Ethical issues raised by whole genome sequencing
(2014) In Best Practice and Research in Clinical Gastroenterology 28(2). p.79-269- Abstract
While there is ongoing discussion about the details of implementation of whole genome sequencing (WGS) and whole exome sequencing (WES), there appears to be a consensus amongst geneticists that the widespread use of these approaches is not only inevitable, but will also be beneficial [1]. However, at the present time, we are unable to anticipate the full range of uses, consequences and impact of implementing WGS and WES. Nevertheless, the already known ethical issues, both in research and in clinical practice are diverse and complex and should be addressed properly presently. Herein, we discuss the ethical aspects of WGS and WES by particularly focussing on three overlapping themes: (1) informed consent, (2) data handling, and (3) the... (More)
While there is ongoing discussion about the details of implementation of whole genome sequencing (WGS) and whole exome sequencing (WES), there appears to be a consensus amongst geneticists that the widespread use of these approaches is not only inevitable, but will also be beneficial [1]. However, at the present time, we are unable to anticipate the full range of uses, consequences and impact of implementing WGS and WES. Nevertheless, the already known ethical issues, both in research and in clinical practice are diverse and complex and should be addressed properly presently. Herein, we discuss the ethical aspects of WGS and WES by particularly focussing on three overlapping themes: (1) informed consent, (2) data handling, and (3) the return of results.
(Less)
- author
- Pinxten, Wim and Howard, Heidi Carmen LU
- publishing date
- 2014-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Databases, Genetic, Exome, Genome, Human, Genomics/ethics, Humans, Informed Consent/ethics, Sequence Analysis, DNA, Statistics as Topic
- in
- Best Practice and Research in Clinical Gastroenterology
- volume
- 28
- issue
- 2
- pages
- 11 pages
- publisher
- Baillière Tindall
- external identifiers
-
- scopus:84899839648
- pmid:24810188
- ISSN
- 1532-1916
- DOI
- 10.1016/j.bpg.2014.02.004
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2014 Elsevier Ltd. All rights reserved.
- id
- c06c269d-b856-406c-94c7-da42b02abc99
- date added to LUP
- 2021-11-01 10:24:47
- date last changed
- 2024-11-17 13:13:33
@article{c06c269d-b856-406c-94c7-da42b02abc99,
abstract = {{<p>While there is ongoing discussion about the details of implementation of whole genome sequencing (WGS) and whole exome sequencing (WES), there appears to be a consensus amongst geneticists that the widespread use of these approaches is not only inevitable, but will also be beneficial [1]. However, at the present time, we are unable to anticipate the full range of uses, consequences and impact of implementing WGS and WES. Nevertheless, the already known ethical issues, both in research and in clinical practice are diverse and complex and should be addressed properly presently. Herein, we discuss the ethical aspects of WGS and WES by particularly focussing on three overlapping themes: (1) informed consent, (2) data handling, and (3) the return of results. </p>}},
author = {{Pinxten, Wim and Howard, Heidi Carmen}},
issn = {{1532-1916}},
keywords = {{Databases, Genetic; Exome; Genome, Human; Genomics/ethics; Humans; Informed Consent/ethics; Sequence Analysis, DNA; Statistics as Topic}},
language = {{eng}},
number = {{2}},
pages = {{79--269}},
publisher = {{Baillière Tindall}},
series = {{Best Practice and Research in Clinical Gastroenterology}},
title = {{Ethical issues raised by whole genome sequencing}},
url = {{http://dx.doi.org/10.1016/j.bpg.2014.02.004}},
doi = {{10.1016/j.bpg.2014.02.004}},
volume = {{28}},
year = {{2014}},
}