Dose painting based on tumor uptake of Cu-ATSM and FDG : a comparative study
Clausen, Malene Martini ; Hansen, Anders Elias ; Lundemann, Michael ; Hollensen, Christian ; Pommer, Tobias ; Munck Af Rosenschöld, Per LU
; Kristensen, Annemarie Thuri
; Kjær, Andreas
; McEvoy, Fintan J.
and Engelholm, Svend Aage
(2014)
In Radiation oncology (London, England)
9.
- Abstract
BACKGROUND: Hypoxia and increased glycolytic activity of tumors are associated with poor prognosis. The purpose of this study was to investigate differences in radiotherapy (RT) dose painting based on the uptake of 2-deoxy-2-[(18) F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer, copper(II)diacetyl-bis(N(4))-methylsemithiocarbazone (Cu-ATSM) using spontaneous clinical canine tumor models.
METHODS: Positron emission tomography/computed tomography scans of five spontaneous canine sarcomas and carcinomas were obtained; FDG on day 1 and (64)Cu-ATSM on day 2 and 3 (approx. 3 and 24 hours pi.). Sub-volumes for dose escalation were defined by a threshold-based method for both tracers and five dose escalation levels were formed... (More)
BACKGROUND: Hypoxia and increased glycolytic activity of tumors are associated with poor prognosis. The purpose of this study was to investigate differences in radiotherapy (RT) dose painting based on the uptake of 2-deoxy-2-[(18) F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer, copper(II)diacetyl-bis(N(4))-methylsemithiocarbazone (Cu-ATSM) using spontaneous clinical canine tumor models.
METHODS: Positron emission tomography/computed tomography scans of five spontaneous canine sarcomas and carcinomas were obtained; FDG on day 1 and (64)Cu-ATSM on day 2 and 3 (approx. 3 and 24 hours pi.). Sub-volumes for dose escalation were defined by a threshold-based method for both tracers and five dose escalation levels were formed in each sub-volume. Volumetric modulated arc therapy plans were optimized based on the dose escalation regions for each scan for a total of three dose plans for each dog. The prescription dose for the GTV was 45 Gy (100%) and it was linearly escalated to a maximum of 150%. The correlations between dose painting plans were analyzed with construction of dose distribution density maps and quality volume histograms (QVH). Correlation between high-dose regions was investigated with Dice correlation coefficients.
RESULTS: Comparison of dose plans revealed varying degree of correlation between cases. Some cases displayed a separation of high-dose regions in the comparison of FDG vs. (64)Cu-ATSM dose plans at both time points. Among the Dice correlation coefficients, the high dose regions showed the lowest degree of agreement, indicating potential benefit of using multiple tracers for dose painting. QVH analysis revealed that FDG-based dose painting plans adequately covered approximately 50% of the hypoxic regions.
CONCLUSION: Radiotherapy plans optimized with the current approach for cut-off values and dose region definitions based on FDG, (64)Cu-ATSM 3 h and 24 h uptake in canine tumors had different localization of the regional dose escalation levels. This indicates that (64)Cu-ATSM at two different time-points and FDG provide different biological information that has to be taken into account when using the dose painting strategy in radiotherapy treatment planning.
(Less)
- author
- Clausen, Malene Martini
; Hansen, Anders Elias
; Lundemann, Michael
; Hollensen, Christian
; Pommer, Tobias
; Munck Af Rosenschöld, Per
LU
; Kristensen, Annemarie Thuri
; Kjær, Andreas
; McEvoy, Fintan J.
and Engelholm, Svend Aage
- publishing date
- 2014-10-16
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Radiation oncology (London, England)
- volume
- 9
- pages
- 1 pages
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85017319045
- pmid:25319766
- ISSN
- 1748-717X
- DOI
- 10.1186/s13014-014-0228-0
- language
- English
- LU publication?
- no
- id
- c1acbf26-ac50-4d51-a041-6e26bbe01259
- date added to LUP
- 2020-07-28 08:46:21
- date last changed
- 2024-06-12 19:30:52
@article{c1acbf26-ac50-4d51-a041-6e26bbe01259,
abstract = {{<p>BACKGROUND: Hypoxia and increased glycolytic activity of tumors are associated with poor prognosis. The purpose of this study was to investigate differences in radiotherapy (RT) dose painting based on the uptake of 2-deoxy-2-[(18) F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer, copper(II)diacetyl-bis(N(4))-methylsemithiocarbazone (Cu-ATSM) using spontaneous clinical canine tumor models.</p><p>METHODS: Positron emission tomography/computed tomography scans of five spontaneous canine sarcomas and carcinomas were obtained; FDG on day 1 and (64)Cu-ATSM on day 2 and 3 (approx. 3 and 24 hours pi.). Sub-volumes for dose escalation were defined by a threshold-based method for both tracers and five dose escalation levels were formed in each sub-volume. Volumetric modulated arc therapy plans were optimized based on the dose escalation regions for each scan for a total of three dose plans for each dog. The prescription dose for the GTV was 45 Gy (100%) and it was linearly escalated to a maximum of 150%. The correlations between dose painting plans were analyzed with construction of dose distribution density maps and quality volume histograms (QVH). Correlation between high-dose regions was investigated with Dice correlation coefficients.</p><p>RESULTS: Comparison of dose plans revealed varying degree of correlation between cases. Some cases displayed a separation of high-dose regions in the comparison of FDG vs. (64)Cu-ATSM dose plans at both time points. Among the Dice correlation coefficients, the high dose regions showed the lowest degree of agreement, indicating potential benefit of using multiple tracers for dose painting. QVH analysis revealed that FDG-based dose painting plans adequately covered approximately 50% of the hypoxic regions.</p><p>CONCLUSION: Radiotherapy plans optimized with the current approach for cut-off values and dose region definitions based on FDG, (64)Cu-ATSM 3 h and 24 h uptake in canine tumors had different localization of the regional dose escalation levels. This indicates that (64)Cu-ATSM at two different time-points and FDG provide different biological information that has to be taken into account when using the dose painting strategy in radiotherapy treatment planning.</p>}},
author = {{Clausen, Malene Martini and Hansen, Anders Elias and Lundemann, Michael and Hollensen, Christian and Pommer, Tobias and Munck Af Rosenschöld, Per and Kristensen, Annemarie Thuri and Kjær, Andreas and McEvoy, Fintan J. and Engelholm, Svend Aage}},
issn = {{1748-717X}},
language = {{eng}},
month = {{10}},
publisher = {{BioMed Central (BMC)}},
series = {{Radiation oncology (London, England)}},
title = {{Dose painting based on tumor uptake of Cu-ATSM and FDG : a comparative study}},
url = {{http://dx.doi.org/10.1186/s13014-014-0228-0}},
doi = {{10.1186/s13014-014-0228-0}},
volume = {{9}},
year = {{2014}},
}