Predicting cardiotoxicity propensity of the novel iodinated contrast medium GE-145: ventricular fibrillation during left coronary arteriography in pigs.
(2010) In Acta Radiologica 51. p.1007-1013- Abstract
- Background: Severe side effects caused by iodinated radiographic contrast media (CM) are rare, but can occur in high risk patients and during percutaneous coronary intervention. To minimize this risk a new nonionic CM with low inherent osmolality has been designed, giving room for a relatively high concentration of favorable electrolytes in the isotonic formulation. Purpose: To test a new radiographic CM (GE-145) in a pig model of cardiotoxicity by comparing its ventricular fibrillation (VF) propensity and hemodynamic effects to that of iodixanol. Material and Methods: Test agents were injected into the left anterior descending coronary artery (LAD) of pigs through an inflated balloon catheter (injection volume 25 ml, injection rate 0.4... (More)
- Background: Severe side effects caused by iodinated radiographic contrast media (CM) are rare, but can occur in high risk patients and during percutaneous coronary intervention. To minimize this risk a new nonionic CM with low inherent osmolality has been designed, giving room for a relatively high concentration of favorable electrolytes in the isotonic formulation. Purpose: To test a new radiographic CM (GE-145) in a pig model of cardiotoxicity by comparing its ventricular fibrillation (VF) propensity and hemodynamic effects to that of iodixanol. Material and Methods: Test agents were injected into the left anterior descending coronary artery (LAD) of pigs through an inflated balloon catheter (injection volume 25 ml, injection rate 0.4 ml/s, maximum injection time 62.5 s). Series 1: GE-145 (338 mg I/ml) + 45 mM NaCl and iodixanol (321 mg I/ml) + 19 mM NaCl were injected in five pigs. Series 2: GE-145 (320 mg I/ml) + 45 mM NaCl + 0.1, 0.3, or 0.7 mM CaCl(2) and iodixanol (320 mg I/ml) + 19 mM NaCl + 0.3 mM CaCl(2) (Visipaque) were injected in six pigs. Results: Iodixanol + NaCl caused VF in 6 of 13 injections (46%) after 60.3+/-7.5 s (mean +/- SD). GE-145 + NaCl did not cause any VF in 13 injections (0%) (P<0.05). Iodixanol + 19 mM NaCl + 0.3 mM CaCl(2) caused VF in 9 of 9 injections (100%) after 61+/-4 s. GE-145 + 45 mM NaCl + 0.1, 0.3, or 0.7 mM CaCl(2) did not cause any VF during or after 9 injections of each agent (0%) (P<0.05). The least hemodynamic effects were seen with GE-145 + 45 mM NaCl + 0.7 mM CaCl(2). Conclusion: In this model of direct administration of CM into the LAD of anesthetized pigs, the tested GE-145 formulations had a significantly lower propensity to induce VF than iodixanol with electrolytes. Favorable hemodynamic properties of GE-145 can be achieved by optimizing concentrations of sodium and calcium. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1664960
- author
- Chai, Chun-Ming LU ; Rasmussen, Henrik ; Eriksen, Morten ; Hvoslef, Anne-Marie ; Evans, Paul ; Newton, Ben B and Videm, Signe
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Radiologica
- volume
- 51
- pages
- 1007 - 1013
- publisher
- SAGE Publications
- external identifiers
-
- wos:000283058900009
- pmid:20799918
- scopus:77958030078
- pmid:20799918
- ISSN
- 1600-0455
- DOI
- 10.3109/02841851.2010.504743
- language
- English
- LU publication?
- yes
- id
- bf497c31-99e5-49fc-a4bb-3b44756ccf64 (old id 1664960)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20799918?dopt=Abstract
- date added to LUP
- 2016-04-01 13:50:30
- date last changed
- 2022-01-27 21:27:07
@article{bf497c31-99e5-49fc-a4bb-3b44756ccf64,
abstract = {{Background: Severe side effects caused by iodinated radiographic contrast media (CM) are rare, but can occur in high risk patients and during percutaneous coronary intervention. To minimize this risk a new nonionic CM with low inherent osmolality has been designed, giving room for a relatively high concentration of favorable electrolytes in the isotonic formulation. Purpose: To test a new radiographic CM (GE-145) in a pig model of cardiotoxicity by comparing its ventricular fibrillation (VF) propensity and hemodynamic effects to that of iodixanol. Material and Methods: Test agents were injected into the left anterior descending coronary artery (LAD) of pigs through an inflated balloon catheter (injection volume 25 ml, injection rate 0.4 ml/s, maximum injection time 62.5 s). Series 1: GE-145 (338 mg I/ml) + 45 mM NaCl and iodixanol (321 mg I/ml) + 19 mM NaCl were injected in five pigs. Series 2: GE-145 (320 mg I/ml) + 45 mM NaCl + 0.1, 0.3, or 0.7 mM CaCl(2) and iodixanol (320 mg I/ml) + 19 mM NaCl + 0.3 mM CaCl(2) (Visipaque) were injected in six pigs. Results: Iodixanol + NaCl caused VF in 6 of 13 injections (46%) after 60.3+/-7.5 s (mean +/- SD). GE-145 + NaCl did not cause any VF in 13 injections (0%) (P<0.05). Iodixanol + 19 mM NaCl + 0.3 mM CaCl(2) caused VF in 9 of 9 injections (100%) after 61+/-4 s. GE-145 + 45 mM NaCl + 0.1, 0.3, or 0.7 mM CaCl(2) did not cause any VF during or after 9 injections of each agent (0%) (P<0.05). The least hemodynamic effects were seen with GE-145 + 45 mM NaCl + 0.7 mM CaCl(2). Conclusion: In this model of direct administration of CM into the LAD of anesthetized pigs, the tested GE-145 formulations had a significantly lower propensity to induce VF than iodixanol with electrolytes. Favorable hemodynamic properties of GE-145 can be achieved by optimizing concentrations of sodium and calcium.}},
author = {{Chai, Chun-Ming and Rasmussen, Henrik and Eriksen, Morten and Hvoslef, Anne-Marie and Evans, Paul and Newton, Ben B and Videm, Signe}},
issn = {{1600-0455}},
language = {{eng}},
pages = {{1007--1013}},
publisher = {{SAGE Publications}},
series = {{Acta Radiologica}},
title = {{Predicting cardiotoxicity propensity of the novel iodinated contrast medium GE-145: ventricular fibrillation during left coronary arteriography in pigs.}},
url = {{http://dx.doi.org/10.3109/02841851.2010.504743}},
doi = {{10.3109/02841851.2010.504743}},
volume = {{51}},
year = {{2010}},
}