A cross-sectional magnetic resonance imaging study of factors influencing growth plate closure in adolescents and young adults
(2021) In Acta Paediatrica, International Journal of Paediatrics 110(4). p.1249-1256- Abstract
Aim: To assess growth plate fusion by magnetic resonance imaging (MRI) and evaluate the correlation with sex, age, pubertal development, physical activity and BMI. Methods: Wrist, knee and ankle of 958 healthy subjects aged 14.0-21.5 years old were examined using MRI and graded by two radiologists. Correlations of growth plate fusion score with age, pubertal development, physical activity and BMI were assessed. Results: Complete growth plate fusion occurred in 75%, 85%, 97%, 98%, 98% and 90%, 97%, 95%, 97%, 98% (radius, femur, proximal- and distal tibia and calcaneus) in 17-year-old females and 19-year-old males, respectively. Complete fusion occurs approximately 2 years earlier in girls than in boys. Pubertal development correlated... (More)
Aim: To assess growth plate fusion by magnetic resonance imaging (MRI) and evaluate the correlation with sex, age, pubertal development, physical activity and BMI. Methods: Wrist, knee and ankle of 958 healthy subjects aged 14.0-21.5 years old were examined using MRI and graded by two radiologists. Correlations of growth plate fusion score with age, pubertal development, physical activity and BMI were assessed. Results: Complete growth plate fusion occurred in 75%, 85%, 97%, 98%, 98% and 90%, 97%, 95%, 97%, 98% (radius, femur, proximal- and distal tibia and calcaneus) in 17-year-old females and 19-year-old males, respectively. Complete fusion occurs approximately 2 years earlier in girls than in boys. Pubertal development correlated with growth plate fusion score (ρ = 0.514-0.598 for the different growth plate sites) but regular physical activity did not. BMI also correlated with growth plate fusion (ρ = 0.186-0.384). Stratified logistic regression showed increased odds ratio (OR F: 2.65-8.71; M: 1.71-4.03) for growth plate fusion of obese or overweight subects versus normal-weight subjects. Inter-observer agreement was high (Κ = 0.87-0.94). Conclusion: Growth plate fusion can be assessed by MRI; occurs in an ascending order, from the foot to the wrist; and is significantly influenced by sex, pubertal development and BMI, but not by physical activity.
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- author
- Kvist, Ola ; Luiza Dallora, Ana ; Nilsson, Ola ; Anderberg, Peter LU ; Sanmartin Berglund, Johan ; Flodmark, Carl Erik LU and Diaz, Sandra LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- growth plate, magnetic resonance imaging, maturation process, obesity, puberty
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 110
- issue
- 4
- pages
- 1249 - 1256
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85094635288
- pmid:33047349
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.15617
- language
- English
- LU publication?
- yes
- id
- bfd43493-4a48-403f-91c8-b3032878850d
- date added to LUP
- 2020-11-17 13:10:31
- date last changed
- 2025-01-10 22:02:22
@article{bfd43493-4a48-403f-91c8-b3032878850d,
abstract = {{<p>Aim: To assess growth plate fusion by magnetic resonance imaging (MRI) and evaluate the correlation with sex, age, pubertal development, physical activity and BMI. Methods: Wrist, knee and ankle of 958 healthy subjects aged 14.0-21.5 years old were examined using MRI and graded by two radiologists. Correlations of growth plate fusion score with age, pubertal development, physical activity and BMI were assessed. Results: Complete growth plate fusion occurred in 75%, 85%, 97%, 98%, 98% and 90%, 97%, 95%, 97%, 98% (radius, femur, proximal- and distal tibia and calcaneus) in 17-year-old females and 19-year-old males, respectively. Complete fusion occurs approximately 2 years earlier in girls than in boys. Pubertal development correlated with growth plate fusion score (ρ = 0.514-0.598 for the different growth plate sites) but regular physical activity did not. BMI also correlated with growth plate fusion (ρ = 0.186-0.384). Stratified logistic regression showed increased odds ratio (OR F: 2.65-8.71; M: 1.71-4.03) for growth plate fusion of obese or overweight subects versus normal-weight subjects. Inter-observer agreement was high (Κ = 0.87-0.94). Conclusion: Growth plate fusion can be assessed by MRI; occurs in an ascending order, from the foot to the wrist; and is significantly influenced by sex, pubertal development and BMI, but not by physical activity.</p>}},
author = {{Kvist, Ola and Luiza Dallora, Ana and Nilsson, Ola and Anderberg, Peter and Sanmartin Berglund, Johan and Flodmark, Carl Erik and Diaz, Sandra}},
issn = {{0803-5253}},
keywords = {{growth plate; magnetic resonance imaging; maturation process; obesity; puberty}},
language = {{eng}},
number = {{4}},
pages = {{1249--1256}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica, International Journal of Paediatrics}},
title = {{A cross-sectional magnetic resonance imaging study of factors influencing growth plate closure in adolescents and young adults}},
url = {{http://dx.doi.org/10.1111/apa.15617}},
doi = {{10.1111/apa.15617}},
volume = {{110}},
year = {{2021}},
}