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Structural studies of cysteine proteases and their inhibitors

Grzonka, Zbigniew ; Jankowska, Elzbieta ; Kasprzykowski, Franciszek ; Kasprzykowska, Regina ; Lankiewicz, Leszek ; Wiczk, Wieslaw ; Wieczerzak, Ewa ; Ciarkowski, Jerzy ; Drabik, Piotr and Janowski, Robert , et al. (2001) In Acta Biochimica Polonica 48(1). p.1-20
Abstract
Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding fragments of cystatins.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
structure-activity relationship, synthetic inhibitors, cystatins, cysteine proteases
in
Acta Biochimica Polonica
volume
48
issue
1
pages
1 - 20
publisher
Panstwowe Wydawnictwo Naukowe
external identifiers
  • pmid:11440158
  • scopus:0035227644
ISSN
0001-527X
language
English
LU publication?
yes
id
c2f3df10-c752-4141-874c-959b2156c0d3 (old id 1121036)
date added to LUP
2016-04-01 15:18:05
date last changed
2023-01-04 08:39:18
@article{c2f3df10-c752-4141-874c-959b2156c0d3,
  abstract     = {{Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding fragments of cystatins.}},
  author       = {{Grzonka, Zbigniew and Jankowska, Elzbieta and Kasprzykowski, Franciszek and Kasprzykowska, Regina and Lankiewicz, Leszek and Wiczk, Wieslaw and Wieczerzak, Ewa and Ciarkowski, Jerzy and Drabik, Piotr and Janowski, Robert and Kozak, Maciej and Jaskolski, Mariusz and Grubb, Anders}},
  issn         = {{0001-527X}},
  keywords     = {{structure-activity relationship; synthetic inhibitors; cystatins; cysteine proteases}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{1--20}},
  publisher    = {{Panstwowe Wydawnictwo Naukowe}},
  series       = {{Acta Biochimica Polonica}},
  title        = {{Structural studies of cysteine proteases and their inhibitors}},
  volume       = {{48}},
  year         = {{2001}},
}