MDPI AG
external identifiers
  • scopus:85112259213
  • pmid:33396865
ISSN
2077-0383
DOI
10.3390/jcm10010107
language
English
LU publication?
yes
id
bf19bdb0-ec22-47bb-855c-cbc97152330e
date added to LUP
2022-03-22 17:18:22
date last changed
2024-06-21 03:39:22
@article{bf19bdb0-ec22-47bb-855c-cbc97152330e,
  abstract     = {{<p>For drug-induced interstitial lung disease (DIILD) translational imaging biomarkers are needed to improve detection and management of lung injury and drug-toxicity. Literature was reviewed on animal models in which in vivo imaging was used to detect and assess lung lesions that resembled pathological changes found in DIILD, such as inflammation and fibrosis. A systematic search was carried out using three databases with key words “Animal models”, “Imaging”, “Lung disease”, and “Drugs”. A total of 5749 articles were found, and, based on inclusion criteria, 284 papers were selected for final data extraction, resulting in 182 out of the 284 papers, based on eligibility. Twelve different animal species occurred and nine various imaging modalities were used, with two-thirds of the studies being longitudinal. The inducing agents and exposure (dose and duration) differed from non-physiological to clinically relevant doses. The majority of studies reported other biomarkers and/or histological confirmation of the imaging results. Summary of radiotracers and examples of imaging biomarkers were summarized, and the types of animal models and the most used imaging modalities and applications are discussed in this review. Pathologies resembling DIILD, such as inflammation and fibrosis, were described in many papers, but only a few explicitly addressed drug-induced toxicity experiments.</p>}},
  author       = {{Mahmutovic Persson, Irma and von Wachenfeldt, Karin and Waterton, John C. and Olsson, Lars E.}},
  issn         = {{2077-0383}},
  keywords     = {{Computed tomography (CT); Drug toxicity; Drug-induced interstitial lung disease (DIILD); Fibrosis; Imaging biomarkers; Inflammation; Lung imaging; Lung injury models; Magnetic resonance imaging (MRI); Positron emission tomography (PET); Vascular leak}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{1--30}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of Clinical Medicine}},
  title        = {{Imaging biomarkers in animal models of drug-induced lung injury : A systematic review}},
  url          = {{http://dx.doi.org/10.3390/jcm10010107}},
  doi          = {{10.3390/jcm10010107}},
  volume       = {{10}},
  year         = {{2021}},
}