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Recovery after total intravenous general anaesthesia or spinal anaesthesia for total knee arthroplasty: a randomized trial.

Harsten, Andreas LU ; Kehlet, H and Toksvig-Larsen, Sören LU (2013) In British Journal of Anaesthesia 111(3). p.391-399
Abstract
BACKGROUND: /st>This study was undertaken to compare the effects of general anaesthesia (GA) and spinal anaesthesia (SA) on the need for postoperative hospitalization and early postoperative comfort in patients undergoing fast-track total knee arthroplasty (TKA). METHODS: /st>One hundred and twenty subjects were randomly allocated to receive either intrathecal bupivacaine (SA group) or GA with target controlled infusion of propofol and remifentanil (GA group). Primary outcome was length of hospital stay (LOS) defined as time from end of surgery until the subject met the hospital discharge criteria. Secondary outcome parameters included actual time of discharge, postoperative pain, intraoperative blood loss, length of stay in the Post... (More)
BACKGROUND: /st>This study was undertaken to compare the effects of general anaesthesia (GA) and spinal anaesthesia (SA) on the need for postoperative hospitalization and early postoperative comfort in patients undergoing fast-track total knee arthroplasty (TKA). METHODS: /st>One hundred and twenty subjects were randomly allocated to receive either intrathecal bupivacaine (SA group) or GA with target controlled infusion of propofol and remifentanil (GA group). Primary outcome was length of hospital stay (LOS) defined as time from end of surgery until the subject met the hospital discharge criteria. Secondary outcome parameters included actual time of discharge, postoperative pain, intraoperative blood loss, length of stay in the Post Anaesthesia Care Unit, dizziness, postoperative nausea and vomiting, need for urinary catheterization and subject satisfaction. RESULTS: /st>GA resulted in shorter LOS (46 vs 52 h, P<0.001), and less nausea and vomiting (4 vs 15, P<0.05) and dizziness (VAS 0 mm vs 20 mm, P<0.05) compared with SA. During the first 2 postoperative hours, GA patients had higher pain scores (P<0.001), but after 6 h the SA group had significantly higher pain scores (P<0.001). Subjects in the GA group used fewer patient-controlled analgesia doses and less morphine (P<0.01), and were able to walk earlier compared with the SA group (P<0.001). Subjects receiving SA would request a change in the method of anaesthesia in the event of a subsequent operation more often than the GA subjects (P<0.05). CONCLUSION: /st>GA had more favourable recovery effects after TKA compared with SA. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Anaesthesia
volume
111
issue
3
pages
391 - 399
publisher
Elsevier
external identifiers
  • wos:000323346900012
  • pmid:23578860
  • scopus:84882750922
ISSN
1471-6771
DOI
10.1093/bja/aet104
language
English
LU publication?
yes
id
c34a1ed3-37f2-46cf-8b3a-8cbd55ac4be0 (old id 3733860)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23578860?dopt=Abstract
date added to LUP
2016-04-01 10:16:03
date last changed
2022-04-04 08:21:56
@article{c34a1ed3-37f2-46cf-8b3a-8cbd55ac4be0,
  abstract     = {{BACKGROUND: /st&gt;This study was undertaken to compare the effects of general anaesthesia (GA) and spinal anaesthesia (SA) on the need for postoperative hospitalization and early postoperative comfort in patients undergoing fast-track total knee arthroplasty (TKA). METHODS: /st&gt;One hundred and twenty subjects were randomly allocated to receive either intrathecal bupivacaine (SA group) or GA with target controlled infusion of propofol and remifentanil (GA group). Primary outcome was length of hospital stay (LOS) defined as time from end of surgery until the subject met the hospital discharge criteria. Secondary outcome parameters included actual time of discharge, postoperative pain, intraoperative blood loss, length of stay in the Post Anaesthesia Care Unit, dizziness, postoperative nausea and vomiting, need for urinary catheterization and subject satisfaction. RESULTS: /st&gt;GA resulted in shorter LOS (46 vs 52 h, P&lt;0.001), and less nausea and vomiting (4 vs 15, P&lt;0.05) and dizziness (VAS 0 mm vs 20 mm, P&lt;0.05) compared with SA. During the first 2 postoperative hours, GA patients had higher pain scores (P&lt;0.001), but after 6 h the SA group had significantly higher pain scores (P&lt;0.001). Subjects in the GA group used fewer patient-controlled analgesia doses and less morphine (P&lt;0.01), and were able to walk earlier compared with the SA group (P&lt;0.001). Subjects receiving SA would request a change in the method of anaesthesia in the event of a subsequent operation more often than the GA subjects (P&lt;0.05). CONCLUSION: /st&gt;GA had more favourable recovery effects after TKA compared with SA.}},
  author       = {{Harsten, Andreas and Kehlet, H and Toksvig-Larsen, Sören}},
  issn         = {{1471-6771}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{391--399}},
  publisher    = {{Elsevier}},
  series       = {{British Journal of Anaesthesia}},
  title        = {{Recovery after total intravenous general anaesthesia or spinal anaesthesia for total knee arthroplasty: a randomized trial.}},
  url          = {{https://lup.lub.lu.se/search/files/1698845/4053925.pdf}},
  doi          = {{10.1093/bja/aet104}},
  volume       = {{111}},
  year         = {{2013}},
}