Safer proteinase treatment of sciatica. A biochemical preview of chymopapain inhibitors
Grubb, A LU
(1988)
In Acta Orthopaedica Scandinavica
59(1).
p.63-65
- Abstract
- As pointed out in the preceding review (Nachemson and Rydevik 1988), the most serious and common complications of chymopapain treatment of patients with sciatica due to disc herniation are cerebral or subarachnoid hemorrhages and allergic manifestations. Recent progress in biochemical and physiologic studies of cysteine proteinases and their inhibitors allows some speculation on how these complications in the future might be alleviated or avoided and on how the efficiency of proteinase treatment of patients with sciatica might be increased.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c23e3b4b-2007-4f60-8da8-c17cfc48482e
- author
- Grubb, A
LU
- organization
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Chymopapain/adverse effects, Cysteine Endopeptidases, Cysteine Proteinase Inhibitors, Intervertebral Disc Displacement/drug therapy, Protease Inhibitors/therapeutic use, Sciatica/drug therapy
- in
- Acta Orthopaedica Scandinavica
- volume
- 59
- issue
- 1
- pages
- 63 - 65
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:0023899361
- pmid:3281407
- ISSN
- 0001-6470
- DOI
- 10.3109/17453678809149347
- language
- English
- LU publication?
- yes
- id
- c23e3b4b-2007-4f60-8da8-c17cfc48482e
- date added to LUP
- 2021-10-27 08:16:13
- date last changed
- 2024-01-12 02:57:25
@article{c23e3b4b-2007-4f60-8da8-c17cfc48482e,
abstract = {{As pointed out in the preceding review (Nachemson and Rydevik 1988), the most serious and common complications of chymopapain treatment of patients with sciatica due to disc herniation are cerebral or subarachnoid hemorrhages and allergic manifestations. Recent progress in biochemical and physiologic studies of cysteine proteinases and their inhibitors allows some speculation on how these complications in the future might be alleviated or avoided and on how the efficiency of proteinase treatment of patients with sciatica might be increased.}},
author = {{Grubb, A}},
issn = {{0001-6470}},
keywords = {{Chymopapain/adverse effects; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Intervertebral Disc Displacement/drug therapy; Protease Inhibitors/therapeutic use; Sciatica/drug therapy}},
language = {{eng}},
number = {{1}},
pages = {{63--65}},
publisher = {{Taylor & Francis}},
series = {{Acta Orthopaedica Scandinavica}},
title = {{Safer proteinase treatment of sciatica. A biochemical preview of chymopapain inhibitors}},
url = {{http://dx.doi.org/10.3109/17453678809149347}},
doi = {{10.3109/17453678809149347}},
volume = {{59}},
year = {{1988}},
}