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Suppressed antibody and interleukin-6 responses to acute pyelonephritis in pregnancy

Petersson, Christine ; Hedges, Spencer ; Stenqvist, Karin ; Sandberg, Torsten ; Connell, Hugh LU and Svanborg, Catharina LU (1994) In Kidney International 45(2). p.571-577
Abstract

This study examined the effect of pregnancy on the host response to acute pyelonephritis. Urine and serum samples were obtained at the time of diagnosis and after two weeks, from non-pregnant and pregnant women with acute pyelonephritis. The samples were analyzed for interleukin-6 (IL-6) and specific antibody activity to antigens extracted from the Escherichia coli strain infecting each patient. The host response to infection was further quantitated as fever, C-reactive protein, and renal concentrating capacity. Acute pyelonephritis in non-pregnant and pregnant women was accompanied by a significant serum and urine antibody response. The serum antibody response was significantly lower in the pregnant group. The IL-6 levels in serum and... (More)

This study examined the effect of pregnancy on the host response to acute pyelonephritis. Urine and serum samples were obtained at the time of diagnosis and after two weeks, from non-pregnant and pregnant women with acute pyelonephritis. The samples were analyzed for interleukin-6 (IL-6) and specific antibody activity to antigens extracted from the Escherichia coli strain infecting each patient. The host response to infection was further quantitated as fever, C-reactive protein, and renal concentrating capacity. Acute pyelonephritis in non-pregnant and pregnant women was accompanied by a significant serum and urine antibody response. The serum antibody response was significantly lower in the pregnant group. The IL-6 levels in serum and urine at diagnosis were significantly higher in the non-pregnant compared to the pregnant women. These results demonstrate that the immunosuppression of pregnancy includes the mucosal IL-6 and specific antibody responses to acute pyelonephritis caused by E. coli.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Kidney International
volume
45
issue
2
pages
571 - 577
publisher
Nature Publishing Group
external identifiers
  • scopus:0027957242
  • pmid:8164447
ISSN
0085-2538
DOI
10.1038/ki.1994.74
language
English
LU publication?
yes
id
c0658415-d2a5-48cd-9b67-2e0a37c2edb1
date added to LUP
2019-06-19 14:06:16
date last changed
2020-01-13 02:03:31
@article{c0658415-d2a5-48cd-9b67-2e0a37c2edb1,
  abstract     = {<p>This study examined the effect of pregnancy on the host response to acute pyelonephritis. Urine and serum samples were obtained at the time of diagnosis and after two weeks, from non-pregnant and pregnant women with acute pyelonephritis. The samples were analyzed for interleukin-6 (IL-6) and specific antibody activity to antigens extracted from the Escherichia coli strain infecting each patient. The host response to infection was further quantitated as fever, C-reactive protein, and renal concentrating capacity. Acute pyelonephritis in non-pregnant and pregnant women was accompanied by a significant serum and urine antibody response. The serum antibody response was significantly lower in the pregnant group. The IL-6 levels in serum and urine at diagnosis were significantly higher in the non-pregnant compared to the pregnant women. These results demonstrate that the immunosuppression of pregnancy includes the mucosal IL-6 and specific antibody responses to acute pyelonephritis caused by E. coli.</p>},
  author       = {Petersson, Christine and Hedges, Spencer and Stenqvist, Karin and Sandberg, Torsten and Connell, Hugh and Svanborg, Catharina},
  issn         = {0085-2538},
  language     = {eng},
  number       = {2},
  pages        = {571--577},
  publisher    = {Nature Publishing Group},
  series       = {Kidney International},
  title        = {Suppressed antibody and interleukin-6 responses to acute pyelonephritis in pregnancy},
  url          = {http://dx.doi.org/10.1038/ki.1994.74},
  doi          = {10.1038/ki.1994.74},
  volume       = {45},
  year         = {1994},
}