Emerging role of microRNAs as regulators of protein kinase C substrate MARCKS and MARCKSL1 in cancer
(2024) In Experimental Cell Research 434(2).- Abstract
MicroRNAs (miRNAs) have emerged as pivotal regulators of gene expression, playing essential roles in diverse cellular processes, including the development and progression of cancer. Among the numerous proteins influenced by miRNAs, the MARCKS/MARCKSL1 protein, a key regulator of cellular cytoskeletal dynamics and membrane-cytosol communication, has garnered significant attention due to its multifaceted involvement in various cancer-related processes, including cell migration, invasion, metastasis, and drug resistance. Motivated by the encouraging early clinical success of peptides targeting MARCKS in several pathological conditions, this review article delves into the intricate interplay between miRNAs and the MARCKS protein in cancer.... (More)
MicroRNAs (miRNAs) have emerged as pivotal regulators of gene expression, playing essential roles in diverse cellular processes, including the development and progression of cancer. Among the numerous proteins influenced by miRNAs, the MARCKS/MARCKSL1 protein, a key regulator of cellular cytoskeletal dynamics and membrane-cytosol communication, has garnered significant attention due to its multifaceted involvement in various cancer-related processes, including cell migration, invasion, metastasis, and drug resistance. Motivated by the encouraging early clinical success of peptides targeting MARCKS in several pathological conditions, this review article delves into the intricate interplay between miRNAs and the MARCKS protein in cancer. Herein, we have highlighted the latest findings on specific miRNAs that modulate MARCKS/MARCKSL1 expression, providing a comprehensive overview of their roles in different cancer types. We have underscored the need for in-depth investigations into the therapeutic feasibility of targeting the miRNA-MARCKS axis in cancer, taking cues from the successes witnessed in related fields. Unlocking the full potential of miRNA-mediated MARCKS regulation could pave the way for innovative and effective therapeutic interventions against various cancer types.
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- author
- Yadav, Vikas LU ; Jena, Manoj Kumar ; Parashar, Gaurav ; Parashar, Nidarshana Chaturvedi ; Joshi, Hemant ; Ramniwas, Seema and Tuli, Hardeep Singh
- organization
- publishing date
- 2024-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Drug resistance, MARCKS, Metastasis, microRNA, Protein kinase C, Targeted therapy
- in
- Experimental Cell Research
- volume
- 434
- issue
- 2
- article number
- 113891
- publisher
- Academic Press
- external identifiers
-
- pmid:38104645
- scopus:85180559850
- ISSN
- 0014-4827
- DOI
- 10.1016/j.yexcr.2023.113891
- language
- English
- LU publication?
- yes
- id
- c08853f7-ff68-4436-88d0-f5bfa8947b2b
- date added to LUP
- 2024-02-09 15:40:37
- date last changed
- 2024-04-23 16:07:18
@article{c08853f7-ff68-4436-88d0-f5bfa8947b2b,
abstract = {{<p>MicroRNAs (miRNAs) have emerged as pivotal regulators of gene expression, playing essential roles in diverse cellular processes, including the development and progression of cancer. Among the numerous proteins influenced by miRNAs, the MARCKS/MARCKSL1 protein, a key regulator of cellular cytoskeletal dynamics and membrane-cytosol communication, has garnered significant attention due to its multifaceted involvement in various cancer-related processes, including cell migration, invasion, metastasis, and drug resistance. Motivated by the encouraging early clinical success of peptides targeting MARCKS in several pathological conditions, this review article delves into the intricate interplay between miRNAs and the MARCKS protein in cancer. Herein, we have highlighted the latest findings on specific miRNAs that modulate MARCKS/MARCKSL1 expression, providing a comprehensive overview of their roles in different cancer types. We have underscored the need for in-depth investigations into the therapeutic feasibility of targeting the miRNA-MARCKS axis in cancer, taking cues from the successes witnessed in related fields. Unlocking the full potential of miRNA-mediated MARCKS regulation could pave the way for innovative and effective therapeutic interventions against various cancer types.</p>}},
author = {{Yadav, Vikas and Jena, Manoj Kumar and Parashar, Gaurav and Parashar, Nidarshana Chaturvedi and Joshi, Hemant and Ramniwas, Seema and Tuli, Hardeep Singh}},
issn = {{0014-4827}},
keywords = {{Drug resistance; MARCKS; Metastasis; microRNA; Protein kinase C; Targeted therapy}},
language = {{eng}},
number = {{2}},
publisher = {{Academic Press}},
series = {{Experimental Cell Research}},
title = {{Emerging role of microRNAs as regulators of protein kinase C substrate MARCKS and MARCKSL1 in cancer}},
url = {{http://dx.doi.org/10.1016/j.yexcr.2023.113891}},
doi = {{10.1016/j.yexcr.2023.113891}},
volume = {{434}},
year = {{2024}},
}