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The serotonergic system in L-DOPA-induced dyskinesia : pre-clinical evidence and clinical perspective

Carta, Manolo and Björklund, Anders LU (2018) In Journal of Neural Transmission 125(8). p.1195-1202
Abstract

During the last decade, the serotonergic system has emerged as a key player in the appearance of L-DOPA-induced dyskinesia in animal models of Parkinson’s disease. Clinical investigations, based on imaging and postmortem analyses, suggest that the serotonin neurons are also involved in the etiology of this complication of long-term L-DOPA treatment in parkinsonian patients. These findings have stimulated efforts to develop new therapies using drugs targeting the malfunctioning serotonin neurons. In this review, we summarize the experimental and clinical data obtained so far and discuss the prospects for further development of this therapeutic strategy.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dyskinesia, L-DOPA, Parkinson’s disease, Serotonin, Serotonin autoreceptors
in
Journal of Neural Transmission
volume
125
issue
8
pages
1195 - 1202
publisher
Springer
external identifiers
  • scopus:85042524623
ISSN
0300-9564
DOI
10.1007/s00702-018-1865-5
language
English
LU publication?
yes
id
c2b66b3c-0e64-4afc-b85d-d494e7244133
date added to LUP
2018-03-23 13:50:15
date last changed
2019-04-23 04:29:48
@article{c2b66b3c-0e64-4afc-b85d-d494e7244133,
  abstract     = {<p>During the last decade, the serotonergic system has emerged as a key player in the appearance of L-DOPA-induced dyskinesia in animal models of Parkinson’s disease. Clinical investigations, based on imaging and postmortem analyses, suggest that the serotonin neurons are also involved in the etiology of this complication of long-term L-DOPA treatment in parkinsonian patients. These findings have stimulated efforts to develop new therapies using drugs targeting the malfunctioning serotonin neurons. In this review, we summarize the experimental and clinical data obtained so far and discuss the prospects for further development of this therapeutic strategy.</p>},
  author       = {Carta, Manolo and Björklund, Anders},
  issn         = {0300-9564},
  keyword      = {Dyskinesia,L-DOPA,Parkinson’s disease,Serotonin,Serotonin autoreceptors},
  language     = {eng},
  number       = {8},
  pages        = {1195--1202},
  publisher    = {Springer},
  series       = {Journal of Neural Transmission},
  title        = {The serotonergic system in L-DOPA-induced dyskinesia : pre-clinical evidence and clinical perspective},
  url          = {http://dx.doi.org/10.1007/s00702-018-1865-5},
  volume       = {125},
  year         = {2018},
}