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Long non-coding RNA in stem cell pluripotency and lineage commitment : functions and evolutionary conservation

Fico, Annalisa ; Fiorenzano, Alessandro LU ; Pascale, Emilia ; Patriarca, Eduardo Jorge and Minchiotti, Gabriella (2019) In Cellular and Molecular Life Sciences 76(8). p.1459-1471
Abstract

LncRNAs have recently emerged as new and fundamental transcriptional and post-transcriptional regulators acting at multiple levels of gene expression. Indeed, lncRNAs participate in a wide variety of stem cell and developmental processes, acting in cis and/or in trans in the nuclear and/or in the cytoplasmic compartments, and generating an intricate network of interactions with RNAs, enhancers, and chromatin-modifier complexes. Given the versatility of these molecules to operate in different subcellular compartments, via different modes of action and with different target specificity, the interest in this research field is rapidly growing. Here, we review recent progress in defining the functional role of lncRNAs in stem cell biology... (More)

LncRNAs have recently emerged as new and fundamental transcriptional and post-transcriptional regulators acting at multiple levels of gene expression. Indeed, lncRNAs participate in a wide variety of stem cell and developmental processes, acting in cis and/or in trans in the nuclear and/or in the cytoplasmic compartments, and generating an intricate network of interactions with RNAs, enhancers, and chromatin-modifier complexes. Given the versatility of these molecules to operate in different subcellular compartments, via different modes of action and with different target specificity, the interest in this research field is rapidly growing. Here, we review recent progress in defining the functional role of lncRNAs in stem cell biology with a specific focus on the underlying mechanisms. We also discuss recent findings on a new family of evolutionary conserved lncRNAs transcribed from ultraconserved elements, which show perfect conservation between human, mouse, and rat genomes, and that are emerging as new player in this complex scenario.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Embryonic stem cells, LncRNAs, T-UCEs, Ultraconserved elements
in
Cellular and Molecular Life Sciences
volume
76
issue
8
pages
1459 - 1471
publisher
Birkhäuser Verlag
external identifiers
  • scopus:85059508138
  • pmid:30607432
ISSN
1420-682X
DOI
10.1007/s00018-018-3000-z
language
English
LU publication?
yes
id
c138a868-f8f3-49ba-a55a-8da436075975
date added to LUP
2019-01-22 13:42:27
date last changed
2024-04-01 19:52:37
@article{c138a868-f8f3-49ba-a55a-8da436075975,
  abstract     = {{<p>LncRNAs have recently emerged as new and fundamental transcriptional and post-transcriptional regulators acting at multiple levels of gene expression. Indeed, lncRNAs participate in a wide variety of stem cell and developmental processes, acting in cis and/or in trans in the nuclear and/or in the cytoplasmic compartments, and generating an intricate network of interactions with RNAs, enhancers, and chromatin-modifier complexes. Given the versatility of these molecules to operate in different subcellular compartments, via different modes of action and with different target specificity, the interest in this research field is rapidly growing. Here, we review recent progress in defining the functional role of lncRNAs in stem cell biology with a specific focus on the underlying mechanisms. We also discuss recent findings on a new family of evolutionary conserved lncRNAs transcribed from ultraconserved elements, which show perfect conservation between human, mouse, and rat genomes, and that are emerging as new player in this complex scenario.</p>}},
  author       = {{Fico, Annalisa and Fiorenzano, Alessandro and Pascale, Emilia and Patriarca, Eduardo Jorge and Minchiotti, Gabriella}},
  issn         = {{1420-682X}},
  keywords     = {{Embryonic stem cells; LncRNAs; T-UCEs; Ultraconserved elements}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{8}},
  pages        = {{1459--1471}},
  publisher    = {{Birkhäuser Verlag}},
  series       = {{Cellular and Molecular Life Sciences}},
  title        = {{Long non-coding RNA in stem cell pluripotency and lineage commitment : functions and evolutionary conservation}},
  url          = {{http://dx.doi.org/10.1007/s00018-018-3000-z}},
  doi          = {{10.1007/s00018-018-3000-z}},
  volume       = {{76}},
  year         = {{2019}},
}