A breakpoint map of recurrent chromosomal rearrangements in human neoplasia
Mitelman, Felix LU
; Mertens, Fredrik
LU
and Johansson, Bertil
LU
(1997)
In Nature Genetics
15(4).
p.417-474
- Abstract
Cytogenetic studies over the past few decades have revealed clonal chromosomal aberrations in almost 27,000 human neoplasms. Many of these neoplasia-associated chromosomal abnormalities have been characterised at the molecular level, revealing previously unknown genes that are closely associated with the tumorigenic process. Information on chromosome changes in neoplasia is growing rapidly, making it difficult to identify all recurrent chromosomal aberrations. We have developed a computer program to ascertain, for the first time, all recurrent structural abnormalities in all haematological malignancies and solid tumours published up to June 1996. Out of 26,523 cases, a total of 215 balanced and 1,588 unbalanced recurrent aberrations... (More)
Cytogenetic studies over the past few decades have revealed clonal chromosomal aberrations in almost 27,000 human neoplasms. Many of these neoplasia-associated chromosomal abnormalities have been characterised at the molecular level, revealing previously unknown genes that are closely associated with the tumorigenic process. Information on chromosome changes in neoplasia is growing rapidly, making it difficult to identify all recurrent chromosomal aberrations. We have developed a computer program to ascertain, for the first time, all recurrent structural abnormalities in all haematological malignancies and solid tumours published up to June 1996. Out of 26,523 cases, a total of 215 balanced and 1,588 unbalanced recurrent aberrations were identified among 75 different neoplastic disorders. Our compilation of all recurrent balanced and unbalanced neoplasia-associated rearrangements should help in directing future efforts aimed at identifying the molecular mechanisms involved in tumorigenesis.
(Less)
- author
- Mitelman, Felix
LU
; Mertens, Fredrik
LU
and Johansson, Bertil
LU
- organization
- publishing date
- 1997-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Genetics
- volume
- 15
- issue
- 4
- pages
- 58 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:9140409
- scopus:0030999555
- ISSN
- 1061-4036
- DOI
- 10.1038/ng0497supp-417
- language
- English
- LU publication?
- yes
- id
- c29ed9f9-9bc6-4272-b51e-1a2d95ffc0ed
- date added to LUP
- 2016-12-15 13:46:59
- date last changed
- 2025-03-08 22:21:22
@article{c29ed9f9-9bc6-4272-b51e-1a2d95ffc0ed,
abstract = {{<p>Cytogenetic studies over the past few decades have revealed clonal chromosomal aberrations in almost 27,000 human neoplasms. Many of these neoplasia-associated chromosomal abnormalities have been characterised at the molecular level, revealing previously unknown genes that are closely associated with the tumorigenic process. Information on chromosome changes in neoplasia is growing rapidly, making it difficult to identify all recurrent chromosomal aberrations. We have developed a computer program to ascertain, for the first time, all recurrent structural abnormalities in all haematological malignancies and solid tumours published up to June 1996. Out of 26,523 cases, a total of 215 balanced and 1,588 unbalanced recurrent aberrations were identified among 75 different neoplastic disorders. Our compilation of all recurrent balanced and unbalanced neoplasia-associated rearrangements should help in directing future efforts aimed at identifying the molecular mechanisms involved in tumorigenesis.</p>}},
author = {{Mitelman, Felix and Mertens, Fredrik and Johansson, Bertil}},
issn = {{1061-4036}},
language = {{eng}},
month = {{04}},
number = {{4}},
pages = {{417--474}},
publisher = {{Nature Publishing Group}},
series = {{Nature Genetics}},
title = {{A breakpoint map of recurrent chromosomal rearrangements in human neoplasia}},
url = {{http://dx.doi.org/10.1038/ng0497supp-417}},
doi = {{10.1038/ng0497supp-417}},
volume = {{15}},
year = {{1997}},
}