Depression in type 1 diabetes was associated with high levels of circulating galectin-3
FÜRST MELIN, EVA LU ; Dereke, Jonatan LU
; Thunander, Maria
LU
and Hillman, Magnus
LU
(2018)
In Endocrine Connections
7(6).
p.919-928
- Abstract
- Objective: Neuroinflammatory responses are implicated in depression. The aim was to explore whether depression in patients with type 1 diabetes (T1D) was associated with high circulating galectin-3, controlling for metabolic variables, s-creatinine, life style factors, medication, and cardiovascular complications.
Design: Cross-sectional.
Methods: Participants were T1D patients (n=283, 56% men, age 18-59 years, diabetes duration ≥1 year). Depression was assessed by Hospital Anxiety and Depression Scale-depression subscale. Blood samples, anthropometrics and blood pressure were collected, supplemented with data from medical records and the Swedish National Diabetes Registry. Galectin-3 ≥2.562 µg/l, corresponding to the... (More) - Objective: Neuroinflammatory responses are implicated in depression. The aim was to explore whether depression in patients with type 1 diabetes (T1D) was associated with high circulating galectin-3, controlling for metabolic variables, s-creatinine, life style factors, medication, and cardiovascular complications.
Design: Cross-sectional.
Methods: Participants were T1D patients (n=283, 56% men, age 18-59 years, diabetes duration ≥1 year). Depression was assessed by Hospital Anxiety and Depression Scale-depression subscale. Blood samples, anthropometrics and blood pressure were collected, supplemented with data from medical records and the Swedish National Diabetes Registry. Galectin-3 ≥2.562 µg/l, corresponding to the 85th percentile, was defined as high galectin-3.
Results: Median (quartile1, quartile3) galectin-3 (µg/l) was 1.3 (0.8, 2.9) for the 30 depressed patients, and 0.9 (0.5, 1.6) for the 253 non-depressed, P = 0.009. Depression was associated with high galectin-3 in all the 283 patients (Adjusted odds ratio (AOR) 3.5), in the 161 men (AOR 3.4), and in the 122 women (AOR 3.9). HbA1c, s-lipids, s-creatinine, blood pressure, obesity, smoking, physical inactivity, cardiovascular complications, and drugs (antihypertensive, lipid lowering, oral antidiabetic drugs, and antidepressants) were not associated with high galectin-3.
Conclusions: This is the first study to show an association between depression and galectin-3. Depression was the only explored parameter associated with high circulating galectin-3 levels in 283 T1D patients. High galectin-3 levels might contribute to the increased risk for Alzheimer's disease, cardiovascular and all-cause mortality observed in persons with depression. Potentially, in the future, treatment targeting galactin-3 might improve the prognosis for patients with high galectin-3 levels. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c097f3a3-31a7-4b21-a607-376001f5ede3
- author
- FÜRST MELIN, EVA
LU
; Dereke, Jonatan
LU
; Thunander, Maria
LU
and Hillman, Magnus
LU
- organization
- publishing date
- 2018-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Endocrine Connections
- volume
- 7
- issue
- 6
- pages
- 10 pages
- publisher
- BioScientifica
- external identifiers
-
- pmid:29760188
- scopus:85049651599
- ISSN
- 2049-3614
- DOI
- 10.1530/EC-18-0108
- language
- English
- LU publication?
- yes
- id
- c097f3a3-31a7-4b21-a607-376001f5ede3
- date added to LUP
- 2018-05-24 13:21:21
- date last changed
- 2024-02-13 20:45:09
@article{c097f3a3-31a7-4b21-a607-376001f5ede3,
abstract = {{Objective: Neuroinflammatory responses are implicated in depression. The aim was to explore whether depression in patients with type 1 diabetes (T1D) was associated with high circulating galectin-3, controlling for metabolic variables, s-creatinine, life style factors, medication, and cardiovascular complications.<br/><br/>Design: Cross-sectional.<br/><br/>Methods: Participants were T1D patients (n=283, 56% men, age 18-59 years, diabetes duration ≥1 year). Depression was assessed by Hospital Anxiety and Depression Scale-depression subscale. Blood samples, anthropometrics and blood pressure were collected, supplemented with data from medical records and the Swedish National Diabetes Registry. Galectin-3 ≥2.562 µg/l, corresponding to the 85th percentile, was defined as high galectin-3.<br/><br/>Results: Median (quartile1, quartile3) galectin-3 (µg/l) was 1.3 (0.8, 2.9) for the 30 depressed patients, and 0.9 (0.5, 1.6) for the 253 non-depressed, P = 0.009. Depression was associated with high galectin-3 in all the 283 patients (Adjusted odds ratio (AOR) 3.5), in the 161 men (AOR 3.4), and in the 122 women (AOR 3.9). HbA1c, s-lipids, s-creatinine, blood pressure, obesity, smoking, physical inactivity, cardiovascular complications, and drugs (antihypertensive, lipid lowering, oral antidiabetic drugs, and antidepressants) were not associated with high galectin-3.<br/><br/>Conclusions: This is the first study to show an association between depression and galectin-3. Depression was the only explored parameter associated with high circulating galectin-3 levels in 283 T1D patients. High galectin-3 levels might contribute to the increased risk for Alzheimer's disease, cardiovascular and all-cause mortality observed in persons with depression. Potentially, in the future, treatment targeting galactin-3 might improve the prognosis for patients with high galectin-3 levels.}},
author = {{FÜRST MELIN, EVA and Dereke, Jonatan and Thunander, Maria and Hillman, Magnus}},
issn = {{2049-3614}},
language = {{eng}},
month = {{06}},
number = {{6}},
pages = {{919--928}},
publisher = {{BioScientifica}},
series = {{Endocrine Connections}},
title = {{Depression in type 1 diabetes was associated with high levels of circulating galectin-3}},
url = {{http://dx.doi.org/10.1530/EC-18-0108}},
doi = {{10.1530/EC-18-0108}},
volume = {{7}},
year = {{2018}},
}