Preoperative alcoholism and postoperative morbidity
(1999) In British Journal of Surgery 86(7). p.869-874- Abstract
Background: Preoperative risk assessment has become part of daily clinical practice, but preoperative alcohol abuse has not received much attention. Methods: A Medline search was carried out to identify original papers published from 1967 to 1998. Relevant articles on postoperative morbidity in alcohol abusers were used to evaluate the evidence. Results: Prospective and retrospective studies demonstrate a twofoId to threefold increase in postoperative morbidity in alcohol abusers, the most frequent complications being infections, bleeding and cardiopulmonarly insufficiency. Wound complications account for about half of the morbidity. The pathogenic mechanisms include preoperative immune incompetence, subclinical cardiac insufficiency... (More)
Background: Preoperative risk assessment has become part of daily clinical practice, but preoperative alcohol abuse has not received much attention. Methods: A Medline search was carried out to identify original papers published from 1967 to 1998. Relevant articles on postoperative morbidity in alcohol abusers were used to evaluate the evidence. Results: Prospective and retrospective studies demonstrate a twofoId to threefold increase in postoperative morbidity in alcohol abusers, the most frequent complications being infections, bleeding and cardiopulmonarly insufficiency. Wound complications account for about half of the morbidity. The pathogenic mechanisms include preoperative immune incompetence, subclinical cardiac insufficiency and haemostatic imbalance. In addition, surgical trauma and/or postoperative abstinence result in an exaggerated stress response, which may further contribute to postoperative morbidity. Conclusion: Alcohol consumption should be included in the preoperative assessment of likely postoperative outcome. Reduction of postoperative morbidity in alcohol abusers may include preoperative alcohol abstinence to improve organ function, or perioperative alcohol administration to avoid the abstinence response.
(Less)
- author
- Tønnesen, H. LU and Kehlet, H.
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- in
- British Journal of Surgery
- volume
- 86
- issue
- 7
- pages
- 6 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:10417555
- scopus:0032801989
- ISSN
- 0007-1323
- DOI
- 10.1046/j.1365-2168.1999.01181.x
- language
- English
- LU publication?
- no
- id
- c25818c2-d308-4dc2-b1aa-9b168879fab8
- date added to LUP
- 2022-10-27 16:48:29
- date last changed
- 2024-03-06 16:11:59
@article{c25818c2-d308-4dc2-b1aa-9b168879fab8,
abstract = {{<p>Background: Preoperative risk assessment has become part of daily clinical practice, but preoperative alcohol abuse has not received much attention. Methods: A Medline search was carried out to identify original papers published from 1967 to 1998. Relevant articles on postoperative morbidity in alcohol abusers were used to evaluate the evidence. Results: Prospective and retrospective studies demonstrate a twofoId to threefold increase in postoperative morbidity in alcohol abusers, the most frequent complications being infections, bleeding and cardiopulmonarly insufficiency. Wound complications account for about half of the morbidity. The pathogenic mechanisms include preoperative immune incompetence, subclinical cardiac insufficiency and haemostatic imbalance. In addition, surgical trauma and/or postoperative abstinence result in an exaggerated stress response, which may further contribute to postoperative morbidity. Conclusion: Alcohol consumption should be included in the preoperative assessment of likely postoperative outcome. Reduction of postoperative morbidity in alcohol abusers may include preoperative alcohol abstinence to improve organ function, or perioperative alcohol administration to avoid the abstinence response.</p>}},
author = {{Tønnesen, H. and Kehlet, H.}},
issn = {{0007-1323}},
language = {{eng}},
number = {{7}},
pages = {{869--874}},
publisher = {{Oxford University Press}},
series = {{British Journal of Surgery}},
title = {{Preoperative alcoholism and postoperative morbidity}},
url = {{http://dx.doi.org/10.1046/j.1365-2168.1999.01181.x}},
doi = {{10.1046/j.1365-2168.1999.01181.x}},
volume = {{86}},
year = {{1999}},
}