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Complications and Economic Burden of Surgery in Chronic Rhinosinusitis With Nasal Polyps : An Observational Cohort Study Using Swedish Register Data

Olsson, Petter ; Abé, Christoph ; Wolf, Maija ; Lilja, Mathias ; Maio-Twofoot, Tina ; Sunnergren, Ola and Sahlstrand-Johnson, Pernilla LU (2025) In Clinical Otolaryngology 50(6). p.1061-1070
Abstract

Introduction: There is a lack of comprehensive data on complications following sinus surgery (SS) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to estimate the prevalence of SS-related complications in CRSwNP patients and examine patient characteristics, predictors of revision surgery, healthcare use, and associated costs using secondary care data from Swedish registers. Methods: This observational cohort study used Swedish administrative register data to report patient characteristics and estimate the prevalence and incidence of SS-related complications among CRSwNP patients. Healthcare resource use (HCRU) and associated costs, the probability of and predictors for revision surgery were assessed.... (More)

Introduction: There is a lack of comprehensive data on complications following sinus surgery (SS) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to estimate the prevalence of SS-related complications in CRSwNP patients and examine patient characteristics, predictors of revision surgery, healthcare use, and associated costs using secondary care data from Swedish registers. Methods: This observational cohort study used Swedish administrative register data to report patient characteristics and estimate the prevalence and incidence of SS-related complications among CRSwNP patients. Healthcare resource use (HCRU) and associated costs, the probability of and predictors for revision surgery were assessed. Results: Out of 9178 CRSwNP patients who underwent SS, 8.5% experienced complications to SS. Asthma was the most frequently observed comorbidity. The probability of revision surgery within 4 years was 12%. Factors such as younger age at index, complications to first surgery, earlier index year, and comorbid asthma were significant predictors for future surgery. Within 4 years of follow-up, patients undergoing SS showed more HCRU and higher related costs compared to matched general population controls (€13 865 vs. €7088 per person; p < 0.001). Asthma comorbidity, the occurrence of complications, and undergone revision surgery were associated with higher costs. Conclusion: Overall, this study provides valuable clinical insights into patient characteristics, complications to SS, resource use, and factors related to revision surgery in patients with CRSwNP.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
asthma, chronic rhinosinusitis, nasal polyps, sinus surgery
in
Clinical Otolaryngology
volume
50
issue
6
pages
10 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:40754756
  • scopus:105012367677
ISSN
1749-4478
DOI
10.1111/coa.70009
language
English
LU publication?
yes
id
c094ae72-0ba3-4b8b-a0c1-ae3797f44e83
date added to LUP
2026-01-27 10:27:31
date last changed
2026-01-28 03:00:11
@article{c094ae72-0ba3-4b8b-a0c1-ae3797f44e83,
  abstract     = {{<p>Introduction: There is a lack of comprehensive data on complications following sinus surgery (SS) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to estimate the prevalence of SS-related complications in CRSwNP patients and examine patient characteristics, predictors of revision surgery, healthcare use, and associated costs using secondary care data from Swedish registers. Methods: This observational cohort study used Swedish administrative register data to report patient characteristics and estimate the prevalence and incidence of SS-related complications among CRSwNP patients. Healthcare resource use (HCRU) and associated costs, the probability of and predictors for revision surgery were assessed. Results: Out of 9178 CRSwNP patients who underwent SS, 8.5% experienced complications to SS. Asthma was the most frequently observed comorbidity. The probability of revision surgery within 4 years was 12%. Factors such as younger age at index, complications to first surgery, earlier index year, and comorbid asthma were significant predictors for future surgery. Within 4 years of follow-up, patients undergoing SS showed more HCRU and higher related costs compared to matched general population controls (€13 865 vs. €7088 per person; p &lt; 0.001). Asthma comorbidity, the occurrence of complications, and undergone revision surgery were associated with higher costs. Conclusion: Overall, this study provides valuable clinical insights into patient characteristics, complications to SS, resource use, and factors related to revision surgery in patients with CRSwNP.</p>}},
  author       = {{Olsson, Petter and Abé, Christoph and Wolf, Maija and Lilja, Mathias and Maio-Twofoot, Tina and Sunnergren, Ola and Sahlstrand-Johnson, Pernilla}},
  issn         = {{1749-4478}},
  keywords     = {{asthma; chronic rhinosinusitis; nasal polyps; sinus surgery}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1061--1070}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Clinical Otolaryngology}},
  title        = {{Complications and Economic Burden of Surgery in Chronic Rhinosinusitis With Nasal Polyps : An Observational Cohort Study Using Swedish Register Data}},
  url          = {{http://dx.doi.org/10.1111/coa.70009}},
  doi          = {{10.1111/coa.70009}},
  volume       = {{50}},
  year         = {{2025}},
}