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Simultaneous production of antioxidants and starch from the microalga Chlorella sorokiniana

Petruk, Ganna LU orcid ; Gifuni, Imma ; Illiano, Anna ; Roxo, Mariana ; Pinto, Gabriella ; Amoresano, Angela ; Marzocchella, Antonio ; Piccoli, Renata ; Wink, Michael and Olivieri, Giuseppe , et al. (2018) In Algal Research 34. p.164-174
Abstract

In recent years, microalgae have gained considerable importance as potential source of biofuels and bioplastics. However, these markets are still developing, as the high costs of cultivation ask for exploiting microalgae into new areas and with a biorefinery approach towards a multicomponent cascade extraction process. Here, a sequential processing strategy was used to extract starch with high yield from Chlorella sorokiniana under biocompatible conditions. The extract residue was then tested as a potential source of antioxidants. We found a strong protective activity of the extract residue towards oxidative stress in vitro on human colon cancer cells and in vivo on Caenorhabditis elegans nematodes, by inhibiting ROS production and... (More)

In recent years, microalgae have gained considerable importance as potential source of biofuels and bioplastics. However, these markets are still developing, as the high costs of cultivation ask for exploiting microalgae into new areas and with a biorefinery approach towards a multicomponent cascade extraction process. Here, a sequential processing strategy was used to extract starch with high yield from Chlorella sorokiniana under biocompatible conditions. The extract residue was then tested as a potential source of antioxidants. We found a strong protective activity of the extract residue towards oxidative stress in vitro on human colon cancer cells and in vivo on Caenorhabditis elegans nematodes, by inhibiting ROS production and activating DAF-16/FOXO transcription factor pathway. A pool of molecules from three different classes (fatty acids, photosynthetic pigments and carotenoids) was identified as responsible for the antioxidant activity. To our knowledge, this is the first report on the obtainment, from a “waste” fraction, of high value products endowed with antioxidant activity tested in cell-based models and in vivo.

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publishing date
type
Contribution to journal
publication status
published
keywords
Antioxidants, C. elegans, Chlorella sorokiniana, Eukaryotic cells, Microalgae
in
Algal Research
volume
34
pages
164 - 174
publisher
Elsevier
external identifiers
  • scopus:85050353210
ISSN
2211-9264
DOI
10.1016/j.algal.2018.07.012
language
English
LU publication?
no
additional info
Publisher Copyright: © 2018 Elsevier B.V.
id
c2b416d2-3d2e-4521-a283-b1e2a77f2dd4
date added to LUP
2025-01-21 15:42:48
date last changed
2025-01-21 16:27:39
@article{c2b416d2-3d2e-4521-a283-b1e2a77f2dd4,
  abstract     = {{<p>In recent years, microalgae have gained considerable importance as potential source of biofuels and bioplastics. However, these markets are still developing, as the high costs of cultivation ask for exploiting microalgae into new areas and with a biorefinery approach towards a multicomponent cascade extraction process. Here, a sequential processing strategy was used to extract starch with high yield from Chlorella sorokiniana under biocompatible conditions. The extract residue was then tested as a potential source of antioxidants. We found a strong protective activity of the extract residue towards oxidative stress in vitro on human colon cancer cells and in vivo on Caenorhabditis elegans nematodes, by inhibiting ROS production and activating DAF-16/FOXO transcription factor pathway. A pool of molecules from three different classes (fatty acids, photosynthetic pigments and carotenoids) was identified as responsible for the antioxidant activity. To our knowledge, this is the first report on the obtainment, from a “waste” fraction, of high value products endowed with antioxidant activity tested in cell-based models and in vivo.</p>}},
  author       = {{Petruk, Ganna and Gifuni, Imma and Illiano, Anna and Roxo, Mariana and Pinto, Gabriella and Amoresano, Angela and Marzocchella, Antonio and Piccoli, Renata and Wink, Michael and Olivieri, Giuseppe and Monti, Daria Maria}},
  issn         = {{2211-9264}},
  keywords     = {{Antioxidants; C. elegans; Chlorella sorokiniana; Eukaryotic cells; Microalgae}},
  language     = {{eng}},
  pages        = {{164--174}},
  publisher    = {{Elsevier}},
  series       = {{Algal Research}},
  title        = {{Simultaneous production of antioxidants and starch from the microalga Chlorella sorokiniana}},
  url          = {{http://dx.doi.org/10.1016/j.algal.2018.07.012}},
  doi          = {{10.1016/j.algal.2018.07.012}},
  volume       = {{34}},
  year         = {{2018}},
}