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A preliminary choroid plexus volumetric study in individuals with psychosis

Senay, Olcay ; Seethaler, Magdalena ; Makris, Nikos ; Yeterian, Edward ; Rushmore, Jarrett ; Cho, Kang Ik K ; Rizzoni, Elizabeth ; Heller, Carina ; Pasternak, Ofer and Szczepankiewicz, Filip LU orcid , et al. (2023) In Human Brain Mapping 44(6). p.2465-2478
Abstract

The choroid plexus (ChP) is part of the blood-cerebrospinal fluid barrier, regulating brain homeostasis and the brain's response to peripheral events. Its upregulation and enlargement are considered essential in psychosis. However, the timing of the ChP enlargement has not been established. This study introduces a novel magnetic resonance imaging-based segmentation method to examine ChP volumes in two cohorts of individuals with psychosis. The first sample consists of 41 individuals with early course psychosis (mean duration of illness = 1.78 years) and 30 healthy individuals. The second sample consists of 30 individuals with chronic psychosis (mean duration of illness = 7.96 years) and 34 healthy individuals. We utilized manual... (More)

The choroid plexus (ChP) is part of the blood-cerebrospinal fluid barrier, regulating brain homeostasis and the brain's response to peripheral events. Its upregulation and enlargement are considered essential in psychosis. However, the timing of the ChP enlargement has not been established. This study introduces a novel magnetic resonance imaging-based segmentation method to examine ChP volumes in two cohorts of individuals with psychosis. The first sample consists of 41 individuals with early course psychosis (mean duration of illness = 1.78 years) and 30 healthy individuals. The second sample consists of 30 individuals with chronic psychosis (mean duration of illness = 7.96 years) and 34 healthy individuals. We utilized manual segmentation to measure ChP volumes. We applied ANCOVAs to compare normalized ChP volumes between groups and partial correlations to investigate the relationship between ChP, LV volumes, and clinical characteristics. Our segmentation demonstrated good reliability (.87). We further showed a significant ChP volume increase in early psychosis (left: p < .00010, right: p < .00010) and a significant positive correlation between higher ChP and higher LV volumes in chronic psychosis (left: r = .54, p = .0030, right: r = .68; p < .0010). Our study suggests that ChP enlargement may be a marker of acute response around disease onset. It might also play a modulatory role in the chronic enlargement of lateral ventricles, often reported in psychosis. Future longitudinal studies should investigate the dynamics of ChP enlargement as a promising marker for novel therapeutic strategies.

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publishing date
type
Contribution to journal
publication status
published
keywords
Humans, Choroid Plexus/diagnostic imaging, Reproducibility of Results, Psychotic Disorders/diagnostic imaging, Magnetic Resonance Imaging, Brain/pathology
in
Human Brain Mapping
volume
44
issue
6
pages
2465 - 2478
publisher
Wiley-Liss Inc.
external identifiers
  • pmid:36744628
  • scopus:85147521321
ISSN
1065-9471
DOI
10.1002/hbm.26224
language
English
LU publication?
no
additional info
© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
id
c37592d2-8e76-42c1-a6f4-bbedbc223351
date added to LUP
2023-06-01 14:02:16
date last changed
2025-06-17 01:10:24
@article{c37592d2-8e76-42c1-a6f4-bbedbc223351,
  abstract     = {{<p>The choroid plexus (ChP) is part of the blood-cerebrospinal fluid barrier, regulating brain homeostasis and the brain's response to peripheral events. Its upregulation and enlargement are considered essential in psychosis. However, the timing of the ChP enlargement has not been established. This study introduces a novel magnetic resonance imaging-based segmentation method to examine ChP volumes in two cohorts of individuals with psychosis. The first sample consists of 41 individuals with early course psychosis (mean duration of illness = 1.78 years) and 30 healthy individuals. The second sample consists of 30 individuals with chronic psychosis (mean duration of illness = 7.96 years) and 34 healthy individuals. We utilized manual segmentation to measure ChP volumes. We applied ANCOVAs to compare normalized ChP volumes between groups and partial correlations to investigate the relationship between ChP, LV volumes, and clinical characteristics. Our segmentation demonstrated good reliability (.87). We further showed a significant ChP volume increase in early psychosis (left: p &lt; .00010, right: p &lt; .00010) and a significant positive correlation between higher ChP and higher LV volumes in chronic psychosis (left: r = .54, p = .0030, right: r = .68; p &lt; .0010). Our study suggests that ChP enlargement may be a marker of acute response around disease onset. It might also play a modulatory role in the chronic enlargement of lateral ventricles, often reported in psychosis. Future longitudinal studies should investigate the dynamics of ChP enlargement as a promising marker for novel therapeutic strategies.</p>}},
  author       = {{Senay, Olcay and Seethaler, Magdalena and Makris, Nikos and Yeterian, Edward and Rushmore, Jarrett and Cho, Kang Ik K and Rizzoni, Elizabeth and Heller, Carina and Pasternak, Ofer and Szczepankiewicz, Filip and Westin, Carl-Frederik and Losak, Jan and Ustohal, Libor and Tomandl, Josef and Vojtisek, Lubomir and Kudlicka, Peter and Kikinis, Zora and Holt, Daphne and Lewandowski, Kathryn E and Lizano, Paulo and Keshavan, Matcheri S and Öngür, Dost and Kasparek, Tomas and Breier, Alan and Shenton, Martha E and Seitz-Holland, Johanna and Kubicki, Marek}},
  issn         = {{1065-9471}},
  keywords     = {{Humans; Choroid Plexus/diagnostic imaging; Reproducibility of Results; Psychotic Disorders/diagnostic imaging; Magnetic Resonance Imaging; Brain/pathology}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{2465--2478}},
  publisher    = {{Wiley-Liss Inc.}},
  series       = {{Human Brain Mapping}},
  title        = {{A preliminary choroid plexus volumetric study in individuals with psychosis}},
  url          = {{http://dx.doi.org/10.1002/hbm.26224}},
  doi          = {{10.1002/hbm.26224}},
  volume       = {{44}},
  year         = {{2023}},
}