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A breakpoint map of recurrent chromosomal rearrangements in human neoplasia

Mitelman, Felix LU ; Mertens, Fredrik LU and Johansson, Bertil LU (1997) In Nature Genetics 15(4). p.417-474
Abstract

Cytogenetic studies over the past few decades have revealed clonal chromosomal aberrations in almost 27,000 human neoplasms. Many of these neoplasia-associated chromosomal abnormalities have been characterised at the molecular level, revealing previously unknown genes that are closely associated with the tumorigenic process. Information on chromosome changes in neoplasia is growing rapidly, making it difficult to identify all recurrent chromosomal aberrations. We have developed a computer program to ascertain, for the first time, all recurrent structural abnormalities in all haematological malignancies and solid tumours published up to June 1996. Out of 26,523 cases, a total of 215 balanced and 1,588 unbalanced recurrent aberrations... (More)

Cytogenetic studies over the past few decades have revealed clonal chromosomal aberrations in almost 27,000 human neoplasms. Many of these neoplasia-associated chromosomal abnormalities have been characterised at the molecular level, revealing previously unknown genes that are closely associated with the tumorigenic process. Information on chromosome changes in neoplasia is growing rapidly, making it difficult to identify all recurrent chromosomal aberrations. We have developed a computer program to ascertain, for the first time, all recurrent structural abnormalities in all haematological malignancies and solid tumours published up to June 1996. Out of 26,523 cases, a total of 215 balanced and 1,588 unbalanced recurrent aberrations were identified among 75 different neoplastic disorders. Our compilation of all recurrent balanced and unbalanced neoplasia-associated rearrangements should help in directing future efforts aimed at identifying the molecular mechanisms involved in tumorigenesis.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Genetics
volume
15
issue
4
pages
58 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:0030999555
ISSN
1061-4036
DOI
10.1038/ng0497supp-417
language
English
LU publication?
yes
id
c29ed9f9-9bc6-4272-b51e-1a2d95ffc0ed
date added to LUP
2016-12-15 13:46:59
date last changed
2017-09-17 09:34:35
@article{c29ed9f9-9bc6-4272-b51e-1a2d95ffc0ed,
  abstract     = {<p>Cytogenetic studies over the past few decades have revealed clonal chromosomal aberrations in almost 27,000 human neoplasms. Many of these neoplasia-associated chromosomal abnormalities have been characterised at the molecular level, revealing previously unknown genes that are closely associated with the tumorigenic process. Information on chromosome changes in neoplasia is growing rapidly, making it difficult to identify all recurrent chromosomal aberrations. We have developed a computer program to ascertain, for the first time, all recurrent structural abnormalities in all haematological malignancies and solid tumours published up to June 1996. Out of 26,523 cases, a total of 215 balanced and 1,588 unbalanced recurrent aberrations were identified among 75 different neoplastic disorders. Our compilation of all recurrent balanced and unbalanced neoplasia-associated rearrangements should help in directing future efforts aimed at identifying the molecular mechanisms involved in tumorigenesis.</p>},
  author       = {Mitelman, Felix and Mertens, Fredrik and Johansson, Bertil},
  issn         = {1061-4036},
  language     = {eng},
  month        = {04},
  number       = {4},
  pages        = {417--474},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {A breakpoint map of recurrent chromosomal rearrangements in human neoplasia},
  url          = {http://dx.doi.org/10.1038/ng0497supp-417},
  volume       = {15},
  year         = {1997},
}