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A national study of health-related quality of life in patients with cancer of the base of the tongue compared to the general population and to patients with tonsillar carcinoma

Berg, Malin ; Adnan, Ali ; Högmo, Anders ; Sjödin, Helena ; Gebre-Medhin, Maria LU ; Laurell, Göran ; Reizenstein, Johan ; Farnebo, Lovisa ; Norberg, Lena Spaak and Notstam, Isak , et al. (2021) In Head and Neck 43(12). p.3843-3856
Abstract

Background: This exploratory, registry-based, cross-sectional study aimed to evaluate patients' health-related quality of life (HRQOL) in a subsite of oropharyngeal cancer: cancer of the base of the tongue (CBT). Methods: CBT patients, treated with curative intent, completed the EORTC QLQ-C30 and QLQ-H&N35 questionnaires 15 months after diagnosis. The HRQOL of CBT patients was compared to reference scores from the general population and to that of tonsillar carcinoma patients. Results: The 190 CBT patients scored significantly worse than members of the general population on most scales. CBT patients with human papilloma virus (HPV)-positive tumors had significantly better HRQOL on 8 of 28 scales than HPV-negative patients. Compared... (More)

Background: This exploratory, registry-based, cross-sectional study aimed to evaluate patients' health-related quality of life (HRQOL) in a subsite of oropharyngeal cancer: cancer of the base of the tongue (CBT). Methods: CBT patients, treated with curative intent, completed the EORTC QLQ-C30 and QLQ-H&N35 questionnaires 15 months after diagnosis. The HRQOL of CBT patients was compared to reference scores from the general population and to that of tonsillar carcinoma patients. Results: The 190 CBT patients scored significantly worse than members of the general population on most scales. CBT patients with human papilloma virus (HPV)-positive tumors had significantly better HRQOL on 8 of 28 scales than HPV-negative patients. Compared to 405 tonsillar carcinoma patients, CBT patients had significantly worse HRQOL on 8 of the 28 scales, the majority local head and neck related problems. Conclusion: One year after treatment, CBT patients' HRQOL was significantly worse in many areas compared to that of the general population and slightly worse than that of tonsillar carcinoma patients.

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type
Contribution to journal
publication status
published
subject
keywords
cancer of the base of the tongue, head-and-neck cancer, human papillomavirus, oropharyngeal cancer, quality-of-life
in
Head and Neck
volume
43
issue
12
pages
3843 - 3856
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85115841892
  • pmid:34558771
ISSN
1043-3074
DOI
10.1002/hed.26882
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 Wiley Periodicals LLC.
id
c399ef35-136d-461c-91bf-e183c6c1dcf4
date added to LUP
2021-10-20 10:33:35
date last changed
2024-06-15 18:29:05
@article{c399ef35-136d-461c-91bf-e183c6c1dcf4,
  abstract     = {{<p>Background: This exploratory, registry-based, cross-sectional study aimed to evaluate patients' health-related quality of life (HRQOL) in a subsite of oropharyngeal cancer: cancer of the base of the tongue (CBT). Methods: CBT patients, treated with curative intent, completed the EORTC QLQ-C30 and QLQ-H&amp;N35 questionnaires 15 months after diagnosis. The HRQOL of CBT patients was compared to reference scores from the general population and to that of tonsillar carcinoma patients. Results: The 190 CBT patients scored significantly worse than members of the general population on most scales. CBT patients with human papilloma virus (HPV)-positive tumors had significantly better HRQOL on 8 of 28 scales than HPV-negative patients. Compared to 405 tonsillar carcinoma patients, CBT patients had significantly worse HRQOL on 8 of the 28 scales, the majority local head and neck related problems. Conclusion: One year after treatment, CBT patients' HRQOL was significantly worse in many areas compared to that of the general population and slightly worse than that of tonsillar carcinoma patients.</p>}},
  author       = {{Berg, Malin and Adnan, Ali and Högmo, Anders and Sjödin, Helena and Gebre-Medhin, Maria and Laurell, Göran and Reizenstein, Johan and Farnebo, Lovisa and Norberg, Lena Spaak and Notstam, Isak and Holmberg, Erik and Cange, Hedda Haugen and Hammerlid, Eva}},
  issn         = {{1043-3074}},
  keywords     = {{cancer of the base of the tongue; head-and-neck cancer; human papillomavirus; oropharyngeal cancer; quality-of-life}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{3843--3856}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Head and Neck}},
  title        = {{A national study of health-related quality of life in patients with cancer of the base of the tongue compared to the general population and to patients with tonsillar carcinoma}},
  url          = {{http://dx.doi.org/10.1002/hed.26882}},
  doi          = {{10.1002/hed.26882}},
  volume       = {{43}},
  year         = {{2021}},
}