PVL-positiva Staph aureus gav nekrotiserande pneumoni : Beskrivning av tre svära fall hos tidigare friska unga
(2007) In Läkartidningen 104(7). p.509-513- Abstract
We describe three cases of community-acquired pneumonia, in which the causative agent was methicillin sensitive S. Aureus positive for Panton-Valentine leukocidin (PVL). The patients were previously healthy children (2 weeks, 12 years and 15 years old). No epidemiologic connection existed, confirmed by spa-typing. Two cases were primary pneumonias with signs of necrosis, and the third case was a pleuropneumonia with empyema secondary to a hematogenous osteomyelitis. All had leukopenia in the acute phase, and the response to initial antibiotics was poor. Two patients needed ventilator treatment, one of them was rescued with extracorporeal membrane oxygenation. All patients survived. Prompt diagnosis and treatment with antibiotics that... (More)
We describe three cases of community-acquired pneumonia, in which the causative agent was methicillin sensitive S. Aureus positive for Panton-Valentine leukocidin (PVL). The patients were previously healthy children (2 weeks, 12 years and 15 years old). No epidemiologic connection existed, confirmed by spa-typing. Two cases were primary pneumonias with signs of necrosis, and the third case was a pleuropneumonia with empyema secondary to a hematogenous osteomyelitis. All had leukopenia in the acute phase, and the response to initial antibiotics was poor. Two patients needed ventilator treatment, one of them was rescued with extracorporeal membrane oxygenation. All patients survived. Prompt diagnosis and treatment with antibiotics that inhibit the PVL-exotoxin release (eg clindamycin or linezolide) is recommended. Two patients were treated with intravenous immunoglobulin (2 g/kg), which can be an option in severe cases.
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- author
- Ek, Torben ; Andersson, Ola LU ; Kasemo, Anna U. ; Wede, Mia LU and Nilsson, Peter A.
- publishing date
- 2007-02-20
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Läkartidningen
- volume
- 104
- issue
- 7
- pages
- 509 - 513
- publisher
- Swedish Medical Association
- external identifiers
-
- scopus:33847164019
- pmid:17375682
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- no
- id
- c0ea8a08-14ff-4294-bc71-618c17566723
- alternative location
- http://www.lakartidningen.se/OldWebArticlePdf/6/6085/LKT0707s509_513.pdf
- date added to LUP
- 2019-06-19 06:50:58
- date last changed
- 2024-09-18 02:34:17
@article{c0ea8a08-14ff-4294-bc71-618c17566723, abstract = {{<p>We describe three cases of community-acquired pneumonia, in which the causative agent was methicillin sensitive S. Aureus positive for Panton-Valentine leukocidin (PVL). The patients were previously healthy children (2 weeks, 12 years and 15 years old). No epidemiologic connection existed, confirmed by spa-typing. Two cases were primary pneumonias with signs of necrosis, and the third case was a pleuropneumonia with empyema secondary to a hematogenous osteomyelitis. All had leukopenia in the acute phase, and the response to initial antibiotics was poor. Two patients needed ventilator treatment, one of them was rescued with extracorporeal membrane oxygenation. All patients survived. Prompt diagnosis and treatment with antibiotics that inhibit the PVL-exotoxin release (eg clindamycin or linezolide) is recommended. Two patients were treated with intravenous immunoglobulin (2 g/kg), which can be an option in severe cases.</p>}}, author = {{Ek, Torben and Andersson, Ola and Kasemo, Anna U. and Wede, Mia and Nilsson, Peter A.}}, issn = {{0023-7205}}, language = {{swe}}, month = {{02}}, number = {{7}}, pages = {{509--513}}, publisher = {{Swedish Medical Association}}, series = {{Läkartidningen}}, title = {{PVL-positiva Staph aureus gav nekrotiserande pneumoni : Beskrivning av tre svära fall hos tidigare friska unga}}, url = {{http://www.lakartidningen.se/OldWebArticlePdf/6/6085/LKT0707s509_513.pdf}}, volume = {{104}}, year = {{2007}}, }