Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Development of Ultra-High Dose Rate (FLASH) Particle Therapy

Kim, Michele M. ; Darafsheh, Arash ; Schuemann, Jan ; Dokic, Ivana ; Lundh, Olle LU ; Zhao, Tianyu ; Ramos-Mendez, Jose ; Dong, Lei and Petersson, Kristoffer LU (2022) In IEEE Transactions on Radiation and Plasma Medical Sciences 6(3). p.252-262
Abstract

Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy. The goal of this review is to summarize the studies performed to-date with proton, electron, and heavy ion FLASH radiotherapy, with particular emphasis on the physical aspects of each study and the advantages and disadvantages of each modality. Beam delivery parameters, experimental set-up, and the dosimetry tools used are described for each FLASH modality. In addition, modeling efforts and treatment planning for FLASH radiotherapy is discussed... (More)

Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy. The goal of this review is to summarize the studies performed to-date with proton, electron, and heavy ion FLASH radiotherapy, with particular emphasis on the physical aspects of each study and the advantages and disadvantages of each modality. Beam delivery parameters, experimental set-up, and the dosimetry tools used are described for each FLASH modality. In addition, modeling efforts and treatment planning for FLASH radiotherapy is discussed along with potential drawbacks when translated into the clinical setting. The final section concludes with further questions that have yet to be answered before safe clinical implementation of FLASH radiotherapy.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cyclotrons, electron radiation, FLASH effect modeling., FLASH radiotherapy, heavy-ion radiation, Laser beams, Oncology, Photonics, proton radiation, Protons, Synchrocyclotrons, Tumors
in
IEEE Transactions on Radiation and Plasma Medical Sciences
volume
6
issue
3
pages
252 - 262
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • scopus:85109421741
ISSN
2469-7311
DOI
10.1109/TRPMS.2021.3091406
language
English
LU publication?
yes
additional info
Publisher Copyright: IEEE
id
c20b18d4-2846-4d2d-be61-895d84e5abdc
date added to LUP
2021-11-03 18:20:53
date last changed
2022-06-29 20:26:50
@article{c20b18d4-2846-4d2d-be61-895d84e5abdc,
  abstract     = {{<p>Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy. The goal of this review is to summarize the studies performed to-date with proton, electron, and heavy ion FLASH radiotherapy, with particular emphasis on the physical aspects of each study and the advantages and disadvantages of each modality. Beam delivery parameters, experimental set-up, and the dosimetry tools used are described for each FLASH modality. In addition, modeling efforts and treatment planning for FLASH radiotherapy is discussed along with potential drawbacks when translated into the clinical setting. The final section concludes with further questions that have yet to be answered before safe clinical implementation of FLASH radiotherapy.</p>}},
  author       = {{Kim, Michele M. and Darafsheh, Arash and Schuemann, Jan and Dokic, Ivana and Lundh, Olle and Zhao, Tianyu and Ramos-Mendez, Jose and Dong, Lei and Petersson, Kristoffer}},
  issn         = {{2469-7311}},
  keywords     = {{Cyclotrons; electron radiation; FLASH effect modeling.; FLASH radiotherapy; heavy-ion radiation; Laser beams; Oncology; Photonics; proton radiation; Protons; Synchrocyclotrons; Tumors}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{252--262}},
  publisher    = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
  series       = {{IEEE Transactions on Radiation and Plasma Medical Sciences}},
  title        = {{Development of Ultra-High Dose Rate (FLASH) Particle Therapy}},
  url          = {{http://dx.doi.org/10.1109/TRPMS.2021.3091406}},
  doi          = {{10.1109/TRPMS.2021.3091406}},
  volume       = {{6}},
  year         = {{2022}},
}