Lateral pressure profiles in cholesterol-DPPC bilayers
(2005) In European Biophysics Journal 35(1). p.79-88- Abstract
- By means of atomistic molecular dynamics simulations, we study cholesterol-DPPC (dipalmitoyl phosphatidylcholine) bilayers of different composition, from pure DPPC bilayers to a 1:1 mixture of DPPC and cholesterol. The lateral pressure profiles through the bilayers are computed and separated into contributions from the different components. We find that the pressure inside the bilayer changes qualitatively for cholesterol concentrations of about 20% or higher. The pressure profile in the inside of the bilayer then turns from a rather flat shape into an alternating sequence of regions with large positive and negative lateral pressure. The changes in the lateral pressure profile are so characteristic that specific interaction between... (More)
- By means of atomistic molecular dynamics simulations, we study cholesterol-DPPC (dipalmitoyl phosphatidylcholine) bilayers of different composition, from pure DPPC bilayers to a 1:1 mixture of DPPC and cholesterol. The lateral pressure profiles through the bilayers are computed and separated into contributions from the different components. We find that the pressure inside the bilayer changes qualitatively for cholesterol concentrations of about 20% or higher. The pressure profile in the inside of the bilayer then turns from a rather flat shape into an alternating sequence of regions with large positive and negative lateral pressure. The changes in the lateral pressure profile are so characteristic that specific interaction between cholesterol and molecules such as membrane proteins mediated solely via the lateral pressure profile might become possible. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/213226
- author
- Patra, Michael LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ion channel regulation, lipid bilayer, energetics, thermodynamics
- in
- European Biophysics Journal
- volume
- 35
- issue
- 1
- pages
- 79 - 88
- publisher
- Springer
- external identifiers
-
- wos:000233392200007
- pmid:16205919
- scopus:27944504707
- pmid:16205919
- ISSN
- 0175-7571
- DOI
- 10.1007/s00249-005-0011-0
- language
- English
- LU publication?
- yes
- id
- c0cc0112-ed5e-457f-852d-a97bc4d22871 (old id 213226)
- date added to LUP
- 2016-04-01 15:38:27
- date last changed
- 2022-01-28 06:22:01
@article{c0cc0112-ed5e-457f-852d-a97bc4d22871,
abstract = {{By means of atomistic molecular dynamics simulations, we study cholesterol-DPPC (dipalmitoyl phosphatidylcholine) bilayers of different composition, from pure DPPC bilayers to a 1:1 mixture of DPPC and cholesterol. The lateral pressure profiles through the bilayers are computed and separated into contributions from the different components. We find that the pressure inside the bilayer changes qualitatively for cholesterol concentrations of about 20% or higher. The pressure profile in the inside of the bilayer then turns from a rather flat shape into an alternating sequence of regions with large positive and negative lateral pressure. The changes in the lateral pressure profile are so characteristic that specific interaction between cholesterol and molecules such as membrane proteins mediated solely via the lateral pressure profile might become possible.}},
author = {{Patra, Michael}},
issn = {{0175-7571}},
keywords = {{ion channel regulation; lipid bilayer; energetics; thermodynamics}},
language = {{eng}},
number = {{1}},
pages = {{79--88}},
publisher = {{Springer}},
series = {{European Biophysics Journal}},
title = {{Lateral pressure profiles in cholesterol-DPPC bilayers}},
url = {{http://dx.doi.org/10.1007/s00249-005-0011-0}},
doi = {{10.1007/s00249-005-0011-0}},
volume = {{35}},
year = {{2005}},
}