The Role of Airway Inflammation and Bronchial Hyperresponsiveness in Athlete's Asthma
(2018) In Medicine and Science in Sports and Exercise 50(4). p.659-666- Abstract
Purpose Asthma is frequently reported in endurance athletes. The aim of the present study was to assess the long-term airway inflammatory response to endurance exercise in high-level athletes with and without asthma. Methods In a cross-sectional design, 20 asthmatic athletes (10 swimmers and 10 cross-country skiers), 19 athletes without asthma (10 swimmers and 9 cross-country skiers), and 24 healthy nonathletes completed methacholine bronchial challenge, lung function tests, and sputum induction on two separate days. All athletes competed on a national or international level and exercised ≥10 h·wk-1. The nonathletes exercised ≤5 h·wk-1 and reported no previous lung disease. Bronchial hyperresponsiveness (BHR) was... (More)
Purpose Asthma is frequently reported in endurance athletes. The aim of the present study was to assess the long-term airway inflammatory response to endurance exercise in high-level athletes with and without asthma. Methods In a cross-sectional design, 20 asthmatic athletes (10 swimmers and 10 cross-country skiers), 19 athletes without asthma (10 swimmers and 9 cross-country skiers), and 24 healthy nonathletes completed methacholine bronchial challenge, lung function tests, and sputum induction on two separate days. All athletes competed on a national or international level and exercised ≥10 h·wk-1. The nonathletes exercised ≤5 h·wk-1 and reported no previous lung disease. Bronchial hyperresponsiveness (BHR) was defined as a methacholine provocation dose causing 20% decrease in the forced expiratory volume in 1 s of ≤8 μmol. Results BHR was present in 13 asthmatic athletes (62%), 11 healthy athletes (58%), and 8 healthy nonathletes (32%), and the prevalence differed among groups (P = 0.005). Sputum inflammatory and epithelial cell counts did not differ between groups and were within the normal range. Median (25th to 75th percentiles) sputum interleukin-8 was elevated in both asthmatic (378.4 [167.0-1123.4]) and healthy (340.2 [175.5-892.4]) athletes as compared with healthy nonathletes (216.6 [129.5-314.0], P = 0.02). No correlations were found between provocation dose causing 20% decrease and sputum cell counts. Conclusion Independent of asthma diagnosis, a high occurrence of BHR and an increased sputum interleukin-8 were found in athletes as compared with nonathletes. Airway inflammation or epithelial damage was not related to BHR.
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- author
- Stang, Julie ; Sikkeland, Liv Ingunn Bjoner ; Tufvesson, Ellen LU ; Holm, Are Martin ; Stensrud, Trine and Carlsen, Kai Håkon
- organization
- publishing date
- 2018-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CROSS-COUNTRY SKIERS, EPITHELIAL DAMAGE, EXERCISE, INDUCED SPUTUM, METHACHOLINE, SWIMMERS
- in
- Medicine and Science in Sports and Exercise
- volume
- 50
- issue
- 4
- pages
- 8 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:29189668
- scopus:85044026984
- ISSN
- 0195-9131
- DOI
- 10.1249/MSS.0000000000001478
- language
- English
- LU publication?
- yes
- id
- c033318a-f32c-4016-ba0c-3625ff869829
- date added to LUP
- 2018-04-04 13:11:10
- date last changed
- 2024-06-24 12:25:00
@article{c033318a-f32c-4016-ba0c-3625ff869829,
abstract = {{<p>Purpose Asthma is frequently reported in endurance athletes. The aim of the present study was to assess the long-term airway inflammatory response to endurance exercise in high-level athletes with and without asthma. Methods In a cross-sectional design, 20 asthmatic athletes (10 swimmers and 10 cross-country skiers), 19 athletes without asthma (10 swimmers and 9 cross-country skiers), and 24 healthy nonathletes completed methacholine bronchial challenge, lung function tests, and sputum induction on two separate days. All athletes competed on a national or international level and exercised ≥10 h·wk<sup>-1</sup>. The nonathletes exercised ≤5 h·wk<sup>-1</sup> and reported no previous lung disease. Bronchial hyperresponsiveness (BHR) was defined as a methacholine provocation dose causing 20% decrease in the forced expiratory volume in 1 s of ≤8 μmol. Results BHR was present in 13 asthmatic athletes (62%), 11 healthy athletes (58%), and 8 healthy nonathletes (32%), and the prevalence differed among groups (P = 0.005). Sputum inflammatory and epithelial cell counts did not differ between groups and were within the normal range. Median (25th to 75th percentiles) sputum interleukin-8 was elevated in both asthmatic (378.4 [167.0-1123.4]) and healthy (340.2 [175.5-892.4]) athletes as compared with healthy nonathletes (216.6 [129.5-314.0], P = 0.02). No correlations were found between provocation dose causing 20% decrease and sputum cell counts. Conclusion Independent of asthma diagnosis, a high occurrence of BHR and an increased sputum interleukin-8 were found in athletes as compared with nonathletes. Airway inflammation or epithelial damage was not related to BHR.</p>}},
author = {{Stang, Julie and Sikkeland, Liv Ingunn Bjoner and Tufvesson, Ellen and Holm, Are Martin and Stensrud, Trine and Carlsen, Kai Håkon}},
issn = {{0195-9131}},
keywords = {{CROSS-COUNTRY SKIERS; EPITHELIAL DAMAGE; EXERCISE; INDUCED SPUTUM; METHACHOLINE; SWIMMERS}},
language = {{eng}},
month = {{04}},
number = {{4}},
pages = {{659--666}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Medicine and Science in Sports and Exercise}},
title = {{The Role of Airway Inflammation and Bronchial Hyperresponsiveness in Athlete's Asthma}},
url = {{http://dx.doi.org/10.1249/MSS.0000000000001478}},
doi = {{10.1249/MSS.0000000000001478}},
volume = {{50}},
year = {{2018}},
}