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Activity of ventral hippocampal parvalbumin interneurons during anxiety

Volitaki, Emmanouela ; Forro, Thomas ; Li, Kaizhen LU orcid ; Nevian, Thomas and Ciocchi, Stéphane (2024) In Cell Reports 43(6).
Abstract
Anxiety plays a key role in guiding behavior in response to potential
threats. Anxiety is mediated by the activation of pyramidal neurons in
the ventral hippocampus (vH), whose activity is controlled by GABAergic
inhibitory interneurons. However, how different vH interneurons might
contribute to anxiety-related processes is unclear. Here, we investigate
the role of vH parvalbumin (PV)-expressing interneurons while mice
transition from safe to more anxiogenic compartments of the elevated
plus maze (EPM). We find that vH PV interneurons increase their activity
in anxiogenic EPM compartments concomitant with dynamic changes in
inhibitory interactions between PV interneurons and pyramidal neurons.... (More)
Anxiety plays a key role in guiding behavior in response to potential
threats. Anxiety is mediated by the activation of pyramidal neurons in
the ventral hippocampus (vH), whose activity is controlled by GABAergic
inhibitory interneurons. However, how different vH interneurons might
contribute to anxiety-related processes is unclear. Here, we investigate
the role of vH parvalbumin (PV)-expressing interneurons while mice
transition from safe to more anxiogenic compartments of the elevated
plus maze (EPM). We find that vH PV interneurons increase their activity
in anxiogenic EPM compartments concomitant with dynamic changes in
inhibitory interactions between PV interneurons and pyramidal neurons.
By optogenetically inhibiting PV interneurons, we induce an increase in
the activity of vH pyramidal neurons and persistent anxiety.
Collectively, our results suggest that vH inhibitory microcircuits may
act as a trigger for enduring anxiety states.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Cell Reports
volume
43
issue
6
article number
114295
publisher
Cell Press
external identifiers
  • scopus:85194062943
  • pmid:38796850
ISSN
2211-1247
DOI
10.1016/j.celrep.2024.114295
language
English
LU publication?
no
additional info
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
id
c2c00526-eaec-461d-916f-d2e6a225fdc3
date added to LUP
2026-09-09 14:07:35
date last changed
2026-09-10 04:00:32
@article{c2c00526-eaec-461d-916f-d2e6a225fdc3,
  abstract     = {{Anxiety plays a key role in guiding behavior in response to potential <br>
threats. Anxiety is mediated by the activation of pyramidal neurons in <br>
the ventral hippocampus (vH), whose activity is controlled by GABAergic <br>
inhibitory interneurons. However, how different vH interneurons might <br>
contribute to anxiety-related processes is unclear. Here, we investigate<br>
 the role of vH parvalbumin (PV)-expressing interneurons while mice <br>
transition from safe to more anxiogenic compartments of the elevated <br>
plus maze (EPM). We find that vH PV interneurons increase their activity<br>
 in anxiogenic EPM compartments concomitant with dynamic changes in <br>
inhibitory interactions between PV interneurons and pyramidal neurons. <br>
By optogenetically inhibiting PV interneurons, we induce an increase in <br>
the activity of vH pyramidal neurons and persistent anxiety. <br>
Collectively, our results suggest that vH inhibitory microcircuits may <br>
act as a trigger for enduring anxiety states.<br>
    <p/>}},
  author       = {{Volitaki, Emmanouela and Forro, Thomas and Li, Kaizhen and Nevian, Thomas and Ciocchi, Stéphane}},
  issn         = {{2211-1247}},
  language     = {{eng}},
  number       = {{6}},
  publisher    = {{Cell Press}},
  series       = {{Cell Reports}},
  title        = {{Activity of ventral hippocampal parvalbumin interneurons during anxiety}},
  url          = {{http://dx.doi.org/10.1016/j.celrep.2024.114295}},
  doi          = {{10.1016/j.celrep.2024.114295}},
  volume       = {{43}},
  year         = {{2024}},
}