Association between human papillomavirus status and health-related quality of life in oropharyngeal and oral cavity cancer survivors
(2020) In Oral Oncology 109.- Abstract
Objectives: The human papillomavirus (HPV) is a risk factor for a subgroup of head and neck cancers (HNC). HPV-positive and HPV-negative HNC patients encompass heterogeneous groups regarding risk factors, sociodemographic and clinical characteristics, which may influence health-related quality of life (HRQL) differently. Since this has been sparsely studied, our study investigated the association between HPV status and HRQL in HNC survivors in Denmark. Materials and methods: This cross-sectional study included 179 recurrence-free oropharyngeal and oral cavity squamous cell carcinoma (OSCC) survivors. HRQL was assessed on the EORTC QLQ-C30 and QLQ-H&N35 questionnaires. Linear and logistic regression models were adjusted for... (More)
Objectives: The human papillomavirus (HPV) is a risk factor for a subgroup of head and neck cancers (HNC). HPV-positive and HPV-negative HNC patients encompass heterogeneous groups regarding risk factors, sociodemographic and clinical characteristics, which may influence health-related quality of life (HRQL) differently. Since this has been sparsely studied, our study investigated the association between HPV status and HRQL in HNC survivors in Denmark. Materials and methods: This cross-sectional study included 179 recurrence-free oropharyngeal and oral cavity squamous cell carcinoma (OSCC) survivors. HRQL was assessed on the EORTC QLQ-C30 and QLQ-H&N35 questionnaires. Linear and logistic regression models were adjusted for sociodemographic, clinical and lifestyle factors. Results: Most unadjusted results showed better HRQL among HPV-positive (n = 119) compared to HPV-negative (n = 60) OSCC survivors (average 18 months since diagnosis). After adjustments, the HPV-positive survivors reported higher role functioning (mean difference [MD] 9.2, 95% confidence interval [CI] 0.1 to –18.4), and fewer problems with speech (MD −9.0, 95% CI −18.0 to −0.1), sexuality (MD −21.9, 95% CI −38.0 to −5.9) and opening mouth (MD −13.7, 95% CI −26.6 to −0.8) compared to HPV-negative survivors. Conclusion: Our findings support that HPV-positive OSCC survivors experience better HRQL than HPV-negative survivors. However, results indicate that sociodemographic, clinical and lifestyle factors explain most of the association between HPV status and HRQL. Findings suggest increased focus on the HPV-negative OSCC survivors with deteriorated HRQL in rehabilitation programs and future research to investigate the long-term effects of treatment among HPV-positive OSCC survivors who may develop symptoms later in survivorship.
(Less)
- author
- Kjeldsted, Eva ; Dalton, Susanne Oksbjerg ; Frederiksen, Kirsten ; Andersen, Elo ; Nielsen, Anni Linnet ; Stafström, Martin LU and Kjaer, Trille Kristina
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Head and neck cancer, HPV, Human papillomavirus, Late effects, Quality of life
- in
- Oral Oncology
- volume
- 109
- article number
- 104918
- publisher
- Elsevier
- external identifiers
-
- pmid:32795908
- scopus:85089219310
- ISSN
- 1368-8375
- DOI
- 10.1016/j.oraloncology.2020.104918
- language
- English
- LU publication?
- yes
- id
- c1868e67-596e-41e6-8907-cfa978d76921
- date added to LUP
- 2020-08-17 12:14:02
- date last changed
- 2024-03-05 03:18:23
@article{c1868e67-596e-41e6-8907-cfa978d76921,
abstract = {{<p>Objectives: The human papillomavirus (HPV) is a risk factor for a subgroup of head and neck cancers (HNC). HPV-positive and HPV-negative HNC patients encompass heterogeneous groups regarding risk factors, sociodemographic and clinical characteristics, which may influence health-related quality of life (HRQL) differently. Since this has been sparsely studied, our study investigated the association between HPV status and HRQL in HNC survivors in Denmark. Materials and methods: This cross-sectional study included 179 recurrence-free oropharyngeal and oral cavity squamous cell carcinoma (OSCC) survivors. HRQL was assessed on the EORTC QLQ-C30 and QLQ-H&N35 questionnaires. Linear and logistic regression models were adjusted for sociodemographic, clinical and lifestyle factors. Results: Most unadjusted results showed better HRQL among HPV-positive (n = 119) compared to HPV-negative (n = 60) OSCC survivors (average 18 months since diagnosis). After adjustments, the HPV-positive survivors reported higher role functioning (mean difference [MD] 9.2, 95% confidence interval [CI] 0.1 to –18.4), and fewer problems with speech (MD −9.0, 95% CI −18.0 to −0.1), sexuality (MD −21.9, 95% CI −38.0 to −5.9) and opening mouth (MD −13.7, 95% CI −26.6 to −0.8) compared to HPV-negative survivors. Conclusion: Our findings support that HPV-positive OSCC survivors experience better HRQL than HPV-negative survivors. However, results indicate that sociodemographic, clinical and lifestyle factors explain most of the association between HPV status and HRQL. Findings suggest increased focus on the HPV-negative OSCC survivors with deteriorated HRQL in rehabilitation programs and future research to investigate the long-term effects of treatment among HPV-positive OSCC survivors who may develop symptoms later in survivorship.</p>}},
author = {{Kjeldsted, Eva and Dalton, Susanne Oksbjerg and Frederiksen, Kirsten and Andersen, Elo and Nielsen, Anni Linnet and Stafström, Martin and Kjaer, Trille Kristina}},
issn = {{1368-8375}},
keywords = {{Head and neck cancer; HPV; Human papillomavirus; Late effects; Quality of life}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Oral Oncology}},
title = {{Association between human papillomavirus status and health-related quality of life in oropharyngeal and oral cavity cancer survivors}},
url = {{http://dx.doi.org/10.1016/j.oraloncology.2020.104918}},
doi = {{10.1016/j.oraloncology.2020.104918}},
volume = {{109}},
year = {{2020}},
}