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Flavin-Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination

Ismail, Mohamed LU orcid ; Frese, Marcel ; Patschkowski, Thomas ; Ortseifen, Vera ; Niehaus, Karsten and Sewald, Norbert (2019) In Advanced Synthesis and Catalysis 361(11). p.2475-2486
Abstract

Flavin-dependent halogenases selectively introduce halogen substituents into (hetero-)aromatic substrates and require only molecular oxygen and halide salts for this regioselective oxidative CH-functionalization. Genomic analysis of Xanthomonas campestris pv. campestris B100 identified three novel putative members of this enzyme class. They were shown to introduce halogen substituents into, e. g., substituted indoles, while preferring bromide over chloride. (Figure presented.).

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
bromination, halogenases, regioselectivity, Xanthomonas
in
Advanced Synthesis and Catalysis
volume
361
issue
11
pages
12 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85062779690
ISSN
1615-4150
DOI
10.1002/adsc.201801591
language
English
LU publication?
no
id
c1a8f7be-d48d-4afc-8ea7-10a51e71f88e
date added to LUP
2023-08-28 11:44:03
date last changed
2023-08-29 13:33:26
@article{c1a8f7be-d48d-4afc-8ea7-10a51e71f88e,
  abstract     = {{<p>Flavin-dependent halogenases selectively introduce halogen substituents into (hetero-)aromatic substrates and require only molecular oxygen and halide salts for this regioselective oxidative CH-functionalization. Genomic analysis of Xanthomonas campestris pv. campestris B100 identified three novel putative members of this enzyme class. They were shown to introduce halogen substituents into, e. g., substituted indoles, while preferring bromide over chloride. (Figure presented.).</p>}},
  author       = {{Ismail, Mohamed and Frese, Marcel and Patschkowski, Thomas and Ortseifen, Vera and Niehaus, Karsten and Sewald, Norbert}},
  issn         = {{1615-4150}},
  keywords     = {{bromination; halogenases; regioselectivity; Xanthomonas}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{11}},
  pages        = {{2475--2486}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Advanced Synthesis and Catalysis}},
  title        = {{Flavin-Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination}},
  url          = {{http://dx.doi.org/10.1002/adsc.201801591}},
  doi          = {{10.1002/adsc.201801591}},
  volume       = {{361}},
  year         = {{2019}},
}