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Core-Shell Spheroidal Hydrogels Produced via Charge-Driven Interfacial Complexation

Calabrese, Vincenzo ; Califano, Davide ; da Silva, Marcelo A. ; Schmitt, Julien LU ; Bryant, Saffron J. ; Hossain, Kazi M. Zakir ; Percebom, Ana M. ; Pérez Gramatges, Aurora ; Scott, Janet L. and Edler, Karen J. LU orcid (2020) In ACS Applied Polymer Materials 2(3). p.1213-1221
Abstract

Through charge-driven interfacial complexation, we produced millimeter-sized spheroidal hydrogels (SH) with a core-shell structure allowing long-term stability in aqueous media. The SH were fabricated by extruding, dropwise, a cationic cellulose nanofibril (CCNF) dispersion into an oppositely charged poly(acrylic acid) (PAA) bath. The SH have a solid-like CCNF-PAA shell, acting as a semipermeable membrane, and a liquid-like CCNF suspension in the core. Swelling behavior of the SH was dependent on the osmotic pressure of the aging media. Swelling could be suppressed by increasing the ionic strength of the media as this enhanced interfibrillar interactions and thus strengthened the outer gel membrane. We further validated a potential... (More)

Through charge-driven interfacial complexation, we produced millimeter-sized spheroidal hydrogels (SH) with a core-shell structure allowing long-term stability in aqueous media. The SH were fabricated by extruding, dropwise, a cationic cellulose nanofibril (CCNF) dispersion into an oppositely charged poly(acrylic acid) (PAA) bath. The SH have a solid-like CCNF-PAA shell, acting as a semipermeable membrane, and a liquid-like CCNF suspension in the core. Swelling behavior of the SH was dependent on the osmotic pressure of the aging media. Swelling could be suppressed by increasing the ionic strength of the media as this enhanced interfibrillar interactions and thus strengthened the outer gel membrane. We further validated a potential application of SH as reusable matrixes for glucose oxidase (GOx) entrapment, where the SH work as microreactors from which substrate and product are freely able to migrate through the SH shell while avoiding enzyme leakage.

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author
; ; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
biocatalysis, cellulose, complex precipitate, enzyme entrapment, glucose oxidase
in
ACS Applied Polymer Materials
volume
2
issue
3
pages
9 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:85099652317
ISSN
2637-6105
DOI
10.1021/acsapm.9b01086
language
English
LU publication?
no
additional info
Publisher Copyright: Copyright © 2020 American Chemical Society.
id
c19366bd-d504-46ef-ac35-67641c043f41
date added to LUP
2022-07-12 15:42:38
date last changed
2022-08-12 12:55:07
@article{c19366bd-d504-46ef-ac35-67641c043f41,
  abstract     = {{<p>Through charge-driven interfacial complexation, we produced millimeter-sized spheroidal hydrogels (SH) with a core-shell structure allowing long-term stability in aqueous media. The SH were fabricated by extruding, dropwise, a cationic cellulose nanofibril (CCNF) dispersion into an oppositely charged poly(acrylic acid) (PAA) bath. The SH have a solid-like CCNF-PAA shell, acting as a semipermeable membrane, and a liquid-like CCNF suspension in the core. Swelling behavior of the SH was dependent on the osmotic pressure of the aging media. Swelling could be suppressed by increasing the ionic strength of the media as this enhanced interfibrillar interactions and thus strengthened the outer gel membrane. We further validated a potential application of SH as reusable matrixes for glucose oxidase (GOx) entrapment, where the SH work as microreactors from which substrate and product are freely able to migrate through the SH shell while avoiding enzyme leakage. </p>}},
  author       = {{Calabrese, Vincenzo and Califano, Davide and da Silva, Marcelo A. and Schmitt, Julien and Bryant, Saffron J. and Hossain, Kazi M. Zakir and Percebom, Ana M. and Pérez Gramatges, Aurora and Scott, Janet L. and Edler, Karen J.}},
  issn         = {{2637-6105}},
  keywords     = {{biocatalysis; cellulose; complex precipitate; enzyme entrapment; glucose oxidase}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  pages        = {{1213--1221}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{ACS Applied Polymer Materials}},
  title        = {{Core-Shell Spheroidal Hydrogels Produced via Charge-Driven Interfacial Complexation}},
  url          = {{http://dx.doi.org/10.1021/acsapm.9b01086}},
  doi          = {{10.1021/acsapm.9b01086}},
  volume       = {{2}},
  year         = {{2020}},
}