Development of Ultra-High Dose Rate (FLASH) Particle Therapy
(2022) In IEEE Transactions on Radiation and Plasma Medical Sciences 6(3). p.252-262- Abstract
Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy. The goal of this review is to summarize the studies performed to-date with proton, electron, and heavy ion FLASH radiotherapy, with particular emphasis on the physical aspects of each study and the advantages and disadvantages of each modality. Beam delivery parameters, experimental set-up, and the dosimetry tools used are described for each FLASH modality. In addition, modeling efforts and treatment planning for FLASH radiotherapy is discussed... (More)
Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy. The goal of this review is to summarize the studies performed to-date with proton, electron, and heavy ion FLASH radiotherapy, with particular emphasis on the physical aspects of each study and the advantages and disadvantages of each modality. Beam delivery parameters, experimental set-up, and the dosimetry tools used are described for each FLASH modality. In addition, modeling efforts and treatment planning for FLASH radiotherapy is discussed along with potential drawbacks when translated into the clinical setting. The final section concludes with further questions that have yet to be answered before safe clinical implementation of FLASH radiotherapy.
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- author
- Kim, Michele M. ; Darafsheh, Arash ; Schuemann, Jan ; Dokic, Ivana ; Lundh, Olle LU ; Zhao, Tianyu ; Ramos-Mendez, Jose ; Dong, Lei and Petersson, Kristoffer LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cyclotrons, electron radiation, FLASH effect modeling., FLASH radiotherapy, heavy-ion radiation, Laser beams, Oncology, Photonics, proton radiation, Protons, Synchrocyclotrons, Tumors
- in
- IEEE Transactions on Radiation and Plasma Medical Sciences
- volume
- 6
- issue
- 3
- pages
- 252 - 262
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- external identifiers
-
- scopus:85109421741
- ISSN
- 2469-7311
- DOI
- 10.1109/TRPMS.2021.3091406
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: IEEE
- id
- c20b18d4-2846-4d2d-be61-895d84e5abdc
- date added to LUP
- 2021-11-03 18:20:53
- date last changed
- 2022-06-29 20:26:50
@article{c20b18d4-2846-4d2d-be61-895d84e5abdc, abstract = {{<p>Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy. The goal of this review is to summarize the studies performed to-date with proton, electron, and heavy ion FLASH radiotherapy, with particular emphasis on the physical aspects of each study and the advantages and disadvantages of each modality. Beam delivery parameters, experimental set-up, and the dosimetry tools used are described for each FLASH modality. In addition, modeling efforts and treatment planning for FLASH radiotherapy is discussed along with potential drawbacks when translated into the clinical setting. The final section concludes with further questions that have yet to be answered before safe clinical implementation of FLASH radiotherapy.</p>}}, author = {{Kim, Michele M. and Darafsheh, Arash and Schuemann, Jan and Dokic, Ivana and Lundh, Olle and Zhao, Tianyu and Ramos-Mendez, Jose and Dong, Lei and Petersson, Kristoffer}}, issn = {{2469-7311}}, keywords = {{Cyclotrons; electron radiation; FLASH effect modeling.; FLASH radiotherapy; heavy-ion radiation; Laser beams; Oncology; Photonics; proton radiation; Protons; Synchrocyclotrons; Tumors}}, language = {{eng}}, number = {{3}}, pages = {{252--262}}, publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}}, series = {{IEEE Transactions on Radiation and Plasma Medical Sciences}}, title = {{Development of Ultra-High Dose Rate (FLASH) Particle Therapy}}, url = {{http://dx.doi.org/10.1109/TRPMS.2021.3091406}}, doi = {{10.1109/TRPMS.2021.3091406}}, volume = {{6}}, year = {{2022}}, }