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PVL-positiva Staph aureus gav nekrotiserande pneumoni : Beskrivning av tre svära fall hos tidigare friska unga

Ek, Torben ; Andersson, Ola LU orcid ; Kasemo, Anna U. ; Wede, Mia LU and Nilsson, Peter A. (2007) In Läkartidningen 104(7). p.509-513
Abstract

We describe three cases of community-acquired pneumonia, in which the causative agent was methicillin sensitive S. Aureus positive for Panton-Valentine leukocidin (PVL). The patients were previously healthy children (2 weeks, 12 years and 15 years old). No epidemiologic connection existed, confirmed by spa-typing. Two cases were primary pneumonias with signs of necrosis, and the third case was a pleuropneumonia with empyema secondary to a hematogenous osteomyelitis. All had leukopenia in the acute phase, and the response to initial antibiotics was poor. Two patients needed ventilator treatment, one of them was rescued with extracorporeal membrane oxygenation. All patients survived. Prompt diagnosis and treatment with antibiotics that... (More)

We describe three cases of community-acquired pneumonia, in which the causative agent was methicillin sensitive S. Aureus positive for Panton-Valentine leukocidin (PVL). The patients were previously healthy children (2 weeks, 12 years and 15 years old). No epidemiologic connection existed, confirmed by spa-typing. Two cases were primary pneumonias with signs of necrosis, and the third case was a pleuropneumonia with empyema secondary to a hematogenous osteomyelitis. All had leukopenia in the acute phase, and the response to initial antibiotics was poor. Two patients needed ventilator treatment, one of them was rescued with extracorporeal membrane oxygenation. All patients survived. Prompt diagnosis and treatment with antibiotics that inhibit the PVL-exotoxin release (eg clindamycin or linezolide) is recommended. Two patients were treated with intravenous immunoglobulin (2 g/kg), which can be an option in severe cases.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Läkartidningen
volume
104
issue
7
pages
509 - 513
publisher
Swedish Medical Association
external identifiers
  • scopus:33847164019
  • pmid:17375682
ISSN
0023-7205
language
Swedish
LU publication?
no
id
c0ea8a08-14ff-4294-bc71-618c17566723
alternative location
http://www.lakartidningen.se/OldWebArticlePdf/6/6085/LKT0707s509_513.pdf
date added to LUP
2019-06-19 06:50:58
date last changed
2024-05-28 16:33:06
@article{c0ea8a08-14ff-4294-bc71-618c17566723,
  abstract     = {{<p>We describe three cases of community-acquired pneumonia, in which the causative agent was methicillin sensitive S. Aureus positive for Panton-Valentine leukocidin (PVL). The patients were previously healthy children (2 weeks, 12 years and 15 years old). No epidemiologic connection existed, confirmed by spa-typing. Two cases were primary pneumonias with signs of necrosis, and the third case was a pleuropneumonia with empyema secondary to a hematogenous osteomyelitis. All had leukopenia in the acute phase, and the response to initial antibiotics was poor. Two patients needed ventilator treatment, one of them was rescued with extracorporeal membrane oxygenation. All patients survived. Prompt diagnosis and treatment with antibiotics that inhibit the PVL-exotoxin release (eg clindamycin or linezolide) is recommended. Two patients were treated with intravenous immunoglobulin (2 g/kg), which can be an option in severe cases.</p>}},
  author       = {{Ek, Torben and Andersson, Ola and Kasemo, Anna U. and Wede, Mia and Nilsson, Peter A.}},
  issn         = {{0023-7205}},
  language     = {{swe}},
  month        = {{02}},
  number       = {{7}},
  pages        = {{509--513}},
  publisher    = {{Swedish Medical Association}},
  series       = {{Läkartidningen}},
  title        = {{PVL-positiva Staph aureus gav nekrotiserande pneumoni : Beskrivning av tre svära fall hos tidigare friska unga}},
  url          = {{http://www.lakartidningen.se/OldWebArticlePdf/6/6085/LKT0707s509_513.pdf}},
  volume       = {{104}},
  year         = {{2007}},
}