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Resampling Strategies to Estimate Mean Concentrations from Low SNR In Vivo MR Spectra

Helms, Gunther LU ; Savic, Ivanka and Dechent, Peter (2007) In Proc. Intl. Soc. Mag. Reson. Med. 15.
Abstract
A resampling method for quantitative MRS is presented that retains absolute concentrations. Averaging the spectra from a subset improved the concentration
estimates via increased SNR. Using short-TE STEAM spectra from human thalamus, the influence of subset size was systematically studied and verified
against conventional bootstrap re-sampling. Even small subsets provided considerably better signal-to-noise ratio and reliability. The standard deviation or
confidence intervals can be derived by correcting the variance over all subset estimates for the inherent redundancy. Subsets of about half the group size are
recommended, because of their large number and the almost normal distribution of mean concentration estimates.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
MRS quantification resampling
in
Proc. Intl. Soc. Mag. Reson. Med.
volume
15
publisher
International Society for Magnetic Resonance in Medicine
ISSN
1524-6965
1524-6965
language
English
LU publication?
yes
id
c14fd670-5dfd-402a-9413-e16d08e97234
date added to LUP
2017-01-19 16:46:26
date last changed
2017-06-02 12:43:53
@inproceedings{c14fd670-5dfd-402a-9413-e16d08e97234,
  abstract     = {A resampling method for quantitative MRS is presented that retains absolute concentrations. Averaging the spectra from a subset improved the concentration<br/>estimates via increased SNR. Using short-TE STEAM spectra from human thalamus, the influence of subset size was systematically studied and verified<br/>against conventional bootstrap re-sampling. Even small subsets provided considerably better signal-to-noise ratio and reliability. The standard deviation or<br/>confidence intervals can be derived by correcting the variance over all subset estimates for the inherent redundancy. Subsets of about half the group size are<br/>recommended, because of their large number and the almost normal distribution of mean concentration estimates.},
  author       = {Helms, Gunther and Savic, Ivanka and Dechent, Peter},
  booktitle    = {Proc. Intl. Soc. Mag. Reson. Med.},
  issn         = {1524-6965},
  keyword      = {MRS quantification resampling},
  language     = {eng},
  publisher    = {International Society for Magnetic Resonance in Medicine},
  title        = {Resampling Strategies to Estimate Mean Concentrations from Low SNR In Vivo MR Spectra},
  volume       = {15},
  year         = {2007},
}