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Regional times to equilibria and their impact on semi-quantification of [18F]AV-1451 uptake

Heurling, Kerstin; Smith, Ruben LU ; Strandberg, Olof T. LU ; Schain, Martin; Ohlsson, Tomas; Hansson, Oskar LU and Schöll, Michael LU (2018) In Journal of Cerebral Blood Flow and Metabolism
Abstract

The semi-quantitative estimate standardised uptake value ratios (SUVR) correlate well with specific binding of the tracer expressed as distribution volume ratios (DVR) for the tau positron emission tomography tracer [18F]AV-1451 uptake and are therefore widely used as proxy for tracer binding. With regard to tracer kinetic modelling, there exists a time point when SUVR deviates minimally from DVR, occurring when the specific binding reaches a transient equilibrium. Here, we have investigated whether the time to equilibrium affects the agreement between SUVR and DVR across different brain regions. We show that the time required to reach equilibrium differs across brain regions, resulting in region-specific biases. However,... (More)

The semi-quantitative estimate standardised uptake value ratios (SUVR) correlate well with specific binding of the tracer expressed as distribution volume ratios (DVR) for the tau positron emission tomography tracer [18F]AV-1451 uptake and are therefore widely used as proxy for tracer binding. With regard to tracer kinetic modelling, there exists a time point when SUVR deviates minimally from DVR, occurring when the specific binding reaches a transient equilibrium. Here, we have investigated whether the time to equilibrium affects the agreement between SUVR and DVR across different brain regions. We show that the time required to reach equilibrium differs across brain regions, resulting in region-specific biases. However, even though the 80–100 min post-injection time window did not show the smallest bias numerically, the disagreement between SUVR and DVR varied least between regions during this time. In conclusion, our findings suggest a regional component to the bias of SUVR related to the time to transient equilibrium of the specific binding. [18F]AV-1451 uptake should consequently be interpreted with some caution when compared across brain regions using this method of quantification. The commonly used time window 80–100 min post-injection shows the most consistent bias across regions and is recommended for semi-quantification of [18F]AV-1451.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Alzheimer’s, biomarkers, neurodegeneration, pharmacokinetics, positron emission tomography
in
Journal of Cerebral Blood Flow and Metabolism
publisher
Nature Publishing Group
external identifiers
  • scopus:85052289003
ISSN
0271-678X
DOI
10.1177/0271678X18791430
language
English
LU publication?
yes
id
c31c519b-e5d8-4956-b708-b4b133131ed0
date added to LUP
2018-09-28 07:18:08
date last changed
2019-09-17 04:39:17
@article{c31c519b-e5d8-4956-b708-b4b133131ed0,
  abstract     = {<p>The semi-quantitative estimate standardised uptake value ratios (SUVR) correlate well with specific binding of the tracer expressed as distribution volume ratios (DVR) for the tau positron emission tomography tracer [<sup>18</sup>F]AV-1451 uptake and are therefore widely used as proxy for tracer binding. With regard to tracer kinetic modelling, there exists a time point when SUVR deviates minimally from DVR, occurring when the specific binding reaches a transient equilibrium. Here, we have investigated whether the time to equilibrium affects the agreement between SUVR and DVR across different brain regions. We show that the time required to reach equilibrium differs across brain regions, resulting in region-specific biases. However, even though the 80–100 min post-injection time window did not show the smallest bias numerically, the disagreement between SUVR and DVR varied least between regions during this time. In conclusion, our findings suggest a regional component to the bias of SUVR related to the time to transient equilibrium of the specific binding. [<sup>18</sup>F]AV-1451 uptake should consequently be interpreted with some caution when compared across brain regions using this method of quantification. The commonly used time window 80–100 min post-injection shows the most consistent bias across regions and is recommended for semi-quantification of [<sup>18</sup>F]AV-1451.</p>},
  author       = {Heurling, Kerstin and Smith, Ruben and Strandberg, Olof T. and Schain, Martin and Ohlsson, Tomas and Hansson, Oskar and Schöll, Michael},
  issn         = {0271-678X},
  keyword      = {Alzheimer’s,biomarkers,neurodegeneration,pharmacokinetics,positron emission tomography},
  language     = {eng},
  month        = {08},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Cerebral Blood Flow and Metabolism},
  title        = {Regional times to equilibria and their impact on semi-quantification of [<sup>18</sup>F]AV-1451 uptake},
  url          = {http://dx.doi.org/10.1177/0271678X18791430},
  year         = {2018},
}