Flavin-Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination
(2019) In Advanced Synthesis and Catalysis 361(11). p.2475-2486- Abstract
Flavin-dependent halogenases selectively introduce halogen substituents into (hetero-)aromatic substrates and require only molecular oxygen and halide salts for this regioselective oxidative CH-functionalization. Genomic analysis of Xanthomonas campestris pv. campestris B100 identified three novel putative members of this enzyme class. They were shown to introduce halogen substituents into, e. g., substituted indoles, while preferring bromide over chloride. (Figure presented.).
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c1a8f7be-d48d-4afc-8ea7-10a51e71f88e
- author
- Ismail, Mohamed LU ; Frese, Marcel ; Patschkowski, Thomas ; Ortseifen, Vera ; Niehaus, Karsten and Sewald, Norbert
- publishing date
- 2019-06-06
- type
- Contribution to journal
- publication status
- published
- keywords
- bromination, halogenases, regioselectivity, Xanthomonas
- in
- Advanced Synthesis and Catalysis
- volume
- 361
- issue
- 11
- pages
- 12 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85062779690
- ISSN
- 1615-4150
- DOI
- 10.1002/adsc.201801591
- language
- English
- LU publication?
- no
- id
- c1a8f7be-d48d-4afc-8ea7-10a51e71f88e
- date added to LUP
- 2023-08-28 11:44:03
- date last changed
- 2023-08-29 13:33:26
@article{c1a8f7be-d48d-4afc-8ea7-10a51e71f88e, abstract = {{<p>Flavin-dependent halogenases selectively introduce halogen substituents into (hetero-)aromatic substrates and require only molecular oxygen and halide salts for this regioselective oxidative CH-functionalization. Genomic analysis of Xanthomonas campestris pv. campestris B100 identified three novel putative members of this enzyme class. They were shown to introduce halogen substituents into, e. g., substituted indoles, while preferring bromide over chloride. (Figure presented.).</p>}}, author = {{Ismail, Mohamed and Frese, Marcel and Patschkowski, Thomas and Ortseifen, Vera and Niehaus, Karsten and Sewald, Norbert}}, issn = {{1615-4150}}, keywords = {{bromination; halogenases; regioselectivity; Xanthomonas}}, language = {{eng}}, month = {{06}}, number = {{11}}, pages = {{2475--2486}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Advanced Synthesis and Catalysis}}, title = {{Flavin-Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination}}, url = {{http://dx.doi.org/10.1002/adsc.201801591}}, doi = {{10.1002/adsc.201801591}}, volume = {{361}}, year = {{2019}}, }