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The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study

Lin, Yi Ting ; Sayols-Baixeras, Sergi ; Baldanzi, Gabriel ; Dekkers, Koen F. ; Hammar, Ulf ; Nguyen, Diem ; Nielsen, Nynne ; Eklund, Aron C. ; Varotsis, Georgios and Holm, Jacob B. , et al. (2025) In Communications medicine 5(1).
Abstract

Background: There is mounting evidence supporting the role of the microbiota in hypertension from experimental studies and population-based studies. We aimed to investigate the relationship between specific characteristics of the gut microbiome and 24-h ambulatory blood pressure measurements. Methods: The association of gut microbial species and microbial functions, determined by shotgun metagenomic sequencing of fecal samples, with 24-h ambulatory blood pressure measurements in 3695 participants and office blood pressure was assessed in multivariable-adjusted models in 2770 participants without antihypertensive medication from the Swedish CArdioPulmonary bioImage Study. Results: Gut microbiome alpha diversity was negatively associated... (More)

Background: There is mounting evidence supporting the role of the microbiota in hypertension from experimental studies and population-based studies. We aimed to investigate the relationship between specific characteristics of the gut microbiome and 24-h ambulatory blood pressure measurements. Methods: The association of gut microbial species and microbial functions, determined by shotgun metagenomic sequencing of fecal samples, with 24-h ambulatory blood pressure measurements in 3695 participants and office blood pressure was assessed in multivariable-adjusted models in 2770 participants without antihypertensive medication from the Swedish CArdioPulmonary bioImage Study. Results: Gut microbiome alpha diversity was negatively associated with diastolic blood pressure variability. Additionally, four microbial species were associated with at least one of the 24-h blood pressure traits. Streptococcus sp001556435 was associated with higher systolic blood pressure, Intestinimonas massiliensis and Dysosmobacter sp001916835 with lower systolic blood pressure, Dysosmobacter sp001916835 with lower diastolic blood pressure, and ER4 sp900317525 with lower systolic blood pressure variability. Moreover, office blood pressure data from a subsample without ambulatory blood pressure measurements replicated the association of Intestinimonas massiliensis with systolic blood pressure and Dysosmobacter sp001916835 with diastolic blood pressure. Species associated with 24-h blood pressure were linked to a similar pattern of metabolites. Conclusions: In this large cross-sectional analysis, gut microbiome alpha diversity negatively associates with diastolic blood pressure variability, and four gut microbial species associate with 24-h blood pressure traits.

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type
Contribution to journal
publication status
published
subject
in
Communications medicine
volume
5
issue
1
article number
276
publisher
Nature Publishing Group
external identifiers
  • scopus:105010013479
  • pmid:40624247
ISSN
2730-664X
DOI
10.1038/s43856-025-00980-x
language
English
LU publication?
yes
id
bf88aed0-6c33-47c3-9373-5790aec723ce
date added to LUP
2025-10-21 13:33:08
date last changed
2025-11-04 14:30:33
@article{bf88aed0-6c33-47c3-9373-5790aec723ce,
  abstract     = {{<p>Background: There is mounting evidence supporting the role of the microbiota in hypertension from experimental studies and population-based studies. We aimed to investigate the relationship between specific characteristics of the gut microbiome and 24-h ambulatory blood pressure measurements. Methods: The association of gut microbial species and microbial functions, determined by shotgun metagenomic sequencing of fecal samples, with 24-h ambulatory blood pressure measurements in 3695 participants and office blood pressure was assessed in multivariable-adjusted models in 2770 participants without antihypertensive medication from the Swedish CArdioPulmonary bioImage Study. Results: Gut microbiome alpha diversity was negatively associated with diastolic blood pressure variability. Additionally, four microbial species were associated with at least one of the 24-h blood pressure traits. Streptococcus sp001556435 was associated with higher systolic blood pressure, Intestinimonas massiliensis and Dysosmobacter sp001916835 with lower systolic blood pressure, Dysosmobacter sp001916835 with lower diastolic blood pressure, and ER4 sp900317525 with lower systolic blood pressure variability. Moreover, office blood pressure data from a subsample without ambulatory blood pressure measurements replicated the association of Intestinimonas massiliensis with systolic blood pressure and Dysosmobacter sp001916835 with diastolic blood pressure. Species associated with 24-h blood pressure were linked to a similar pattern of metabolites. Conclusions: In this large cross-sectional analysis, gut microbiome alpha diversity negatively associates with diastolic blood pressure variability, and four gut microbial species associate with 24-h blood pressure traits.</p>}},
  author       = {{Lin, Yi Ting and Sayols-Baixeras, Sergi and Baldanzi, Gabriel and Dekkers, Koen F. and Hammar, Ulf and Nguyen, Diem and Nielsen, Nynne and Eklund, Aron C. and Varotsis, Georgios and Holm, Jacob B. and Nielsen, H. Bjørn and Lind, Lars and Bergström, Göran and Smith, J. Gustav and Engström, Gunnar and Ärnlöv, Johan and Sundström, Johan and Orho-Melander, Marju and Fall, Tove}},
  issn         = {{2730-664X}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Communications medicine}},
  title        = {{The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study}},
  url          = {{http://dx.doi.org/10.1038/s43856-025-00980-x}},
  doi          = {{10.1038/s43856-025-00980-x}},
  volume       = {{5}},
  year         = {{2025}},
}