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An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment

Tekpli, Xavier ; Lien, Tonje ; Røssevold, Andreas Hagen ; Nebdal, Daniel ; Borgen, Elin ; Ohnstad, Hege Oma ; Kyte, Jon Amund ; Vallon-Christersson, Johan LU orcid ; Fongaard, Marie and Due, Eldri Undlien , et al. (2019) In Nature Communications 10(1).
Abstract

How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. The intermediate immune infiltration cluster (Cluster B) is associated with a worse prognosis independently of known clinicopathological features. Furthermore, immune clusters are associated with response to neoadjuvant chemotherapy. In silico dissection of the immune contexture of the clusters identified Cluster A as immune cold, Cluster C as immune hot while Cluster B has a pro-tumorigenic immune infiltration. Through phenotypical analysis, we find epithelial mesenchymal transition and... (More)

How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. The intermediate immune infiltration cluster (Cluster B) is associated with a worse prognosis independently of known clinicopathological features. Furthermore, immune clusters are associated with response to neoadjuvant chemotherapy. In silico dissection of the immune contexture of the clusters identified Cluster A as immune cold, Cluster C as immune hot while Cluster B has a pro-tumorigenic immune infiltration. Through phenotypical analysis, we find epithelial mesenchymal transition and proliferation associated with the immune clusters and mutually exclusive in breast cancers. Here, we describe immune clusters which improve the prognostic accuracy of immune contexture in breast cancer. Our discovery of a novel independent prognostic factor in breast cancer highlights a correlation between tumor phenotype and immune contexture.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
10
issue
1
article number
5499
publisher
Nature Publishing Group
external identifiers
  • scopus:85075930228
  • pmid:31796750
ISSN
2041-1723
DOI
10.1038/s41467-019-13329-5
language
English
LU publication?
yes
id
c0c58bba-96c8-4eb4-a0aa-8a6b569b3e82
date added to LUP
2022-03-29 11:57:24
date last changed
2024-06-06 19:03:42
@article{c0c58bba-96c8-4eb4-a0aa-8a6b569b3e82,
  abstract     = {{<p>How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. The intermediate immune infiltration cluster (Cluster B) is associated with a worse prognosis independently of known clinicopathological features. Furthermore, immune clusters are associated with response to neoadjuvant chemotherapy. In silico dissection of the immune contexture of the clusters identified Cluster A as immune cold, Cluster C as immune hot while Cluster B has a pro-tumorigenic immune infiltration. Through phenotypical analysis, we find epithelial mesenchymal transition and proliferation associated with the immune clusters and mutually exclusive in breast cancers. Here, we describe immune clusters which improve the prognostic accuracy of immune contexture in breast cancer. Our discovery of a novel independent prognostic factor in breast cancer highlights a correlation between tumor phenotype and immune contexture.</p>}},
  author       = {{Tekpli, Xavier and Lien, Tonje and Røssevold, Andreas Hagen and Nebdal, Daniel and Borgen, Elin and Ohnstad, Hege Oma and Kyte, Jon Amund and Vallon-Christersson, Johan and Fongaard, Marie and Due, Eldri Undlien and Svartdal, Lisa Gregusson and Sveli, My Anh Tu and Garred, Øystein and Børresen-Dale, Anne Lise and Schlichting, Ellen and Sauer, Torill and Geisler, Jürgen and Hofvind, Solveig and Bathen, Tone F. and Engebråten, Olav and Geitvik, Gry Aarum and Langerød, Anita and Kåresen, Rolf and Mælandsmo, Gunhild Mari and Lingjærde, Ole Christian and Skjerven, Helle Kristine and Park, Daehoon and Fritzman, Britt and Frigessi, Arnoldo and Sahlberg, Kristine Kleivi and Sørlie, Therese and Russnes, Hege G. and Naume, Bjørn and Kristensen, Vessela N.}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment}},
  url          = {{http://dx.doi.org/10.1038/s41467-019-13329-5}},
  doi          = {{10.1038/s41467-019-13329-5}},
  volume       = {{10}},
  year         = {{2019}},
}