PDGF-B Is Required for Development of the Glymphatic System
(2019) In Cell Reports p.3-2969- Abstract
The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse... (More)
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The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb
ret/ret
suppressed the development of the glymphatic system, whose functions remained suppressed in adulthood compared with wild-type mice. These experiments map the natural development of the glymphatic system in mice and define a critical role of PDGF-B in the development of perivascular CSF transport.
- author
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aquaporin 4, astrocytes, cerebrospinal fluid, glymphatic system, platelet-derived growth factor B, postnatal development
- in
- Cell Reports
- pages
- 3 - 2969
- publisher
- Cell Press
- external identifiers
-
- pmid:30865886
- scopus:85062401630
- ISSN
- 2211-1247
- DOI
- 10.1016/j.celrep.2019.02.050
- language
- English
- LU publication?
- yes
- id
- bff239d6-b21e-4fe9-8fb3-e626a1bb694a
- date added to LUP
- 2019-03-14 13:26:33
- date last changed
- 2024-03-19 02:59:29
@article{bff239d6-b21e-4fe9-8fb3-e626a1bb694a, abstract = {{<p><br> The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb <br> <sup>ret/ret</sup><br> suppressed the development of the glymphatic system, whose functions remained suppressed in adulthood compared with wild-type mice. These experiments map the natural development of the glymphatic system in mice and define a critical role of PDGF-B in the development of perivascular CSF transport. <br> </p>}}, author = {{Munk, Anne Sofie and Wang, Wei and Bèchet, Nicholas Burdon and Eltanahy, Ahmed M. and Cheng, Anne Xiaoan and Sigurdsson, Björn and Benraiss, Abdellatif and Mäe, Maarja A. and Kress, Benjamin Travis and Kelley, Douglas H. and Betsholtz, Christer and Møllgård, Kjeld and Meissner, Anja and Nedergaard, Maiken and Lundgaard, Iben}}, issn = {{2211-1247}}, keywords = {{aquaporin 4; astrocytes; cerebrospinal fluid; glymphatic system; platelet-derived growth factor B; postnatal development}}, language = {{eng}}, pages = {{3--2969}}, publisher = {{Cell Press}}, series = {{Cell Reports}}, title = {{PDGF-B Is Required for Development of the Glymphatic System}}, url = {{http://dx.doi.org/10.1016/j.celrep.2019.02.050}}, doi = {{10.1016/j.celrep.2019.02.050}}, year = {{2019}}, }