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Traceable calibration with 177Lu and comparison of activity meters at hospitals in Norway and Sweden

Hindorf, Cecilia LU ; Jessen, Lovisa LU ; Kapidzic, Selma Curkic LU ; Blakkisrud, Johan ; Dalmo, Johanna ; Engelsen, Ola ; Gustafsson, Johan LU ; Sandström, Mattias ; Sæterstøl, Jostein and Gleisner, Katarina Sjögreen LU (2023) In Physica Medica 116.
Abstract

Introduction: The activity meter is used to determine the activity of delivered radiopharmaceuticals, administered activity to patients and reference activity when gamma-cameras are calibrated prior to imaged-based dosimetry. The aim is to describe a procedure for cross-calibration of activity meters at different clinical sites, and report on 177Lu activity results when using factory-set calibration factors compared to when calibration is performed with traceability to a primary standard. Methods: Thirty activity meters placed at seven hospitals in Norway and Sweden from four manufacturers: Capintec, Commecer, NuviaTech and Veenstra were included. A stock solution with 177Lu was prepared at the local sites and... (More)

Introduction: The activity meter is used to determine the activity of delivered radiopharmaceuticals, administered activity to patients and reference activity when gamma-cameras are calibrated prior to imaged-based dosimetry. The aim is to describe a procedure for cross-calibration of activity meters at different clinical sites, and report on 177Lu activity results when using factory-set calibration factors compared to when calibration is performed with traceability to a primary standard. Methods: Thirty activity meters placed at seven hospitals in Norway and Sweden from four manufacturers: Capintec, Commecer, NuviaTech and Veenstra were included. A stock solution with 177Lu was prepared at the local sites and measured in each activity meter with factory settings. The solution was shipped to the reference site at Lund University for measurements in a secondary standard activity meter. Deviations between local and reference activity measurements were determined for three geometries: 25-mL vial, 10-mL syringe and 1-mL syringe. Results: The median of the deviations was 6.4 % for the 25 mL vial, 5.9 % for the 10 mL syringe and 6.8 % for the 1 mL syringe. The median of the deviations for the 25 mL vial, was 1.5 % for activity meters from Capintec, 7.0 % for Comecer, 11.0 % for NuviaTech and 2.4 % for Veenstra. The majority of the deviations were positive and the maximum deviation was 14.5 %. Conclusion: The activity of 177Lu measured in an activity meter with factory-set dial settings may yield deviations up to 14.5%, compared to activities measured with traceability to a primary standard. This would imply an undertreatment of patients.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
177-Lutetium, Activity meter, Metrological traceability, Radionuclide therapy
in
Physica Medica
volume
116
article number
103170
publisher
ISTITUTI EDITORIALI E POLGRAFICI INTERNAZIONALI
external identifiers
  • pmid:37989044
  • scopus:85178304995
ISSN
1120-1797
DOI
10.1016/j.ejmp.2023.103170
language
English
LU publication?
yes
id
bf2b243b-00fd-484d-9cb9-28ab47c3ecff
date added to LUP
2023-12-29 10:11:28
date last changed
2024-04-13 15:27:20
@article{bf2b243b-00fd-484d-9cb9-28ab47c3ecff,
  abstract     = {{<p>Introduction: The activity meter is used to determine the activity of delivered radiopharmaceuticals, administered activity to patients and reference activity when gamma-cameras are calibrated prior to imaged-based dosimetry. The aim is to describe a procedure for cross-calibration of activity meters at different clinical sites, and report on <sup>177</sup>Lu activity results when using factory-set calibration factors compared to when calibration is performed with traceability to a primary standard. Methods: Thirty activity meters placed at seven hospitals in Norway and Sweden from four manufacturers: Capintec, Commecer, NuviaTech and Veenstra were included. A stock solution with <sup>177</sup>Lu was prepared at the local sites and measured in each activity meter with factory settings. The solution was shipped to the reference site at Lund University for measurements in a secondary standard activity meter. Deviations between local and reference activity measurements were determined for three geometries: 25-mL vial, 10-mL syringe and 1-mL syringe. Results: The median of the deviations was 6.4 % for the 25 mL vial, 5.9 % for the 10 mL syringe and 6.8 % for the 1 mL syringe. The median of the deviations for the 25 mL vial, was 1.5 % for activity meters from Capintec, 7.0 % for Comecer, 11.0 % for NuviaTech and 2.4 % for Veenstra. The majority of the deviations were positive and the maximum deviation was 14.5 %. Conclusion: The activity of <sup>177</sup>Lu measured in an activity meter with factory-set dial settings may yield deviations up to 14.5%, compared to activities measured with traceability to a primary standard. This would imply an undertreatment of patients.</p>}},
  author       = {{Hindorf, Cecilia and Jessen, Lovisa and Kapidzic, Selma Curkic and Blakkisrud, Johan and Dalmo, Johanna and Engelsen, Ola and Gustafsson, Johan and Sandström, Mattias and Sæterstøl, Jostein and Gleisner, Katarina Sjögreen}},
  issn         = {{1120-1797}},
  keywords     = {{177-Lutetium; Activity meter; Metrological traceability; Radionuclide therapy}},
  language     = {{eng}},
  publisher    = {{ISTITUTI EDITORIALI E POLGRAFICI INTERNAZIONALI}},
  series       = {{Physica Medica}},
  title        = {{Traceable calibration with <sup>177</sup>Lu and comparison of activity meters at hospitals in Norway and Sweden}},
  url          = {{http://dx.doi.org/10.1016/j.ejmp.2023.103170}},
  doi          = {{10.1016/j.ejmp.2023.103170}},
  volume       = {{116}},
  year         = {{2023}},
}