The genetic contribution to hand osteoarthritis
Magnusson, K. LU ; Turkiewicz, A. LU ; Haugen, I. K. and Englund, M. LU
(2022)
In Osteoarthritis and Cartilage
30(10).
p.1385-1389
- Abstract
Objective: To estimate the genetic contribution to doctor-diagnosed hand osteoarthritis (OA). Methods: Using data from the Swedish Twin Registry and National Patient Register, we conducted a 20-year population-based longitudinal cohort study including 59,970 twins aged 35 years or older. We studied inpatient and outpatient doctor-diagnosed hand OA using ICD-10 codes from 1997 until 2016, including both the distal/proximal interphalangeal (DIP/PIP) joints and/or the first carpometacarpal (CMC-1) joints. We calculated intra-pair correlation, estimated the heritability (i.e., the percentage variation in hand OA that can be explained by genetic factors) as well as a genetic risk. Results: Among 59,970 included persons, 936 had a hand OA... (More)
Objective: To estimate the genetic contribution to doctor-diagnosed hand osteoarthritis (OA). Methods: Using data from the Swedish Twin Registry and National Patient Register, we conducted a 20-year population-based longitudinal cohort study including 59,970 twins aged 35 years or older. We studied inpatient and outpatient doctor-diagnosed hand OA using ICD-10 codes from 1997 until 2016, including both the distal/proximal interphalangeal (DIP/PIP) joints and/or the first carpometacarpal (CMC-1) joints. We calculated intra-pair correlation, estimated the heritability (i.e., the percentage variation in hand OA that can be explained by genetic factors) as well as a genetic risk. Results: Among 59,970 included persons, 936 had a hand OA diagnosis registered during the study period. The heritabilities of hand OA (any joint), CMC-1 OA and DIP/PIP OA were ∼87%, 86% and 48%, respectively, yet the two latter should be interpreted with care due to low numbers. Hand OA in any joint in both twins in a pair occurred more frequently in identical twins (54/554 = 9.7%, intra-pair correlation = 0.54, 95% CI = 0.44–0.63) than in fraternal twins (18/1,246 = 1.4%, intra-pair correlation = 0.10, 95% CI = −0.01–0.22). Identical twins who were diagnosed with hand OA in any joint had a far higher risk than fraternal twins with hand OA to also have their co-twin diagnosed with hand OA in any joint (Hazard Ratio = 6.98, 95% CI = 3.08–15.45). Conclusion: The genetic contribution to hand OA is high and likely varying between 48% and 87%. Potential differential heritability by hand OA phenotypes should be further explored.
(Less)
- author
- Magnusson, K.
LU
; Turkiewicz, A.
LU
; Haugen, I. K.
and Englund, M.
LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Epidemiology, Genetics, Hand OA
- in
- Osteoarthritis and Cartilage
- volume
- 30
- issue
- 10
- pages
- 1385 - 1389
- publisher
- Elsevier
- external identifiers
-
- scopus:85135841086
- pmid:35843480
- ISSN
- 1063-4584
- DOI
- 10.1016/j.joca.2022.06.011
- language
- English
- LU publication?
- yes
- id
- c07e90ba-8731-4e5c-8795-426c0ab4a9b8
- date added to LUP
- 2022-09-19 11:49:41
- date last changed
- 2024-06-13 15:52:22
@article{c07e90ba-8731-4e5c-8795-426c0ab4a9b8,
abstract = {{<p>Objective: To estimate the genetic contribution to doctor-diagnosed hand osteoarthritis (OA). Methods: Using data from the Swedish Twin Registry and National Patient Register, we conducted a 20-year population-based longitudinal cohort study including 59,970 twins aged 35 years or older. We studied inpatient and outpatient doctor-diagnosed hand OA using ICD-10 codes from 1997 until 2016, including both the distal/proximal interphalangeal (DIP/PIP) joints and/or the first carpometacarpal (CMC-1) joints. We calculated intra-pair correlation, estimated the heritability (i.e., the percentage variation in hand OA that can be explained by genetic factors) as well as a genetic risk. Results: Among 59,970 included persons, 936 had a hand OA diagnosis registered during the study period. The heritabilities of hand OA (any joint), CMC-1 OA and DIP/PIP OA were ∼87%, 86% and 48%, respectively, yet the two latter should be interpreted with care due to low numbers. Hand OA in any joint in both twins in a pair occurred more frequently in identical twins (54/554 = 9.7%, intra-pair correlation = 0.54, 95% CI = 0.44–0.63) than in fraternal twins (18/1,246 = 1.4%, intra-pair correlation = 0.10, 95% CI = −0.01–0.22). Identical twins who were diagnosed with hand OA in any joint had a far higher risk than fraternal twins with hand OA to also have their co-twin diagnosed with hand OA in any joint (Hazard Ratio = 6.98, 95% CI = 3.08–15.45). Conclusion: The genetic contribution to hand OA is high and likely varying between 48% and 87%. Potential differential heritability by hand OA phenotypes should be further explored.</p>}},
author = {{Magnusson, K. and Turkiewicz, A. and Haugen, I. K. and Englund, M.}},
issn = {{1063-4584}},
keywords = {{Epidemiology; Genetics; Hand OA}},
language = {{eng}},
number = {{10}},
pages = {{1385--1389}},
publisher = {{Elsevier}},
series = {{Osteoarthritis and Cartilage}},
title = {{The genetic contribution to hand osteoarthritis}},
url = {{http://dx.doi.org/10.1016/j.joca.2022.06.011}},
doi = {{10.1016/j.joca.2022.06.011}},
volume = {{30}},
year = {{2022}},
}