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Decrease in all-cause 30-day mortality after bacteraemia over a 15-year period : A population-based cohort study in Denmark in 2000–2014

Holm, Mona Katrine Alberthe ; Jansåker, Filip LU ; Gradel, Kim Oren ; Nielsen, Rikke Thoft ; Østergaard Andersen, Christian ; Jarløv, Jens Otto ; Schønheyder, Henrik Carl and Knudsen, Jenny Dahl (2021) In International Journal of Environmental Research and Public Health 18(11).
Abstract

Introduction: Bacteraemia is a frequent infectious condition that strongly affects morbidity and mortality. The incidence is increasing worldwide. This study explores all-cause 30-day mortality after bacteraemia in two out of Denmark’s five healthcare regions with approximately 2.4 million inhabitants. Methods: Clinically significant bacteraemia episodes (n = 55,257) were identified from a geographically well-defined background population between 2000 and 2014, drawing on population-based data regarding bacterial species and vital status. All-cause 30-day mortality was assessed in relation to bacteraemia episodes, number of patients with analysed blood cultures and the background population. Results: We observed a decreasing trend of... (More)

Introduction: Bacteraemia is a frequent infectious condition that strongly affects morbidity and mortality. The incidence is increasing worldwide. This study explores all-cause 30-day mortality after bacteraemia in two out of Denmark’s five healthcare regions with approximately 2.4 million inhabitants. Methods: Clinically significant bacteraemia episodes (n = 55,257) were identified from a geographically well-defined background population between 2000 and 2014, drawing on population-based data regarding bacterial species and vital status. All-cause 30-day mortality was assessed in relation to bacteraemia episodes, number of patients with analysed blood cultures and the background population. Results: We observed a decreasing trend of all-cause 30-day mortality between 2000 and 2014, both in relation to the number of bacteraemia episodes and the background population. Mortality decreased from 22.7% of the bacteraemia episodes in 2000 to 17.4% in 2014 (annual IRR [95% CI]: 0.983 [0.979–0.987]). In relation to the background population, there were 41 deaths per 100,000 inhabitants in 2000, decreasing to 39 in 2014 (annual IRR [95% CI]: 0.988 [0.982–0.993]). Numbers of inhabitants, bacteraemia episodes, and analysed persons having BCs increased during the period. Conclusions: All-cause 30-day mortality in patients with bacteraemia decreased significantly over a 15-year period.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bacteraemia, Bloodstream infection, Epidemiology, Mortality, Population-based study
in
International Journal of Environmental Research and Public Health
volume
18
issue
11
article number
5982
publisher
MDPI AG
external identifiers
  • pmid:34199587
  • scopus:85107014372
ISSN
1661-7827
DOI
10.3390/ijerph18115982
language
English
LU publication?
yes
id
c2f14ed0-3b44-4b33-8983-63ac8b6ca78a
date added to LUP
2022-03-22 17:11:14
date last changed
2024-04-25 22:49:25
@article{c2f14ed0-3b44-4b33-8983-63ac8b6ca78a,
  abstract     = {{<p>Introduction: Bacteraemia is a frequent infectious condition that strongly affects morbidity and mortality. The incidence is increasing worldwide. This study explores all-cause 30-day mortality after bacteraemia in two out of Denmark’s five healthcare regions with approximately 2.4 million inhabitants. Methods: Clinically significant bacteraemia episodes (n = 55,257) were identified from a geographically well-defined background population between 2000 and 2014, drawing on population-based data regarding bacterial species and vital status. All-cause 30-day mortality was assessed in relation to bacteraemia episodes, number of patients with analysed blood cultures and the background population. Results: We observed a decreasing trend of all-cause 30-day mortality between 2000 and 2014, both in relation to the number of bacteraemia episodes and the background population. Mortality decreased from 22.7% of the bacteraemia episodes in 2000 to 17.4% in 2014 (annual IRR [95% CI]: 0.983 [0.979–0.987]). In relation to the background population, there were 41 deaths per 100,000 inhabitants in 2000, decreasing to 39 in 2014 (annual IRR [95% CI]: 0.988 [0.982–0.993]). Numbers of inhabitants, bacteraemia episodes, and analysed persons having BCs increased during the period. Conclusions: All-cause 30-day mortality in patients with bacteraemia decreased significantly over a 15-year period.</p>}},
  author       = {{Holm, Mona Katrine Alberthe and Jansåker, Filip and Gradel, Kim Oren and Nielsen, Rikke Thoft and Østergaard Andersen, Christian and Jarløv, Jens Otto and Schønheyder, Henrik Carl and Knudsen, Jenny Dahl}},
  issn         = {{1661-7827}},
  keywords     = {{Bacteraemia; Bloodstream infection; Epidemiology; Mortality; Population-based study}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{11}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Environmental Research and Public Health}},
  title        = {{Decrease in all-cause 30-day mortality after bacteraemia over a 15-year period : A population-based cohort study in Denmark in 2000–2014}},
  url          = {{http://dx.doi.org/10.3390/ijerph18115982}},
  doi          = {{10.3390/ijerph18115982}},
  volume       = {{18}},
  year         = {{2021}},
}