The density difference between tissue and neural probes is a key factor for glial scarring.
(2013) In Scientific Reports 3(Oct 15).- Abstract
- A key to successful chronic neural interfacing is to achieve minimal glial scarring surrounding the implants, as the astrocytes and microglia may functionally insulate the interface. A possible explanation for the development of these reactions is mechanical forces arising between the implants and the brain. Here, we show that the difference between the density of neural probes and that of the tissue, and the resulting inertial forces, are key factors for the development of the glial scar. Two probes of similar size, shape, surface structure and elastic modulus but differing greatly in density were implanted into the rat brain. After six weeks, significantly lower astrocytic and microglial reactions were found surrounding the low-density... (More)
- A key to successful chronic neural interfacing is to achieve minimal glial scarring surrounding the implants, as the astrocytes and microglia may functionally insulate the interface. A possible explanation for the development of these reactions is mechanical forces arising between the implants and the brain. Here, we show that the difference between the density of neural probes and that of the tissue, and the resulting inertial forces, are key factors for the development of the glial scar. Two probes of similar size, shape, surface structure and elastic modulus but differing greatly in density were implanted into the rat brain. After six weeks, significantly lower astrocytic and microglial reactions were found surrounding the low-density probes, approaching no reaction at all. This provides a major key to design fully biocompatible neural interfaces and a new platform for in vivo assays of tissue reactions to probes with differing materials, surface structures, and shapes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4143240
- author
- Lind, Gustav LU ; Eriksson Linsmeier, Cecilia LU and Schouenborg, Jens LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 3
- issue
- Oct 15
- article number
- 2942
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000325608800003
- pmid:24127004
- scopus:84900338328
- pmid:24127004
- ISSN
- 2045-2322
- DOI
- 10.1038/srep02942
- language
- English
- LU publication?
- yes
- id
- c1a9fe0b-d48b-4b03-b585-f83ae42cfeaf (old id 4143240)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24127004?dopt=Abstract
- date added to LUP
- 2016-04-01 13:47:51
- date last changed
- 2022-09-26 14:48:16
@article{c1a9fe0b-d48b-4b03-b585-f83ae42cfeaf,
abstract = {{A key to successful chronic neural interfacing is to achieve minimal glial scarring surrounding the implants, as the astrocytes and microglia may functionally insulate the interface. A possible explanation for the development of these reactions is mechanical forces arising between the implants and the brain. Here, we show that the difference between the density of neural probes and that of the tissue, and the resulting inertial forces, are key factors for the development of the glial scar. Two probes of similar size, shape, surface structure and elastic modulus but differing greatly in density were implanted into the rat brain. After six weeks, significantly lower astrocytic and microglial reactions were found surrounding the low-density probes, approaching no reaction at all. This provides a major key to design fully biocompatible neural interfaces and a new platform for in vivo assays of tissue reactions to probes with differing materials, surface structures, and shapes.}},
author = {{Lind, Gustav and Eriksson Linsmeier, Cecilia and Schouenborg, Jens}},
issn = {{2045-2322}},
language = {{eng}},
number = {{Oct 15}},
publisher = {{Nature Publishing Group}},
series = {{Scientific Reports}},
title = {{The density difference between tissue and neural probes is a key factor for glial scarring.}},
url = {{https://lup.lub.lu.se/search/files/3596992/4254139.pdf}},
doi = {{10.1038/srep02942}},
volume = {{3}},
year = {{2013}},
}