Biomarkers of cellular aging during a controlled human malaria infection
(2021) In Scientific Reports 11.- Abstract
Cellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high interference of aging-related processes with host and environmental factors. To address this challenge, we took advantage of the controlled human malaria infection (CHMI) model. This approach allowed us to characterize the relationship among cellular aging markers prior, during and post malaria pathophysiology in humans, controlling for infection dose, individual heterogeneity, previous exposure and co-infections. We demonstrate that already low levels of Plasmodium falciparum impact cellular aging by inducing high levels of inflammation and redox-imbalance; and that cellular... (More)
Cellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high interference of aging-related processes with host and environmental factors. To address this challenge, we took advantage of the controlled human malaria infection (CHMI) model. This approach allowed us to characterize the relationship among cellular aging markers prior, during and post malaria pathophysiology in humans, controlling for infection dose, individual heterogeneity, previous exposure and co-infections. We demonstrate that already low levels of Plasmodium falciparum impact cellular aging by inducing high levels of inflammation and redox-imbalance; and that cellular senescence reversed after treatment and parasite clearance. This study provides insights into the complex relationship of telomere length, cellular senescence, telomerase expression and aging-related processes during a single malaria infection.
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- author
- Miglar, Aurelie ; Reuling, Isaie J ; Yap, Xi Zen ; Färnert, Anna ; Sauerwein, Robert W and Asghar, Muhammad LU
- publishing date
- 2021-09-21
- type
- Contribution to journal
- publication status
- published
- keywords
- Biomarkers/metabolism, Cellular Senescence, Humans, Malaria, Falciparum/pathology, Models, Biological
- in
- Scientific Reports
- volume
- 11
- article number
- 18733
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85115392668
- pmid:34548530
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-021-97985-y
- language
- English
- LU publication?
- no
- additional info
- © 2021. The Author(s).
- id
- c366f859-c0f9-4c85-89a1-be66da1dfb8c
- date added to LUP
- 2022-12-06 16:14:48
- date last changed
- 2024-04-04 13:50:27
@article{c366f859-c0f9-4c85-89a1-be66da1dfb8c,
abstract = {{<p>Cellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high interference of aging-related processes with host and environmental factors. To address this challenge, we took advantage of the controlled human malaria infection (CHMI) model. This approach allowed us to characterize the relationship among cellular aging markers prior, during and post malaria pathophysiology in humans, controlling for infection dose, individual heterogeneity, previous exposure and co-infections. We demonstrate that already low levels of Plasmodium falciparum impact cellular aging by inducing high levels of inflammation and redox-imbalance; and that cellular senescence reversed after treatment and parasite clearance. This study provides insights into the complex relationship of telomere length, cellular senescence, telomerase expression and aging-related processes during a single malaria infection.</p>}},
author = {{Miglar, Aurelie and Reuling, Isaie J and Yap, Xi Zen and Färnert, Anna and Sauerwein, Robert W and Asghar, Muhammad}},
issn = {{2045-2322}},
keywords = {{Biomarkers/metabolism; Cellular Senescence; Humans; Malaria, Falciparum/pathology; Models, Biological}},
language = {{eng}},
month = {{09}},
publisher = {{Nature Publishing Group}},
series = {{Scientific Reports}},
title = {{Biomarkers of cellular aging during a controlled human malaria infection}},
url = {{http://dx.doi.org/10.1038/s41598-021-97985-y}},
doi = {{10.1038/s41598-021-97985-y}},
volume = {{11}},
year = {{2021}},
}