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A highly efficient and selective antitumor agent based on a glucoconjugated carbene platinum(ii) complex

Annunziata, Alfonso ; Cucciolito, Maria Elena ; Esposito, Roberto ; Imbimbo, Paola ; Petruk, Ganna LU orcid ; Ferraro, Giarita ; Pinto, Valerio ; Tuzi, Angela ; Monti, Daria Maria and Merlino, Antonello , et al. (2019) In Dalton Transactions 48(22). p.7794-7800
Abstract

New five-coordinate Pt(ii) complexes containing a glycosylated carbene fragment were synthesized. A member of this class shows very high in vitro cytotoxicity and an exceptional selectivity toward malignant cells. The complex lacking the sugary portion fails in the recognition of cancer cells. The results support the use of glycosylation in the design of carbene Pt-based anticancer agents.

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publishing date
type
Contribution to journal
publication status
published
in
Dalton Transactions
volume
48
issue
22
pages
7794 - 7800
publisher
Royal Society of Chemistry
external identifiers
  • scopus:85066834978
  • pmid:31069352
ISSN
1477-9226
DOI
10.1039/c9dt01614g
language
English
LU publication?
no
additional info
Publisher Copyright: © The Royal Society of Chemistry 2019.
id
c145d7fd-e7b0-4837-8d2e-05bad63b207a
date added to LUP
2025-01-21 15:40:50
date last changed
2025-04-30 02:02:06
@article{c145d7fd-e7b0-4837-8d2e-05bad63b207a,
  abstract     = {{<p>New five-coordinate Pt(ii) complexes containing a glycosylated carbene fragment were synthesized. A member of this class shows very high in vitro cytotoxicity and an exceptional selectivity toward malignant cells. The complex lacking the sugary portion fails in the recognition of cancer cells. The results support the use of glycosylation in the design of carbene Pt-based anticancer agents.</p>}},
  author       = {{Annunziata, Alfonso and Cucciolito, Maria Elena and Esposito, Roberto and Imbimbo, Paola and Petruk, Ganna and Ferraro, Giarita and Pinto, Valerio and Tuzi, Angela and Monti, Daria Maria and Merlino, Antonello and Ruffo, Francesco}},
  issn         = {{1477-9226}},
  language     = {{eng}},
  number       = {{22}},
  pages        = {{7794--7800}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Dalton Transactions}},
  title        = {{A highly efficient and selective antitumor agent based on a glucoconjugated carbene platinum(ii) complex}},
  url          = {{http://dx.doi.org/10.1039/c9dt01614g}},
  doi          = {{10.1039/c9dt01614g}},
  volume       = {{48}},
  year         = {{2019}},
}